Open Access

A comparative study of perfusion CT and 99mTc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion

  • S. Eicker1Email author,
  • B. Turowski2,
  • H.-J. Heiroth1,
  • H.-J. Steiger1 and
  • D. Hänggi1
European Journal of Medical Research201116:484

https://doi.org/10.1186/2047-783X-16-11-484

Received: 8 March 2011

Accepted: 5 May 2011

Published: 10 November 2011

Abstract

Background and purpose

Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a predictor in the diagnostic pathway in patients considered for cerebral revascularization. Recently perfusion CT (PCT) gained widely acceptance in stroke imaging The present study was aimed at comparing the results of perfusion CT (PCT) and 99mTc-HMPAO SPECT with acetazolamide challenge in patients with ICA occlusion.

Methods

13 patients were included in the prospective evaluation. Both PCT and 99mTc-HMPAO SPECT were performed before and after the administration of acetazolamide. In detail, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), adapted time to peak (Tmax) and mean transit times (MTT) were compared with SPECT data.

Results

99mTc-HMPAO SPECT demonstrated an impairment of CVR in six patients. A preserved CVR was present in seven patients. All patients with impaired CVR proven by SPECT had a delayed MTT (mean +2.98 s) and a delayed Tmax (mean + 5.9 s), (both p < 0.005 compared with the non occluded side). 66% of patients with impaired CVR in SPECT showed a complete correlation of Tmax measurements in PCT with a high positive predictive value (PPV: 88.8%).

Conclusion

The prospective study demonstrated a highly significant correlation of perfusion parameters as' detected by 99mTc-HMPAO SPECT and the Tmax as detected by PCT in patients with ICA occlusion. Therefore this easy-to-perform technique seems to be an adequate method for the evaluation of cerebral perfusion in patients with ICA occlusion.

Keywords

cerebral vascular reserve perfusion CT SPECT internal carotid artery occlusion

Introduction

Patients suffering from internal carotid artery (ICA) occlusive disease can show a remarkable but individually variable risk of subsequent stroke. The annual risk of stroke was estimated at 5.5% per year and accentuated in patients with additional compromised cerebral blood flow [1, 21]. Therefore, besides clinical symptoms the impairment of the cerebral vascular reserve (CVR), which reflects the capacity to maintain adequate blood flow in the face of decreased perfusion pressure, has been identified as the major predictive indicator for the risk of subsequent cerebral infarction [1]. Since improvement of CVR can be achieved by extra-intracranial (EC-IC) bypass surgery, it is important to identify patients with perfusion impairment [2]. In recent years several techniques have been established to determine CVR comprising single photon emission computed tomography (SPECT) [3], transcranial Doppler (TCD) ultrasound [4], perfusion magnetic resonance imaging (MRI) [57], positron emission tomography (PET) [8] and Xenon computed tomography (CT) [9]. Nowadays SPECT analysis with and without acetazolamide (Diamox®) challenge is widely regarded as gold standard in the diagnostic pathway of patients with ICA occlusive disease and assumed reduction of CVR. Nonetheless, this examination has some disadvantages: First, due to tracer kinetics it has to be performed on two days [14]. Second, the analysis of the examination must be regarded as semiquantitative [6]. Finally, SPECT provides less morphological information compared to MRI and to regular CT. The goal of the present study was to correlate perfusion CT (PCT) examinations in patients with ICA occlusion with 99mTc-HMPAO SPECT in the evaluation of the cerebral CVR. To the best of our knowledge a comparison of PCT and 99mTc-HMPAO SPECT as presented in the study has hereby been performed for the first time.

Methods

Patient Population

Patients suffering from symptomatic arteriosclerotic ICA occlusion and Moyamoya disease considered for cerebral revascularization were included in this prospective single center study. Criteria for exclusion were age under 18 years and a time interval between PCT and 99mTc-HMPAO SPECT of longer than one week. All patients had given informed consent.

