Replication study identified EFEMP1 association with varicose vein predisposition among Indians

Table 1 Replication of GWAS variants in Indians

Chr	SNP	Gene	Chromosome location (GRCh37)	OR	L95	U95	p-value
1	rs2820464	LYPLAL1-AS1	1:219,693,220	1.19	0.85	1.66	0.31
2	rs3791679*	EFEMP1	2:56,096,892	1.43	1.04	1.97	0.02
3	rs2713575	LINC01565 / GATA2	3:128,294,355	0.92	0.68	1.25	0.59
4	rs11728719	SORBS2	4:186,696,172	1.10	0.72	1.68	0.65
6	rs1936800	LOC105377989 / RSPO3	6:127,436,064	0.98	0.72	1.32	0.88
8	rs10504825	CPNE3	8:87,567,848	0.85	0.62	1.18	0.34
10	rs61863928	-	10:64,449,549	0.98	0.72	1.34	0.88
16	rs11076178	CPNE2	16:57,146,402	0.89	0.61	1.31	0.56

Chr chromosome, SNP single nucleotide polymorphism, OR odds ratio, L95 and U95 95% lower and upper confidence interval
rs3791679* of EFEMP1 gene showed association

ISSN: 2047-783X