- Open Access
Cardiac computed tomography in patients with symptomatic new-onset atrial fibrillation, rule-out acute coronary syndrome, but with intermediate pretest probability for coronary artery disease admitted to a chest pain unit
European Journal of Medical Research volume 23, Article number: 6 (2018)
Atrial fibrillation (AF) and coronary artery disease (CAD) may be encountered coincidently in a large portion of patients. However, data on coronary artery calcium burden in such patients are lacking. Thus, we sought to determine the value of cardiac computed tomography (CCT) in patients presenting with new-onset AF associated with an intermediate pretest probability for CAD admitted to a chest pain unit (CPU).
Calcium scores (CS) of 73 new-onset, symptomatic AF subjects without typical clinical, electrocardiographic, or laboratory signs of acute coronary syndrome (ACS) admitted to our CPU were analyzed. In addition, results from computed tomography angiography (CTA) were related to coronary angiography findings whenever available.
Calcium scores of zero were found in 25%. Median Agatston score was 77 (interquartile range: 1–270) with gender- and territory-specific dispersal. CS scores above average were present in about 50%, high (> 400)-to-very high (> 1000) CS scores were found in 22%. Overall percentile ranking showed a relative accordance to the reference percentile distribution. Additional CTA was performed in 47%, revealing stenoses in 12%. Coronary angiography was performed in 22% and resulted in coronary intervention or surgical revascularization in 7%. On univariate analysis, CS > 50th percentile failed to serve as an independent determinant of significant stenosis during catheterization.
Within a CPU setting, relevant CAD was excluded or confirmed in almost 50%, the latter with a high proportion of coronary angiographies and subsequent coronary interventions, underlining the diagnostic value of CCT in symptomatic, non-ACS, new-onset AF patients when admitted to a CPU.
Acute chest pain with potentially life-threatening conditions is commonly encountered in emergency departments, and the need for prompt and accurate diagnosis has led to the establishment of chest pain units (CPUs) . Within the CPU processes, efforts in optimizing patients’ care also address to the low-risk troponin-negative subset, including the establishment of noninvasive diagnostic work-up in selected patients. Still, coronary artery disease (CAD) leading to myocardial ischemia is the most common cause for admission to a CPU. However, CPUs are often also supposed to take care of patients with the first onset of atrial fibrillation (AF), especially when associated with symptoms suggestive of ischemia . As much as 25% of patients with CAD also exhibit AF; conversely, AF occurs in 2–21% of patients with ACS [3, 4]. Determining pretest risk assessment of coronary artery calcification (CAC) for risk stratification in CAD has been a subject of intensive investigation. CAC scanning has emerged as a robust predictor for coronary events in subjects with an intermediate pretest probability for CAD [5, 6]. A higher CAC burden carries a greater risk for future CAD events and all-cause mortality, thereby appropriately reclassifying a majority of patients into low- and high-risk categories. The Agatston score has been developed as an attempt to reflect a marker for the quantity and location of CAC within the coronary artery circulation, and has attracted a considerable body of research and clinical attention with further imaging improvements over the recent years [5, 7, 8].
Registry data revealed that cardiac computed tomography (CCT) is currently underrepresented in the diagnostic work-up in certified CPUs in Germany despite its high negative predictive power . The present update of the certification criteria now points toward the benefit of cardiac CT angiography, but still provides no mandatory rules for its use in selected patients . So far, data on CAC burden in patients with the first diagnosed, symptomatic AF and an intermediate pretest probability for CAD are missing. The aim of our study was to analyze the clinical value of CCT in the aforementioned patient population within the CPU concept.
We reviewed our CCT imaging database and retrospectively included patients who presented during a 2-year-period (from October 2012 to September 2014) to the CPU at our institution. By institutional CPU protocol, CCT was performed in case of the new-onset AF associated with acute atypical chest pain and an intermediate pretest probability for coronary stenosis; if otherwise, coronary angiography should have been used and in case of low-to-intermediate pretest probability for coronary stenosis if ergometry (as the local stress test of first choice) remained nondiagnostic or could not be performed due to various reasons . Atypical chest pain was defined as nonanginal thoracic discomfort not precipitated by physical exertion or emotion. AF was defined according to the current ESC guidelines for the management of AF [12, 13]. Major exclusion criteria were initial triage as acute coronary syndrome (ACS), clinical presentation with typical angina pectoris, preexisting CAD, preexisting AF, new diagnostic ischemic changes on the initial ECG, initial troponin exceeding the 99th percentile of the local assay with a relevant dynamic rise or fall suggestive for ischemia, and positive stress test indicating reversible ischemia. Within our clinical setting, there were no given exclusion criteria for the assessment of CAC except for patients’ refusal. Exclusion criteria for CCT angiography comprised: pregnancy, renal failure with a glomerular filtration rate below 45 ml/min/1.73 m2 and known allergy on contrast agents. Patients with overt or subclinical hyperthyroidism as well as patients with valvular AF were also excluded. At the time of image acquisition, all eligible patients had sinus rhythm following spontaneous, medical, or electrical cardioversion.