PCT Protocol

PCT was performed using a multislice CT Scanner (Yolume Zoom, Siemens Erlangen/Germany, 80,0 kY, 120 mAs, 1 scan per second, over-all duration 35 s). Patients were examined before and after acetazolamide application (Diamox®, 1000 mg i.v. over 2 min) the same day. For each examination patients received a single bolus of 30 ml contrast agent intravenously (400 mg iodine/ml) equalizing a total iodine dose of 12 g. Two slices with a slice thickness of 10 mm representing all three supratentorial vascular territories were obtained. Raw data was transferred to a workstation for further processing. Analysis comprising determination of mean transit time (MTT), regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and adapted time to peak (Tmax) was carried out by STROKETOOL-CT software (Version 2.0) [10]. Compared to time to peak (TTP)-based measurements Tmax analysis allows minimizing the influence of extracerebral conditions such as circulation time [11]. Perfusion maps were further evaluated by use of the computer software Angiotux CT 2D [11] as previously described. For each hemisphere the mean values of all four perfusion parameters in 18 overlapping defined cortical segments (equalizing sections of 10° intersection 2°) were determined. All segments were related to vascular territories: An occipital 30° segment corresponds to the vascular territory of the posterior cerebral artery, the adjacent 20° section to the posterior border zone. The following 90° segment correspond to the vascular territory of the middle cerebral artery, 20° to the anterior border zone and the vascular territory of the anterior cerebral artery each. Data were displayed as a so-called angle plot with the anatomical localization on the × coordinate and the perfusion parameters on the y coordinate and as mean values of each cerebral hemisphere. The resulting diagram allowed comparing perfusion parameters before and after acetazolamide stress. CVR calculation was carried out in two different ways: On the one hand on the basis of rCBF data by use of the following formula: increase (%) = [(post-rCBF)-(pre-rCBF)]/(prerCBF) × 100% whereas pre- and post-data refer to acetazolamide administration [6]. A difference in CBF between the occluded and non-occluded side of more than 10% was defined as impaired CYR (according to SPECT evaluations). On the other hand CVR estimation was performed on the basis of delayed MTT and Tmax. An increasing fraction of Tmax and MTT-values above a threshold of 3.5 s after acetazolamide indicated depletion of CVR.

99mTc-HMPAO SPECT Imaging Protocol

All patients were examined with the identical 2-day protocol with a maximum of one day between the two examinations. Measurement of brain perfusion was performed using stabilized exametazime (99mTc-HMPAO) and SPECT. Image acquisition was initiated 20 min after injection of about 536 MBq (range 500-670 MBq) stabilized exametazime. Acetazolamide was intravenously administered over 2 minutes during the stress examination. 15 min after acetazolamide infusion 99mTc-HMPAO was slowly injected. Patients were examined in a supine position with the head in head holders. For image acquisition, a Philips Prism 2000 XP double-head gamma camera (Marconi plc, London, England) was used. Further evaluation was carried out once the data had been transferred to a workstation. Analysis of all studies was carried out by visual interpretation and by comparison of ROIs in both hemispheres. Impairment of CVR in 99mTc-HMPAO SPECT imaging was defined as a rCBF restriction of more than 10% in the occluded side compared to the non-occluded side. In reverse a difference in rCBF less than 10% was defined as preserved CVR [6].

Statistical Analysis

Statistical analysis comparing the PCT data (occluded vs. non occluded side) was performed by use of a Wilcoxon rank-sum test. This test was also applied to compare the 99mTc-HMPAO SPECT data with the PCT (SPSS, Version 16.0.1, Chicago). The positive predictive value (PPV) was calculated using the formula: number of right positive values/(number of right-positive values + number of wrong-positive values).

Results

Patients

13 patients (five males and eight females) aged between 18 and 69 years (average age: 50.3 years) were included in the evaluation. In all patients we received comparable examinations (7 before and 6 after bypass surgery). A total of 13 parallel examinations were performed. Symptomatic unilateral ICA occlusion (8 patients; 3 right-sided and 5 left-sided), Moyamoya disease (4 patients) and symptomatic unilateral ICA/MCA occlusion (1 patient) were enclosed. All patients had symptoms of cerebrovascular or carotid artery disease before performing an EC-IC bypass. One patient presented in our clinic after bypass surgery for a check-up. 7 patients suffered from general arterial occlusive disease. Other cerebrovascular risk factors (arterial hypertension, hypercholesterolemia and diabetes mellitus) were present in 8 patients. One patient displayed a cerebral aneurysm: a unilateral anterior cerebral artery (ACA) aneurysm.

