Table 4 Adjusted hazard ratios of prenatal antibiotics for childhood atopic diseases by Cox regression models*
Asthma | Allergic rhinitis | Atopic dermatitis | ||||
|---|---|---|---|---|---|---|
HR | 95%CI | HR | 95%CI | HR | 95%CI | |
Stratified by timing of prescribing antibiotics | ||||||
1st trimester | 1.07 | 1.06 ~ 1.08 | 1.09 | 1.08 ~ 1.09 | 1.13 | 1.12 ~ 1.14 |
2nd trimester | 1.06 | 1.03 ~ 1.08 | 1.06 | 1.05 ~ 1.08 | 1.07 | 1.04 ~ 1.09 |
3rd trimester | 1.02 | 0.99 ~ 1.04 | 1.04 | 1.02 ~ 1.06 | 1.06 | 1.04 ~ 1.09 |
Stratified by cumulative times of antibiotics prescription | ||||||
1 time | 1.04 | 1.04 ~ 1.05 | 1.06 | 1.06 ~ 1.07 | 1.08 | 1.07 ~ 1.09 |
2 times | 1.06 | 1.05 ~ 1.08 | 1.09 | 1.08 ~ 1.10 | 1.13 | 1.11 ~ 1.14 |
≥ 3 times | 1.11 | 1.09 ~ 1.12 | 1.12 | 1.11 ~ 1.13 | 1.20 | 1.19 ~ 1.22 |