Fig. 1

Clinical characteristics of ion channel subtypes in colorectal cancer. A The expression of 279 ion channel genes depicted in the TCGA CRC cohorts. The cluster and common clinical variables were used as patient annotations. B Four distinct subtypes were identified by principal component analysis of ion channel genes in the TCGA CRC dataset. C The proportion of samples (MSS, MSI-L, MSI-H) with microsatellite instability was shown in each subtype. D Kaplan–Meier curve among the four subtypes showed significant differences (log-rank test, p = 0.00013). TCGA The Cancer Genome Atlas, CRC colorectal cancer, MSS microsatellite stable, MSI-L microsatellite instability of lower degree, MSI-H microsatellite instability of higher degree