11 EC-IC bypass surgeries were performed. One patient underwent EC-IC bypass surgery on both symptomatic sides with a time lag of three months. Five high-flow bypass surgeries and one medium-flow bypass surgery with autogenetic radial artery graft, one barrel EC-IC bypass surgery (parietal and frontal branches of the superficial temporal artery) and four standard EC-IC bypass surgeries were completed in our department. In all patients a preoperative and postoperative study including cerebral angiography, CT, MRI (preoperative) and a perfusion imaging with and without stress simulation was performed. In 7 patients we received comparable examinations (99mTc-HMPAO SPECT/PCT) before and in 6 patients after bypass surgery. PCT and 99mTc-HMPAO SPECT were usually performed within 4 days. Patients' data are summarized in Table 1.

Table 1

Detailed data of the 13 patients (compared examinations are framed). Impaired or preserved CVR in PCT is based on Tmax calculation.

Patient no.

Age (years

Sex

Symptomes

DSA

Prestudy MRI

CVR

 

Treatment

DSA after surgery

CVR after treatment

 

Clinical findings after surgery

      

SPECT

PCT

  

SPECT

PCT

 

1

56

w

Recurrent hemiparesis right, recurrent aphasia

ICA occlusion left

Small stroke

Impaired

Impaired

High-flow EC-IC bypass left-sided

Bypass patient

 

Impaired

Stable

2

69

m

Recurrent hemiparesis left, left handed

ICA occlusion right, ICA occlusion left (40-50%)

Multiple small strokes

Preserved

 

Standard EC-IC bypass right-sided

Bypass patient

Preserved

Impaired

Improved

3

27

w

Left EC-IC bypass in 2002. No symptoms

ICA occlusion left

Small, stroke

Preserved

Preserved

Standard EC-IC bypass right-sided

Bypass patient

  

Stable

4

51

w

Vertigo, recurrent hemihypasthesia (TIA)

ICA occlusion right & left

Small stroke

Impaired

 

Standard EC-IC bypass right-sided

Bypass patient

Impaired

Impaired

Improved

5

18

w

Recurrent left hemihypasthesia (TIA), recurrent aphasia

ICA stenosis right

No stroke

Impaired

 

Standard EC-IC bypass right-sided

Bypass patient

Preserved

Preserved

Improved

6

56

m

Hemiparesis and hemihypasthesia right, aphasia

ICA occlusion right & left

Small stroke

Impaired

 

High-flow EC-IC bypass left-sided

Bypass patient

Preserved

Preserved

Stable

7

56

w

Impaired vision, diplopic images

ACI aneurysma & ICA stenosis left

ACI aneurysma

Impaired

 

Standard EC-IC bypass left-sided, trapping ACI giant aneurysma

Bypass patient

Preserved

Preserved

Stable

8

51

w

Recurrent hemiparesis left

ICA occlusion right

Right-sided Stroke MCA

Impaired

 

Standard EC-IC bypass right-sided

Bypass patient

Preserved

Preserved

Stable

9

53

w

Recurrent aphasia and hypaesthesia right

ICA/MCA stenosis left

Small stroke

Impaired

Impaired

High-flow EC-IC bypass left-sided

Bypass patient

  

Stable

10

59

m

Impaired vision, recurrent aphasia, syncope

ICA occlusion right & left

No stroke

Impaired

Impaired

High-flow EC-IC bypass left-sided

Bypass patient

  

Stable

11

59

m

Hemiparesis right, recurrent aphasia

ICA stenosis right & left

Left-sided Stroke

Impaired

Impaired

High-flow EC-IC bypass left-sided

Bypass patient

  

Stable

12

38

w

Hemihypasthesia (TIA) left

ICA stenosis right

No stroke

Preserved

Preserved

 

Bypass patient

  

Stable

13

61

m

Hemiparesis right, transient aphasia

ICA stenosis right & left; A. vertebral is stenosis [22]

Small stroke

Impaired

Impaired

High-flow EC-IC bypass left-sided

Bypass patient

  

Stable

99mTc-HMPAO SPECT Results

An impairment of CVR was found by 99mTc-HMPAO SPECT in six analyses whereas a preservation of CVR was present in seven examinations. Table 2 gives you an overview over the examined patients in detail.
Table 2

Impaired and preserved CVR in 99mTc-HMPAO SPECT analyses.

