Table 2 Summary of findings table with GRADE assessment quality of evidence
Outcomes | No. of participants (studies) | Relative effect (95% CI) | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of the evidence (GRADE) |
|---|---|---|---|---|---|---|---|---|
POD | 4304 (20 RCTs) | RR: 0.55; 95% CI 0.47 to 0.64 | Not serious | Not serious | Not serious | Serious | Not serious | Moderate |
POCD | 690 (7 RCTs) | RR: 0.74; 95% CI 0.6 to 0.91 | Not serious | Serious | Not serious | Serious | Not serious | Low |
Hypertension | 694 (4 RCTs) | RR: 1.35; 95% CI 0.81 to 2.24 | Not serious | Not serious | Not serious | Serious | Not serious | Moderate |
Hypotension | 994 (7 RCTs) | RR: 1.42; 95% CI 1.08 to 1.86 | Not serious | Not serious | Not serious | Serious | Not serious | Moderate |
Bradycardia | 994 (7 RCTs) | RR: 1.66; 95% CI1.23 to 2.26 | Not serious | Not serious | Not serious | Serious | Not serious | Moderate |