Table 4 Univariate and multivariate Cox analysis (Overall Survival) of prognostic covariates in patients with PC
Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
T stage (T3 & T4 vs. T1 & T2) | 176 | 2.053 (1.089–3.871) | 0.026 | 2.643 (0.296–23.597) | 0.384 |
N stage (N1 vs. N0) | 173 | 2.114 (1.259–3.549) | 0.005 | 1.768 (0.428–7.302) | 0.431 |
M stage (M1 vs. M0) | 84 | 1.050 (0.251–4.388) | 0.947 | 1.133 (0.123–10.469) | 0.912 |
Pathologic stage (Stage II & Stage III & Stage IV vs. Stage I) | 175 | 2.326 (1.067–5.069) | 0.034 | 0.202 (0.011–3.789) | 0.285 |
Radiation therapy (Yes vs. No) | 163 | 0.501 (0.294–0.854) | 0.011 | 0.210 (0.069–0.639) | 0.006 |
Primary therapy outcome (CR & PR vs. PD & SD) | 140 | 0.425 (0.267–0.675) |  < 0.001 | 0.458 (0.201–1.044) | 0.063 |
Age (> 65 vs. ≤ 65) | 178 | 1.306 (0.867–1.968) | 0.202 | 1.382 (0.625–3.054) | 0.424 |
Race (White vs. Asian & Black or African American) | 174 | 1.176 (0.589–2.345) | 0.646 | 6.404 (0.769–53.321) | 0.086 |
Gender (Male vs. Female) | 178 | 1.214 (0.808–1.825) | 0.350 | 0.872 (0.386–1.967) | 0.741 |
Histologic grade (G3 & G4 vs. G1 & G2) | 176 | 1.517 (0.983–2.340) | 0.060 | 2.220 (1.016–4.852) | 0.046 |
Residual tumor (R1 & R2 vs. R0) | 164 | 1.630 (1.051–2.528) | 0.029 | 1.107 (0.504–2.436) | 0.800 |
Anatomic neoplasm subdivision (Other vs. Head of Pancreas) | 178 | 0.427 (0.236–0.770) | 0.005 | 1.352 (0.367–4.978) | 0.650 |
FNDC3B (High vs. Low) | 178 | 1.880 (1.235–2.862) | 0.003 | 2.223 (0.910–5.430) | 0.079 |