Table 6 Effect size of TC/HDL-C ratio on stroke in prespecified and exploratory subgroups
Characteristic | No of participants | HR (95%CI) P value | P for interaction |
|---|---|---|---|
Age (years) | 0.5714 | ||
 < 60 | 5676 | 1.06 (1.00, 1.13) 0.0553 |  |
 ≥ 60 | 4508 | 1.04 (0.98, 1.10) 0.2399 |  |
Gender | 0.6418 | ||
 Male | 4754 | 1.07 (1.00, 1.14) 0.0507 |  |
 Female | 5430 | 1.05 (0.98, 1.11) 0.1442 |  |
BMI (kg/m2) | 0.2616 | ||
 < 25 | 6921 | 1.08 (1.02, 1.15) 0.0086 |  |
 ≥ 25 | 3263 | 1.03 (0.97, 1.10) 0.3598 |  |
Liver disease | 0.1123 | ||
 No | 9767 | 1.05 (1.00, 1.10) 0.0515 |  |
 Yes | 417 | 1.20 (1.02, 1.41) 0.0235 |  |
CLD | 0.2862 | ||
 No | 9125 | 0.98 (0.87, 1.12) 0.8169 |  |
 Yes | 1059 | 1.06 (1.01, 1.11) 0.0171 |  |
Smoking status | 0.1261 | ||
 Never smokers | 6270 | 1.07 (1.01, 1.13) 0.0215 |  |
 Ever smokers | 861 | 1.18 (1.03, 1.35) 0.0138 |  |
 Current smokers | 3053 | 0.97 (0.89, 1.06) 0.5454 |  |
Drinking status | 0.2178 | ||
 Never drinkers | 1385 | 1.05 (0.94, 1.18) 0.3885 |  |
 Ever drinkers | 6226 | 1.10 (1.04, 1.16) 0.0016 |  |
 Current drinkers | 2573 | 0.97 (0.88, 1.07) 0.5691 |  |
Physical activity | 0.2456 | ||
 No | 3665 | 1.08 (1.02, 1.15) 0.0124 |  |
 Yes | 6519 | 1.03 (0.97, 1.10) 0.3322 |  |