Impaired CVR in SPECT

Preserved CVR in SPECT

-Unilateral ICA occlusion

1 - Unilateral ICA occlusion, 3

-Moyamoya disease

1 - Moyamoya disease 3

-Bilateral ICA occlusion *

3 - Bilateral ICA occlusion * 1

-ICA/MCA occlusion

1 - ICA/MCA occlusion -

* One symptomatic hemisphere

Figure 1

Brain map devided into 36 segments and the six analysed vascular terretories.

Figure 2

Patient no. 1 (further details see Table 1) with left sided ICA occlusion. Significant impairment of CVR can be detected by 99mTc-HMPAO SPECT. a-e show 99mTc-HMPAO SPECT and PCT images before acetazolamide administration. f-j illustrates 99mTc-HMPAO SPECT and PCT images after acetazolamide administration. The 99mTc-HMPAO SPECT images (a, f) demonstrate impairment in the left parietal and occipital lobes. Tmax (b, g) and MTT (c, h) measurements show a delay in the parietooccipital territories after acetazolamide (g, h). No significant difference before and after acetazolamide administration can be detected in the perfusion measurement regarding CBV (d, i) and CBF (e, j).

RCBF And rCBV Results

Four patients with unilateral ICA occlusion showed a decrease of rCBF in the PCT analysis on the occluded side without significant difference to the non-occluded side. One patient with unilateral ICA occlusion and reduced CVR in 99mTc-HMPAO SPECT displayed a 49.6% increase of rCBF in PCT on the occluded side (an asymptomatic stenosis on the contralateral side was known). One patient with ICA occlusion of the right side and asymptomatic carotid artery stenosis on the left and preserved CVR in 99mTc-HMPAO SPECT presented with a 202.2% decrement in rCBF on the right hemisphere in comparison to the contralateral side.

In the subgroup of Moyamoya disease one patient displayed an impairment of CYR in SPECT. This patient presented with an incremented rCBF of the symptomatic hemisphere, without statistical significance in comparison to the contra lateral side. Two patients with Moyamoya disease and with preserved CVR in 99mTc-HMPAO SPECT showed completely different results of rCBF: one presented with an increase by 86% and another with a decrease by 60.6% (comparison of the occluded and the less or non-occluded side). The patient with ICA/MCA occlusion presented with an incremented rCBF, which was not statistically significant compared to the non-occluded side.

RCBV measurements also showed heterogeneous results similar to the rCBF measurements.

CVR calculation on the basis of rCBF provided the following results:

Five of the six patients with impaired CVR in 99mTc-HMPAO SPECT also had impaired CVR in the PCT studies. One patient without correlation (preserved CVR in PCT regarding rCBF) showed symptomatic ICA/MCA occlusion. Five patients with preserved CVR in 99mTc-HMPAO SPECT imaging were detected in the rCBF imaging with an impaired CVR (two patients with Moyamoya, one with bilateral ICA occlusion and two patients with unilateral ICA occlusion). Therefore, no significant correlation of SPECT and PCT data could be detected in the group with preserved CVR.

MTT and Tmax Results

An increasing fraction of MTT-values above a threshold of 3.5 s after acetazolamide was defined as impaired CVR.

According to our definition, a CVR was seen as preserved if more than 50% of regions of interest (ROIs) were below this critical value. For better comparison with 99mTc-HMPAO SPECT imaging, the 36 cortical segments analyzed in PCT were pooled to six vascular territories; the posterior cerebral artery (PCA) territory, the MCA territory and the ACA territory bilateral. As a result, a significant correlation between Tmax and 99mTc-HMPAO SPECT was detected. This correlation was not evident in the comparison of rCBF and 99mTc-HMPAO SPECT. MTT and Tmax measurement yielded the following results. In the overall patient cohort, MTT was delayed by 3.8 s (SD: 2.7) and Tmax was delayed by 11.92 s (SD:' 7.3) on the occluded side (mean values). Patients with impaired CVR proven by 99mTc-HMPAO SPECT showed a delayed MTT (mean +2.98 s; SD: 2.7) and a delayed Tmax (mean + 5.9 s; SD: 4.1). These findings were statistically significant with regard to the frontal and parietal vascular territories, i.e. MCA and ACA (all p < 0.005 compared with the non occluded side). However, in the posterior vascular territory we found differences that had no statistical significance.

According to our definition only Tmax values had an increasing fraction above a threshold of 3.5 s after acetazolamide in all subgroups witch indicated depletion of CVR.

