Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy

Zhang, Qiqi; Zhang, Junkui; Lan, Tianyi; He, Jiayue; Lei, Bin; Wang, Hongnan; Mei, Zhiqiang; Lv, Chaoxiang

doi:10.1186/s40001-024-01795-7

Table 2 PIAS family gene expression was related to the prognosis of different cancers in PrognoScan

From: Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy

Gene	Dataset	Cancer type	Endpoint	Number	COX p-value	HR [95% CI^low—CI^upp]
PIAS1	GSE2034	Breast cancer	DFS	286	0.0042	0.41 [0.22–0.75]
PIAS1	GSE2837	Head and neck cancer	RFS	28	0.0059	0.35 [0.16–0.74]
PIAS1	GSE31210	Lung cancer	RFS	204	0.0067	0.22 [0.07–0.66]
PIAS1	GSE17537	Colorectal cancer	DFS	55	0.0120	5.71 [1.46–22.37]
PIAS1	GSE7378	Breast cancer	DFS	54	0.0430	0.11 [0.01–0.93]
PIAS2	GSE12276	Breast cancer	RFS	204	0.000044	2.41 [1.58–3.68]
PIAS2	GSE12276	Breast cancer	RFS	204	0.0012	1.83 [1.27–2.63]
PIAS2	GSE17710	Lung cancer	RFS	56	0.0032	2.11 [1.28–3.46]
PIAS2	GSE13507	Bladder cancer	OS	165	0.0052	0.37 [0.18–0.74]
PIAS2	GSE17537	Colorectal cancer	DFS	55	0.0067	0.02 [0.00–0.32]
PIAS2	GSE17710	Lung cancer	OS	56	0.0086	1.93 [1.18–3.16]
PIAS2	GSE17710	Lung cancer	RFS	56	0.0104	1.92 [1.17–3.16]
PIAS2	GSE13507	Bladder cancer	DSS	165	0.0106	0.26 [0.09–0.73]
PIAS2	GSE12276	Breast cancer	RFS	204	0.0111	1.54 [1.10–2.14]
PIAS2	GSE31210	Lung cancer	RFS	204	0.0143	3.10 [1.25–7.67]
PIAS2	GSE16581	Brain cancer	OS	67	0.0171	0.03 [0.00–0.55]
PIAS2	GSE17710	Lung cancer	OS	56	0.0224	1.74 [1.08–2.79]
PIAS2	GSE17537	Colorectal cancer	DSS	49	0.0261	0.01 [0.00–0.61]
PIAS2	GSE19234	Skin cancer	OS	38	0.0369	2.67 [1.06–6.73]
PIAS2	GSE31210	Lung cancer	OS	204	0.0387	3.91 [1.07–14.24]
PIAS3	GSE14333	Colorectal cancer	DFS	226	0.0017	2.40 [1.39–4.16]
PIAS3	GSE17536	Colorectal cancer	DSS	177	0.0080	2.19 [1.23–3.91]
PIAS3	GSE17536	Colorectal cancer	OS	177	0.0296	1.79 [1.06–3.01]
PIAS4	GSE7378	Breast cancer	DFS	54	0.0206	6.39 [1.33–30.71]
PIAS4	GSE9195	Breast cancer	RFS	77	0.0317	3.05 [1.10–8.42]
PIAS4	GSE13213	Lung cancer	OS	117	0.0354	1.85 [1.04–3.27]
PIAS4	GSE9195	Breast cancer	DFS	77	0.0417	3.28 [1.05–10.32]
PIAS4	GSE7696	Brain cancer	OS	70	0.0449	3.25 [1.03–10.26]

Annotation: OS overall survival, DFS Disease Free Survival), DSS disease specific survival, RFS relapse free survival, HR (hazard ratio), CI Confidence Interval

Back to article page

ISSN: 2047-783X

Contact us

Submission enquiries: jacinth.kennady@springernature.com
General enquiries: info@biomedcentral.com

European Journal of Medical Research

Contact us