Cardiac computed tomography scans were performed using a 128-slice CT scanner (Aquilion CX, Toshiba Medical Systems, Tokyo, Japan).
Calcium scoring (CS)
CTs were acquired in a single-slice axial scan from the base to the apex with an image acquisition time of 350 ms. A slice thickness of 3 mm was chosen. Prospective ECG triggering was performed at 80% of the R–R interval. The CAC score was determined according to the methods of Agatston et al.  and expressed in Hounsfield units. At least four contiguous pixels with a CT density of ≥ 130 Hounsfield units were used to define an area of CAC. Total CAC scores comprising all calcified coronary lesions as well as regional CAC scores for left main (LM), left anterior descending artery (LAD), left circumflex artery (LCX) and right coronary artery (RCA) were computed. Percentile ranking was performed on the basis of the German population-based Heinz Nixdorf Recall study . Binary subgroup analysis were done for patients with CS = 0 versus CS > 0. In addition, descriptive analysis comprised patients over the 50th percentile declared as above average.
Computed tomography angiography (CTA)
By protocol, patients with a CS of > 0 and < 400 were assessed by additional CTA. In case of diffuse calcifications of the entire coronary tree, selected patients with a CS of slightly beyond 400 may also have been triaged to subsequent CTA according to the clinical decision made by the attending physician. Image acquisition was performed with a collimation of 2 × 64 × 0.5 mm and a reconstruction interval of 0.3 mm (scanner settings: 120 kv and dynamic 350–450 mA, gantry rotation time: 350 ms, helical pitch: 34.2, pitch factor: 0.53). 80 ml of contrast medium (Iomeron 400 mg/ml, Bracco Imaging, Milan, Italy) were injected at 4.5 ml/s followed by 30 ml saline. The scan was initiated according to the bolus-tracking technique. Metoprolol (standard dosage: 5 mg) was intravenously administered before CTA with a titration dose in patients with heart rate > 70 bpm. Prospective ECG-triggered reconstruction was favored over retrospective ECG-gated reconstruction using automated best cardiac phase algorithms whenever a stable and low heart rate was available (heart beat variability < 15 bpm during breath-hold exam). Coronary arteries were divided into 15 segments according to the American Heart Association classification . Moderate and severe stenoses were judged as significant stenosis (> 50% lumen diameter) and considered as obstructive.
CS and CTA
All scans were performed in supine position in mid-inspiration breath-hold. The reconstructed CT image data were transferred to the computer workstation for post-processing. All analyses were performed by a single experienced reader (FB) using a Vitrea® workstation (Toshiba Medical Systems, Tokyo, Japan).
The decision for or against further invasive regimen was made by clinical decision pathways by the attending interventional cardiologist on the case. High CS > 400 or obstruction in the CTA favored coronary angiography during index stay. Because of the retrospective character, the decision to initiate invasive diagnostics was independent from the current analysis.
Descriptive data are reported as median and interquartile range (IQR) for continuous variables and count and percentage for categorical variables. The Wilcoxon rank sum test was used to compare continuous variables. Categorical variables were analyzed using Fisher’s exact test or Kruskal–Wallis rank sum test. The significance level was set at p = 0.05 and two-sided tests were used wherever possible. Tests were not corrected for multiple comparisons. Univariate odds ratios for predictors of significant coronary stenoses in coronary angiography were calculated using a logistic regression approach. Due to higher statistical power of percentile ranking, case–control matching was omitted. All statistical analyses were performed using the R Language and Environment for Statistical Computing, version 3.1.2 (R Foundation, Vienna, Austria).
