Fig. 2

a Infiltrative growth of submucosal tumour cells; b ‘‘pro-epithelial phenomenon’’ of tumour cells; c marked increase in lymphocytes within the largely normal intestinal mucosa; d hyperplasia of endothelial veins in tumour tissues; e tumour cells are more consistent in morphology, small-medium in size; f tumour cells are medium in size with heterogeneity, nuclear fission and fragmentation are seen; g tumour cell CD3 cytoplasmic and cytosolic positivity; h tumour cell CD8 cytosolic and cytosolic positivity; i tumour cell CD56 cytosolic positivity; j tumour cell TIA-1 cytoplasmic positivity; k tumour cell CD103 cytosolic positivity; l Tumour cell H3K36me3 cytosolic positivity; m tumour cell Ki-67 proliferation index ranged from 50% to 80%; n tumour cell EBER negativity