Without stratification with age and sex | |||||
---|---|---|---|---|---|
NLRP3 | 1 NLRP3 dual effect for cancer | 2 Colchicine modulate NLRP3 effect for cancer | 3 Hyperlipidemia Hypertension Diabetes Liver cirrhosis | 4 Detection Bias Modulate aHRb,c | aHRa |
Effect of 1 + 2 + 3 + 4 = | |||||
Colorectal cancer—IMIDs colitis (− attenuating tumorigenic activity late stage of colitis + enhancing tumorigenic activity in early stage of colitis) | ± | −− | + | 0/+ | – |
Stratification with age and sex | |||||
---|---|---|---|---|---|
1 NLRP3 effect for cancer | 2 Testosterone (+) Estrogen (?) Effect For cancer | 3 Hyperlipidemia Hypertension Diabetes Tobacco use | 4 Colchicine Modulate NLRP3 Effect for cancer | aHRa Effect of 1 + 2 + 3 + 4 = | |
Colorectal cancerc | |||||
Male | + | + | + | −− | – |
Female | + | ? | + | −− | – |
> 65-year | + | 0 | + | 0/− | 0 |
< 65-year | + | + | + | −− | – |