Diffuse postoperative peritonitis -value of diagnostic parameters and impact of early indication for relaparotomy
© I. Holzapfel Publishers 2009
Received: 2 May 2009
Accepted: 9 June 2009
Published: 3 November 2009
Current criteria for performing relaparotomy for suspected peritonitis are non explicit and based on non-quantitative, subjective arguments or hospital practice. The aim of this study was to determine the value of routinely used clinical and diagnostic parameters in early detection of postoperative, diffuse peritonitis (PP). Furthermore, the prognosis and outcome after early indication for relaparotomy in patients with PP compared to community-aquired peritonitis (CAP) was evaluated.
Between 1999 and 2008, a total of 251 patients with diffuse secondary peritonitis either postoperative (PP) or community acquired (CAP) were analyzed retrospectively. PP (n = 114) and CAP (n = 137) were compared regarding physical examination, MPI-Score, APACHE II-Score, evidence of organ failure, laboratory parameters, diagnostic instruments and clinical course. The treatment regimen comprised surgical source control (with/without programmed lavage), abdominal closure and relaparotomy on demand, broad spectrum antibiotic therapy and intensive care support.
The APACHE II-Score (20 CAP vs. 22 PP, p = 0.012), MPI-Score (27 CAP vs. 30 PP, p = 0.001) and the number of lavages differed significantly. Positive phyiscal testing and signs of sepsis [abdominal pain (81.6% PP vs. CAP 97.1%, p = 0.03), rebound tenderness (21.9% vs. 35.8%, p = 0.02), fever (35.1% vs. 51.8%, p = 0.03)] occurred significantly less often in the PP patients than in the CAP group. Conventional radiography (66.2%) and ultrasonography (44.3%) had a lower diagnostic sensitivity than did abdominal CT-scan (97.2%). Mortality was higher in the PP group but did not differ significantly between the two groups (47.4% PP vs. 35.8% CAP, p = 0.06).
The value of physical tests and laboratory parameters in diagnosing abdominal sepsis is limited. CT-scanning revealed the highest diagnostic accuracy. A treatment regimen of early relaprotomy appears to be the most reasonable strategy for as early discovery of postoperative peritonitis as possible.
Secondary peritonitis accounts for approximately 90% of all peritonitis cases in western countries . Within this group diffuse postoperative peritonitis (PP) and abdominal sepsis are common concerns following surgical interventions. The current literature indicates a rate of between 30 and 42% for diffuse postoperative peritonitis within the subgroup of secondary peritonitis [2–4]. Despite the development of antibiotics and significant improvement in intensive care support, morbidity is high and mortality rates remain between 30-66% [5–10].
The surgical treatment of PP is primarily aimed at defining source control, followed by debridement of fibrin bedding and abdominal lavage of contaminants and infectious fluids. Nevertheless, the prognosis and outcome of patients with PP is directly related to early diagnosis and stringent treatment interventions. Recently, encouraging data have been published favoring a relaparotomy-on-demand strategy . Current criteria for performing relaparotomy are non-explicit and are based on non-quantitative, subjective arguments or hospital doctrines. Furthermore, it is known that failure of initial antibiotic therapy in patients with complicated intraabdominal infections is associated with higher mortality rates . Multiple scoring systems predicting the development of severe, life-threatening abdominal sepsis have been established but frequently fail to prognosticate the early onset of peritonitis and therefore miss the ideal time point for intervention. Reliable clinical parameters as well as precise diagnostic predictors which allow for precise detection of PP would thus be of paramount importance.
The aim of this retrospective study was to clarify the value of routinely used clinical and diagnostic parameters in early detection of PP compared to community acquired peritonitis (CAP). Furthermore, the prognosis and outcome after early indication for relaparotomy in patients with PP was evaluated.
Material and methods
A total of 251 patients with diffuse secondary peritonitis treated between May 1999 and April 2008 at the Department of Surgery, University of Schleswig-Holstein Campus Lübeck, were evaluated retrospectively. All consecutive cases within this time-frame were included. This group of patients comprised 114 individuals with PP and 137 patients with CAP, the latter serving as a control group.
All data regarding short and long term medical history, physical examination, MPI-score, APACHE II-score, laboratory values, imaging procedures (ultrasound, CT-scan, contrast-media imaging, mesenteric angiography), intraoperative findings, operative procedures and postoperative course were collected in our 'peritonitis-database' annually.
