A non-linear connection between the total cholesterol to high-density lipoprotein cholesterol ratio and stroke risk: a retrospective cohort study from the China Health and Retirement Longitudinal Study

Table 5 The result of the two-piecewise Cox proportional hazards regression model

Incident stroke	HR (95%CI)	P
Fitting model by standard linear regression (per 1 increase in TC/HDL-C ratio)	1.05 (1.00, 1.10)	0.0410
Fitting model by two-piecewise Cox proportional hazards
The inflection point of the TC/HDL-C ratio	3.71
≤ 3.71 (per 1 increase in TC/HDL-C ratio)	1.25 (1.07, 1.45)	0.0039
> 3.71 (per 1 increase in TC/HDL-C ratio)	1.00 (0.94, 1.06)	0.9232
P for the log-likelihood ratio test	0.016

We adjusted for age, gender, educational attainment, annual income, smoking status, drinking status, physical activity, BMI, CLD, liver disease, CRP, WBC, Scr, Cystatin C, hemoglobin, FPG, HbA1c, lipid-lowering medication, antihypertensive medication, and glucose-lowering medication
HR hazard ratios, CI confidence, TC/HDL-C ratio total cholesterol to high-density lipoprotein cholesterol ratio

ISSN: 2047-783X