O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems

Table 1 List of commonly used and emerging metabolic, pharmacological, and genetic interventions for studying the functional role of HBP/O-GlcNAcylation in biological systems

Group	Targets	Metabolites/inhibitors/genetic techniques	Effect of O-GlcNAcylation	References
Metabolic interventions	HBP	Glucose	Increase	[7, 8]
		Glutamine	Increase	[9, 10]
		Glucosamine	Increase	[22, 23]
		N-acetylglucosamine	Increase	[15, 16]
Pharmacological interventions	GFAT	DON	Decrease	[24, 25]
	GFAT	Azaserine	Decrease	[9, 26]
	OGT	Alloxan	Decrease	[21, 27]
		Ac₄-5SGlcNAc	Decrease	[28, 29]
		ST045849	Decrease	[30, 31]
		OSMI-1, − 2, − 3, and − 4	Decrease	[32, 33]
	OGA	STZ	Increase	[34, 35]
		PUGNAc	Increase	[36, 37]
		NButGT	Increase	[38, 39]
		GlcNAcstatin	Increase	[40, 41]
		NAG-thiazoline	Increase	[42, 43]
		thiamet G	Increase	[44, 45]
Genetic interventions	OGT	siRNA	Decrease	[46, 47]
		Adenoviral overexpression	Increase	[46, 47]
		Transgenic mouse models	Increase	[48]
	OGA	siRNA	Increase	[49, 50]
		Adenoviral overexpression	Decrease	[47, 51]
		Transgenic mouse models	Decrease	[48]

ISSN: 2047-783X