These Tmax measurements and SPECT data showed a positive correlation. 66% of patients with impaired CVR in SPECT showed a complete consistency in Tmax measurements in the analyzed six territories in PCT (p = 1). In six of the remaining patients we found an absolute correlation in five of six territories. Only one patient had a positive matching just in three of six territories. The precision rate for Tmax was high (88.8%).

Discussion

A number of different techniques to determine cerebral perfusion in patients with occlusive carotid artery disease have been described. SPECT, TCD ultrasound, perfusion MRI, PET, Xenon CT with acetazolamide or CO2 challenge have proven to be suitable methods in the assessment of CVR [12, 13]. In general, SPECT is widely used as the standard technique. 15O-PET has been reported reliable since it provides information not only about hemodynamic but also about metabolic parameters (i.e. oxygen utilization and oxygen extraction fraction) [14]. However, this procedure is limited to capacious diagnostic facilities. SPECT with acetazolamide stress is disadvantageous that examinations have to be performed in the course of two days due to tracer kinetics (a 1-day procedure is generally possible but is associated with an increase of radiation exposure for the patient as previously described) [15]. Furthermore, SPECT can merely provide vague morphological information compared with PCT or perfusion MRI [6].

PCT studies before and after acetazolamide administration can be performed on one within 30 minutes. CT images provide more morphological details [16, 17].

PCT is well established in the diagnostic pathway of stroke [1]. Recently, this examination has been reported as a predictor for secondary cerebral infarction in patients with subarchnoidal hemorrhage (SAH) [18, 19]. Encouraged by this data we hypothized that PCT can be used for the assessment of CVR with acetazolamide challenge in an analogous way to SPECT. To our knowledge a comparative analysis of PCT and 99mTc-HMPAO SPECT has not been performed so far. For the first time we compared PCT data with 99mTc-HMPAO SPECT data in a prospective, non-randomized setting.

One limitation of the study is the small number of patients (n = 13). The second restriction is the SPECT data acquisition, which was carried out in a semiquantitative matter as opposed to the quantitative PCT data collection. Therefore the detailed PCT information had to be reduced to obtain comparable measurements. A third limitation is the heterogeneous patient collective. We evaluated patients with Moyamoya disease as well as patients with ICA occlusion and even one patient with ICA/MCA occlusion.

The present study shows a significant difference in Tmax and MTT measurements on the occluded vs. the non occluded side in the frontal and parietal region. The difference in the posterior territories was not significant and could be associated with the tentorial edge and a less precise representation of the posterior supratentorial vascular territory in the measurements. Of course it can be also attributed to a lack of stenosis in the vertebro-basilar circulation. Nonetheless, the present study shows no clear correlation of PCT and SPECT regarding the rCBF and rCBV. This can be attributed to the heterogeneous patient collective and the small number of patients. However, we found a considerable correlation of Tmax measurement and SPECT without a difference in the subpopulations, as opposed to other examinations in which a correlation of MTT and SPECT was detected [6, 20]. This could be due to the modified and more precise Tmax [11] data compared to the more frequently used TTP. According to our examinations, PCT can identify impairment of CVR in patients with symptomatic carotid artery occlusion in the acetazolamide stress test and corresponds favorably to 99mTc-HMPAO SPECT data. In the present study, Tmax data seems to be a suitable parameter for CVR estimation using the definitions of delayed Tmax as described above (precision rate of 88.8% to identify patients with preserved CVR).

Compared to SPECT, PCT provides additional morphological and hemodynamic information. Furthermore it is more readily accessible. Consequently PCT appears to be an adequate method to identify patients with impaired CVR prior to bypass surgery, However, this remains to be supported by prospective investigations with a larger patient cohort and quantitative SPECT data.

Conclusions

The present non-randomized, prospective study demonstrated a highly significant correlation of the perfusion parameters as detected by 99mTc-HMPAO SPECT and the Tmax as detected by PCT in patients with ICA occlusion. Therefore the easy-to-perform PCT examination seems to be an adequate method for the evaluation of cerebral perfusion in patients with ICA occlusion.

Conflict of interest Statement

The authors declare that they have no competing interests.

Authors’ Affiliations

(1)
Department of Neurosurgery, Heinrich-Heine-University
(2)
Department of Neuroradiology, Heinrich-Heine-University

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© I. Holzapfel Publishers 2011