Demographic and clinical data
A total of 618 patients were screened for study participation. 73 patients (59% female) patients fulfilled the inclusion criteria. Before CCT assessment, 24 patients or a proportion of 32% of the patients received treadmill testing first. In all of those cases, the results were judged as nondiagnostic during their index stay in the CPU. There was no additional noninvasive imaging (e.g., magnetic resonance imaging) other than transthoracic or transesophageal echocardiography. Median age did not differ significantly between female [73 (65–79) years] and male subjects [66 (56–74) years, p = 0.10]. Median heart rate at the time of CCT in sinus rhythm was 68 (59–74) bpm. Subjects with an Agatston score of 0 were significantly younger [62 (57–69) vs. 74 (66–79) years, p = 0.001] and tended to exhibit lower systolic blood pressure values than subjects with a score > 0 [125 (116–130) vs. 130 (125–150) mmHg, p = 0.061]. Baseline characteristics are summarized in Table 1. Typical symptoms at admission included atypical angina pectoris (100% by inclusion criteria), palpitations (78% in patients with an Agatston score of 0 vs. 82% otherwise, p = 0.74), dyspnea (33% vs. 62%, p = 0.055) and/or agitation (33% vs. 16%, p = 0.18) without any significant difference between those with and without CAC burden except for a trend to dyspnea in patients with coronary calcification. Further, there was no significant difference in conventional risk factors, left ventricular function or degree of mitral regurgitation with respect to presence or absence of CAC or relevant calcifying CAD as defined by an Agatston score > 75th percentile (Table 2). In addition, there was no significant difference for conventional risk factors between patients with compared to patients without relevant stenosis (Table 3). As displayed in Fig. 1, Agatston scores at admission were nonsignificantly higher in individuals with higher high sensitive- (hs-) troponin T values (all by definition not diagnostic for myocardial infarction, p = 0.8) . When plotting CS categories (0–400, 400–1000, > 1000) against hs-troponin T, the highest values were found in patients with no or minimal CS (p = 0.38). Whereas hs-troponin values tend to be higher in patients in the lower CS category, no cutoff hs-troponin T value can be defined excluding high CS.
CS: amount and distribution of CAC burden
Agatston scores ranged between 0 and 2726 with a median of 77 and an IQR of 1–270. When analyzed per territory, the highest Agatston scores were found in the LAD, and the median score in all other territories was 0 [LM: 0 (0–11); LAD: 44 (0–136), LCX: 0 (0–49); RCA: 0 (0–48), respectively]. Detailed data on gender-specific CAC burden per territory are given in Fig. 2 [scaled using the transformation f(x) = log(x + 1)]. In all territories, male subjects displayed higher Agatston scores. When comparing zero CS scores to positive CS scores, 23% of males (n = 7) and 25% of females (n = 11) had no CAC (Fig. 3). For those patients with positive CS scores, our study population shows a relative accordance to reference percentile distribution.
CTA: obstructive lesions
Computed tomography angiography was performed in 34 patients (51% of females, 60% of males). In two cases, we performed retrospective gating due to significant supraventricular extrasystole, the remaining underwent prospective gating. All CTAs were judged as diagnostic and 136 vessels and 357 segments were analyzed in total. Significant stenoses were found in four patients or 12% of the CTAs (male: n = 0, female: n = 4). Stenotic vessels comprised LAD (n = 2) or RCA (n = 2) only.
Decision for an invasive coronary angiogram: positive CTA versus high CS
A total of 16 subjects underwent invasive angiography. The decision to perform coronary catheterization is assumed to be made because of a positive CTA in 4 cases, and because of high CS in 12 cases. Invasive angiography revealed significant coronary artery stenosis in 5 subjects and only mild to intermediate stenosis in the remaining 11 subjects. Two individuals underwent percutaneous intervention (one patient with positive CTA, one patient with coronary angiography due to high CS), and in 3 cases an aortocoronary bypass graft placement was performed (one patient with positive CTA, and two patients with coronary angiography due to high CS). In half of the patients in whom the decision to perform coronary angiography was presumably made because of a positive CTA (n = 4), significant stenosis was confirmed by coronary angiography. In those subjects with an invasive regimen, median Agatston scores were high [1041 (374–1232)] with the highest values in the LAD [394 (223–660)]. Patients with revascularization exhibited higher CS within the LM territory [83 (67–97)] compared to those without [11 (2–38)]. On univariate analysis, relevant CS, defined as an Agatston above average (> 50th percentile), did not serve as an independent predictor for coronary stenosis during coronary angiography (odds ratio: 1.47, confidence interval 0.71–3.03; p = 0.32).