Diffuse secondary peritonitis was defined as intraoperative evidence of inflammation of the peritoneal surface and/or contaminants/infectious peritoneal fluid in all quadrants due to an intestinal perforation. CAP and PP were defined accordingly. In addition, PP was defined as a direct (e.g. anastomotic leakage) or indirect (e.g. perforated gastric ulcer after hemicolectomy) complication of a previously performed abdominal surgery. All cases of localized peritonitis were excluded. Furthermore, patients with suspected peritonitis but negative findings at the time of laparotomy were not included in the peritonitis database.
Diagnostic procedures in the case of suspected secondary diffuse peritonitis included abdominal ultrasound, CT-scan and radiological imaging using contrast-media as well as mesenteric angiography (when appropriate). Indication for relaparotomy after positive findings in CT-scan were based on the following citeria: Evidence of leakage, intraabdomnal air after more than five days postoperatively, and/or massive collection of intraabdominal fluid. The diagnostic significance was defined as 'correct' when correlating with intraoperative findings.
The APACHE II-score, the values for C-reactive protein (CRP), white blood cells (WBC), lactate and antithrombine III (AT III) were all documented daily for the first 7 days and twice a week thereafter until the patients were discharged.
The surgical treatment was primarily aimed at definitive source control, followed by gentle debridement of fibrin bedding and abdominal lavage with lactated Ringer's-solution and Polyhexanide. Relaparotomy was performed immediately following positive radiological examination and/or indicative clinical/laboratory signs. In PP, negative radiological findings and persistent symptoms of sepsis for longer than 24 hours were also indications for relaparotomy.
After the intraoperative diagnosis of secondary peritonitis, relaparotomy was performed every 24-48 hours on a scheduled basis (at least once), until intraoperative findings allowed for an abdominal closure. In case of dehiscent abdominal fascia, a Dexon®mesh was used.
To determine differences between the two groups (PP versus CAP), the χ2-test and Mann-Whitney U-test were used when appropriate. P < 0.05 was considered as being statistically significant. Statistical analyses were performed using Statistical Package for Social Science (SPSS®, version 12.0) for Windows (SPSS®, Chicago, Illinois, USA).
Characteristics of the study population: Biographical data and characteristics for PP and CAP groups
Multi organ failure
Statistical analyses revealed no significant differences regarding mortality and anatomic origin of sec ondary peritonitis between the two groups except for the appendix [4/17(CAP) vs. 0/3(PP), p = 0.01] and the hepatobiliary tract [2/7(CAP) vs. 8/10(PP), p = 0.03] (Figure 1b).
Clinical and paraclinical parameters: Differences in clinical and paraclinical parameters of CAP and PP patients
Abdominal rebound tenderness
18.0 (media n)
3.4 (media n)
AT III (%)
59.6% (media n)
25.7 (media n)
Diagnostic significance in PP
Imaging with contrast medium
Mesenteric angio graphy
The causes for peritonitis in the PP group were as follows: Anastomotic leakage 50.9% (n = 58), perforations 22.8% (n = 26), mesenteric ischemia 11.4% (n = 13) and others 14.9% (n = 17).
The number of abdominal lavages was significantly higher in the PP group (4.5 median) compared to the CAP group (2.5 median) (p = 0.009). In the CAP group one or two lavages were significantly more frequent than within the PP group (62.0% vs. 40.7%; p = 0.001). More than four lavages were performed more frequently in the PP group (27.4% vs. 10.2%; p < 0.001).
Early detection and diagnosis in secondary peritonitis, either postoperative or community-acquired, is critical for defining the most effective treatment intervention. Clinical monitoring should be aimed at early identification of the source of the complication before secondary organ failure aggravates the clinical situation. The complication itself does not frequently represent the major problem, but is more likely a consequence of late diagnosis and therefore of insufficient therapy. Thus the identification of early predictive indicators of peritonitis and abdominal sepsis is of utmost importance [10, 11, 13–16].
In our study we demonstrate that routinely used clinical and paraclinical parameters are of limited predictive value in the diagnosis of PP when compared to the group of patients with CAP. Slightly more than 50% of patients within the PP group presented with abdominal pain or tenderness to palpation accompanied by fever at the time of physical examination. Furthermore, clinical signs of peritonitis such as rigidity or rebound tenderness were only evident in 21.9% of these patients. This could be explained by the predominant post-aggression catabolism as well as by the postoperative administration of analgetic drugs . These patients are therefore frequently diagnosed after signs of sepsis have already occurred [5, 7, 10, 15, 17–19].
