Table 3 List of models for neuronal stress tolerance modulated by O-GlcNAc modification

In vitro

OGD/R

Primary neuron cultures, Primary astrocyte cultures, HT22 cells

Increase

Increase

P, G

[123,124,125,126]

LPS

BV2 microglia cells

Increase

Increase

M, P

[44, 127]

Aβ

Primary cortical neurons

, CHO cells

Decrease

Increase

P

[128]

Glutamate

PC12 cells

Increase

Increase

P, G

[129]

In vivo

Transient global ischaemia, tMCAO, pMCAO

Mice, Rat

Young: increase

Aged: no change

Increase

M, P, G

[44, 45, 127, 130,131,132,133,134,135]

CA/CPR

Mice

Young: increase

Aged: no change

Increase

M, P

[45, 136]

Hypoxia

Mice

N/A

Increase

P

[137]

RH

Zebrafish

Decrease

Increase

M

[138]

SAH

Mice

N/A

Increase

P

[126]