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Fig. 3 | European Journal of Medical Research

Fig. 3

From: Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects

Fig. 3

Cross-sections from the uvula muscle showing different regions in a healthy subject (columns 1 and 2) and an OSA patient (column 3) immunostained for desmin (DES, green, A–C) and a riboprobe against desmin mRNA (red, D–F). Merged staining for DES and desmin mRNA are shown in panels G–I. Muscle fibers displaying either low or high mRNA expression in DES positive fibers (DES pos) are marked 1 and 2, respectively. Fibers lacking desmin (DES neg) and its mRNA are marked 3. Bar graph (J) shows the percentage of DES neg fibers with absence or very low mRNA expression in healthy subjects and patients (p=0.05). Note the intra-myofibrillar maldistribution and accumulations of mRNA (arrows) as well as the higher number of fibers lacking expression for DES and its mRNA in OSA patients. Scale bar=50μm

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European Journal of Medical Research

ISSN: 2047-783X

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