The low accuracy of physical tests in diagnosing postoperative peritonitis reflects the questionable value of a so-called 'experienced surgeon'. Of course, clinical judgment remains important but seems to frequently fail in times of effective postoperative analgesia and sedation of intubated patients [15, 19]. This is underlined by the fact that physical tests are not included in the 'top-ten ranked' variables for inpatient mortality of relaparotomy outcome in peritonitis patients . The current situation is thus that physical tests do not yield meaningful variables with respect to prediction of ongoing abdominal sepsis.
Analysis of laboratory infection parameters such as leukocytosis and C-reactive protein revealed no significant difference between the two groups. Furthermore, levels of AT III and lactate as parameters for mesenteric ischemia and coagulopathy within the course of sepsis were also not significantly different. Other diagnostic parameters such as interleukin 6 and tumor necrosis factor α (TNFα) levels are implicated as being important in the early onset of sepsis but do not correlate with outcome [20–22]. Moreover, their short half-lives make their diagnostic applicability questionable .
There has been great interest in the diagnostic and prognostic potential of procalcitonin in abdominal sepsis. Even though existing data support the sensitivity and specificity as an early marker for sepsis, its value is discussed controversial [8, 24, 25]. Recently, determination of procalcitonin levels in peritonitis was associated with a low sensitivity and specificity . In severe abdominal inflammation such as peritonitis, other sources such as catheter infections, pulmonary or urinary tract infections have to be taken into account in critically ill patients.
Once secondary peritonitis is suspected clinically, further investigations such as abdominal ultrasound and radiograph-based imaging techniques are necessary to confirm the presence and source of peritonitis. In our study the use of abdominal ultrasonography only revealed a sensitivity of 46%, possibly due to commonly occurring paralysis and/or meteorism of the intestines. Undoubtedly, mesentericography and radiograph imaging using contrast dyes have their value. Within this study, CT-scan revealed a sensitivity of 97.2% in detecting formation and source of peritonitis and was therefore the most precise and valuable imaging technique. Other studies support the utilization of CT-scanning in the diagnosis of secondary PP [27, 28].
An optimal scoring system should fulfill the following criteria: Objective, readily measurable under routine conditions, simple, easy available but also reliable, specific for the function of the organ considered and independent on the type of patient and therapeutic intervention. With the exception of the abdominal CT-scan, the investigated clinical and laboratory parameters unfortunately did not meet these criteria . Due to the retrospective character of the study only sensitivity and not specificity can be presented.
The mortality rate for patients within the PP group was 47.4% and therefore slightly higher than that for patients with CAP (35.8%, p = 0.060). The current literature reports mortality rates between 25 and 68% for secondary peritonitis, whereas the rates for the subgroup of PP unexceptionally exceed those for CAP [3–5, 11, 29]. Even though there is a trend towards higher mortality in the PP group, rates did not differ significantly from the CAP group, which is a novel finding. Thus our results do not support an observation strategy in uncertain cases of peritonits without pathological findings on CT-scan as it has been advocated by others [14, 30]
The lack of statistical difference in mortality rates between the two groups are probably caused by the most early intervention, even in doubtful cases. The significantly higher number of lavages necessary in the PP group indicates that these patients are either diagnosed too late (despite most early indication for relaparotomy) or are more susceptible to bacteraemia due to predominant immunosuppression. Nevertheless, the re-laparotomy strategy was not an outcome measure in this study. Thus, no clear recommendations can be given from our data.
There is no ideal control group for patients with diffuse PP to assess the value of diagnostic parameters. A comparison with uncomplicated recovering patients having undergone elective abdominal surgery would give apparently clear results but would not reflect the group of importance - postoperative patients in the ICU in critical condition with the question of whether to perform relaparotomy or not. We therefore consider the group of patients with diffuse CAP to be the most appropriate due to the comparable extent of peritonitis and the severity of sepsis signs. The separation between diffuse CAP and PP is undoubtfully artificial. It might be more appropriate to compare patients with surgically proven peritonitis and patients suspicious for peritonitis but without surgical findings at the time of laparotomy. Due to the retrospective character of this study it is almost impossible to re-evaluate the latter group. Evaluating on the other hand - this more "ideal" study collective in a randomized controlled setting might increase the clinical awareness and therefore leading to an evaluation bias. Nevertheless, earlier diagnosis and consecutive treatment in these patients is frequently performed because of the more frequently apparent clinical symptoms. This has to be taken into account critically for the assessment of the results revealed by this study.
