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Fig. 10 | European Journal of Medical Research

Fig. 10

From: Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing

Fig. 10

AP3S1 regulates EMT in ovarian cancer through the TGF-β pathway. A Significant inhibition of TGF-β and EMT pathways in ovarian cancer cells after AP3S1 knockdown. B The TGF-β pathway activator SRI-011381 rescues the decreased expression of TGF-β pathway and EMT-related proteins caused by AP3S1 knockdown. C Pirfenidone further exacerbates the decreased expression of TGF-β pathway and EMT-related proteins caused by AP3S1 knockdown. All data are mean ± SD. Significance calculated using the unpaired t-test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Representative data are from three independent experiments

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European Journal of Medical Research

ISSN: 2047-783X

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