Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit

Table 2 Animal studies revealing the potential role of GABA and effects of GABA modulators on the motor and non-motor symptoms of PD

A study type	Findings	Refs.
Rats	Dysregulation of GABAergic neurons in the SNpc leads to abnormal neuronal firing in rat PD models	[65]
Rats	GABA agonists protect dopaminergic neurons and striatal terminals from oxidative stress in 6-OHDA-induced PD in	[56]
Rats	Most antiepileptic drugs increase PD risk	[130]

ISSN: 2047-783X