Despite advances in intensive care support, scoring systems and sophisticated markers, early diagnosis of generalized PP remains difficult. In our study, clinical and laboratory parameters were of limited value in the early diagnosis of PP. The most reliable imaging technique was the CT-scan. Only interventions prior to sepsis onset and development of MOF can reduce morbidity and mortality. We thus favour early relaparotomy even in suspected cases of PP as being the appropriate timepoint for intervention.
Prof. Robert Harris, Karolinska Institutet, Stockholm is greatefully acknowledged for critical reviewing the manuscript and his helpful comments.
- Kujath P, Rodloff A: Peritonitis. Second edition. Bremen, London, Boston, UNIMED; 2005:36–41.Google Scholar
- Buchler MW, Baer HU, Brugger LE, Feodorovici MA, Uhl W, Seiler C: [Surgical therapy of diffuse peritonitis: debridement and intraoperative extensive lavage]. Chirurg 1997, 68: 811–815. 10.1007/s001040050276PubMedView ArticleGoogle Scholar
- Pacelli F, Doglietto GB, Alfieri S, Piccioni E, Sgadari A, Gui D, Crucitti F: Prognosis in intra-abdominal infections. Multivariate analysis on 604 patients. Arch Surg 1996, 131: 641–645. 10.1001/archsurg.1996.01430180067014PubMedView ArticleGoogle Scholar
- Pusajo JF, Bumaschny E, Doglio GR, Cherjovsky MR, Lipinszki AI, Hernandez MS, Egurrola MA: Postoperative intra-abdominal sepsis requiring reoperation. Value of a predictive index. Arch Surg 1993, 128: 218–222. discussion 223 10.1001/archsurg.1993.01420140095015PubMedView ArticleGoogle Scholar
- Anderson ID, Fearon KC, Grant IS: Laparotomy for abdominal sepsis in the critically ill. Br J Surg 1996, 83: 535–539. 10.1002/bjs.1800830434PubMedView ArticleGoogle Scholar
- Kirschner : Die Behandlung der akuten eitrigen freien Bauchfellentzündung. Arch klin Chir 1926, 142: 253–311.Google Scholar
- McLauchlan GJ, Anderson ID, Grant IS, Fearon KC: Outcome of patients with abdominal sepsis treated in an intensive care unit. Br J Surg 1995, 82: 524–529. 10.1002/bjs.1800820429PubMedView ArticleGoogle Scholar
- Rau BM, Frigerio I, Buchler MW, Wegscheider K, Bassi C, Puolakkainen PA, Beger HG, Schilling MK: Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study. Arch Surg 2007, 142: 134–142. 10.1001/archsurg.142.2.134PubMedView ArticleGoogle Scholar
- Unalp HR, Kamer E, Kar H, Bal A, Peskersoy M, Ali Onal M: Urgent abdominal re-explorations. World J Emerg Surg 2006, 1: 10. 10.1186/1749-7922-1-10PubMed CentralPubMedView ArticleGoogle Scholar
- van Ruler O, Lamme B, Gouma DJ, Reitsma JB, Boermeester MA: Variables associated with positive findings at relaparotomy in patients with secondary peritonitis. Crit Care Med 2007, 35: 468–476. 10.1097/01.CCM.0000253399.03545.2DPubMedView ArticleGoogle Scholar
- Lamme B, Boermeester MA, Belt EJ, van Till JW, Gouma DJ, Obertop H: Mortality and morbidity of planned relaparotomy versus relaparotomy on demand for secondary peritonitis. Br J Surg 2004, 91: 1046–1054. 10.1002/bjs.4517PubMedView ArticleGoogle Scholar
- Edelsberg J, Berger A, Schell S, Mallick R, Kuznik A, Oster G: Economic consequences of failure of initial antibiotic therapy in hospitalized adults with complicated intra-abdominal infections. Surg Infect (Larchmt) 2008, 9: 335–347. 10.1089/sur.2006.100View ArticleGoogle Scholar
- Lamme B, Mahler CW, van Ruler O, Gouma DJ, Reitsma JB, Boermeester MA: Clinical predictors of ongoing infection in secondary peritonitis: systematic review. World J Surg 2006, 30: 2170–2181. 10.1007/s00268-005-0333-1PubMedView ArticleGoogle Scholar
- Marshall JC, Innes M: Intensive care unit management of intra-abdominal infection. Crit Care Med 2003, 31: 2228–2237. 10.1097/01.CCM.0000087326.59341.51PubMedView ArticleGoogle Scholar
- Mulier S, Penninckx F, Verwaest C, Filez L, Aerts R, Fieuws S, Lauwers P: Factors affecting mortality in generalized postoperative peritonitis: multivariate analysis in 96 patients. World J Surg 2003, 27: 379–384. 10.1007/s00268-002-6705-xPubMedView ArticleGoogle Scholar
- van Ruler O, Mahler CW, Boer KR, Reuland EA, Gooszen HG, Opmeer BC, de Graaf PW, Lamme B, Gerhards MF, Steller EP, van Till JW, de Borgie CJ, Gouma DJ, Reitsma JB, Boermeester MA: Comparison of on-demand vs planned relaparotomy strategy in patients with severe peritonitis: a randomized trial. Jama 2007, 298: 865–872. 10.1001/jama.298.8.865PubMedView ArticleGoogle Scholar
- Makela J, Kairaluoma MI: Relaparotomy for postoperative intra-abdominal sepsis in jaundiced patients. Br J Surg 1988, 75: 1157–1159. 10.1002/bjs.1800751204PubMedView ArticleGoogle Scholar
- Hinsdale JG, Jaffe BM: Re-operation for intra-abdominal sepsis. Indications and results in modern critical care setting. Ann Surg 1984, 199: 31–36. 10.1097/00000658-198401000-00006PubMed CentralPubMedView ArticleGoogle Scholar
- Holzheimer RG, Gathof B: Re-operation for complicated secondary peritonitis -how to identify patients at risk for persistent sepsis. Eur J Med Res 2003, 8: 125–134.PubMedGoogle Scholar
- Fang XM, Schroder S, Hoeft A, Stuber F: Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 1999, 27: 1330–1334. 10.1097/00003246-199907000-00024PubMedView ArticleGoogle Scholar
- Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J: Diagnostic value of pro-calcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001, 164: 396–402.PubMedView ArticleGoogle Scholar
- Majetschak M, Flohe S, Obertacke U, Schroder J, Staubach K, Nast-Kolb D, Schade FU, Stuber F: Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg 1999, 230: 207–214. 10.1097/00000658-199908000-00011PubMed CentralPubMedView ArticleGoogle Scholar
- Reith HB, Mittelkotter U, Debus ES, Kussner C, Thiede A: Procalcitonin in early detection of postoperative complications. Dig Surg 1998, 15: 260–265. 10.1159/000018625PubMedView ArticleGoogle Scholar
- Reith H, Mittelkötter U, Wagner R, Thiede A: Procalcitonin (PCT) in patients with abdominal sepsis. Intensive Care Med 2000,26(suppl2):159–164.Google Scholar
- Schroder J, Staubach KH, Zabel P, Stuber F, Kremer B: Procalcitonin as a marker of severity in septic shock. Langenbecks Arch Surg 1999, 384: 33–38. 10.1007/s004230050170PubMedView ArticleGoogle Scholar
- Lam MF, Leung JC, Lam CW, Tse KC, Lo WK, Lui SL, Chan TM, Tam S, Lai KN: Procalcitonin fails to differentiate inflammatory status or predict long-term outcomes in peritoneal dialysis-associated peritonitis. Perit Dial Int 2008, 28: 377–384.PubMedGoogle Scholar
- Evans HL, Raymond DP, Pelletier SJ, Crabtree TD, Pruett TL, Sawyer RG: Diagnosis of intra-abdominal infection in the critically ill patient. Curr Opin Crit Care 2001, 7: 117–121. 10.1097/00075198-200104000-00010PubMedView ArticleGoogle Scholar
- Rotstein OD, Meakins JL: Diagnostic and therapeutic challenges of intraabdominal infections. World J Surg 1990, 14: 159–166. 10.1007/BF01664868PubMedView ArticleGoogle Scholar
- Nathens AB, Rotstein OD, Marshall JC: Tertiary peritonitis: clinical features of a complex nosocomial infection. World J Surg 1998, 22: 158–163. 10.1007/s002689900364PubMedView ArticleGoogle Scholar
- Marshall JC, Vincent JL, Fink MP, Cook DJ, Rubenfeld G, Foster D, Fisher CJ Jr, Faist E, Reinhart K: Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25–26, 2000. Crit Care Med 2003, 31: 1560–1567. 10.1097/01.CCM.0000065186.67848.3APubMedView ArticleGoogle Scholar