According to CPU registry data, CCT is not commonly used in German CPUs. Only about 5% of all-comers received CCT following admittance to a CPU, mostly as a rule-out approach in the majority of cases. Importantly, however, even this small number of patients receiving CCT helped to prevent unnecessary invasive catheterization procedures, since patients with CCT underwent significantly less often coronary angiography or revascularization . Nonetheless, target CPU subsets have to be identified that may profit most from noninvasive imaging procedures. It has been shown that CCT allows to accurately rule out coronary stenoses in patients with an intermediate pretest likelihood for CAD . Our current study was conducted to evaluate the impact of CCT for patients presenting to the CPU with symptomatic, non-ACS, new-onset AF and an intermediate pretest probability for CAD. The main findings are: (i) CAD could be virtually excluded in 25% of all patients by zero CS, (ii) CS scores above the median were present in about 50%, reflecting a good accordance between the study and the reference percentile distribution, (iii) 22% of all patients could be stratified as “at risk” due to a positive CTA or high (CS > 400) or very high (CS > 1000) CAC burden, and (iv) 7% of the cohort subjects underwent a coronary intervention, suggesting a potential role of AF as trigger of ischemia. Thus, the use of additional CCT during CPU work-up was able to identify relevant atherosclerotic comorbidity in up to one quarter of the patients as compared to standard work-up. Nonetheless, relevant CS, defined as an Agatston above the median (> 50th percentile), was not a predictor for coronary stenosis during coronary angiography in our study population; this effect could have been caused by small sample size, however.
Although sample size was too small for statistical subgroup analyses, median CS scores tended to be higher in males. These gender-specific scores were comparable to those found in AF subjects with known cardiovascular disease or treated risk factors in the unselected general population of the Heinz Nixdorf Recall study. In their study, Möhlenkamp et al.  evaluated the association of CAC burden assessed by CCT with resting ECG abnormalities. Keeping in mind that their study population was nearly devoid of subjects with AF and known cardiovascular disease or treated risk factors, they found that a CAC score > 75th percentile was more prevalent in AF subjects. These results are in conflict with ours, which show a good accordance between the percentiles of our study population and the reference percentile distribution resulting from the Heinz Nixdorf Recall study. Previous literature focusing on the relationship between atrial tissue ischemia, CAD and the coronary artery tree remains inconsistent [19,20,21]. In our study, we found the highest overall Agatston scores in the LAD in patients undergoing coronary intervention/revascularization, and calcification of the LM was more often present in patients with significant stenosis. Different as expected and in line with previous results, elevated hs-troponin levels neither exhibited a certain cutoff level to discriminate between those with low or high calcium burden, nor served as a marker for identifying patients at risk as the highest amounts were even found within the zero CS or low CS groups, together arguing against the hypothesis of a lower ischemic tolerance in high CS patients in our subset .
High (> 400) or very high (> 1000) CS scores were present in nearly a quarter of the study population, which appears to be higher than those anticipated and higher than those previously reported within a population-based approach . Of note, one of the conventional risk factors was able to significantly differentiate between those with and without relevant calcification, and conventional risk factors also failed to distinguish between those with and without relevant stenosis. In our study, we found that 12 out of 73 patients received coronary angiography due to high CS. Of those, three patients (equaling 25%) needed coronary intervention. However, as the study was designed as a retrospective observational study, we do not have invasive controls of CCT findings by coronary angiography as gold standard. Therefore, the definite role of different amounts of coronary calcification remains open. On the other hand, up to the current literature, CTA is supposed to be more sensitive than any other available noninvasive imaging technique, while the recommendation in patients with low-to-intermediate pretest probability for CAD stems from a high negative predictive value (99–100%) [24, 25]. In our study, additional CTA was performed in 47% of all patients and judged positive in 12%. Even though the positive predictive value of CCT/CTA was limited, as much as one-third of patients triaged to further invasive diagnostics following CCT displayed relevant stenosis afterward. This percentage is unexpectedly high compared with the current data from a CPU registry, demonstrating a low rate of coronary intervention in “real” troponin-negative ACS patients even including high-risk patients of 18%, although only about 7% exhibited AF at admission . Keeping in mind that all patients were triaged as non-ACS patients at the time of admission by the CPU physician and, therefore, that the study cohort mainly consisted of non-target CPU patients, CCT is thought to add crucial diagnostic information in the diagnostic work-flow even in patients presenting with atypical chest pain, the first diagnosed AF, and intermediate pretest probability for CAD admitted to a CPU for their atypical symptoms, yet on-top of the main CPU subset presenting with typical ACS. Whether we were able to visualize only subclinical atherosclerosis or whether CCT was able to detect CAD as an ischemic trigger of the new-onset AF remains speculative. However, we anticipate that using standard protocols, most of the patients declared as at risk following CCT would have been simply discharged following cardioversion and might have returned shortly after as “real” CPU patients with coronary event.
Besides those “positive” patients, 25% of our patients had CS of zero. The diagnostic value of zero CS within patients presenting with acute chest pain to the emergency department has been previously discussed [27,28,29]. In summary, the prevalence of significant CAD seems to be low and the negative predictive value high. Even though, because of the design of our study, coronary angiography was not performed as a gold standard in patients with zero CS and thus validation is biased, based on the available studies, we still propose that a CS of zero may also be used as a gatekeeper prior to further diagnostic steps in our commonly encountered subgroup.
In addition to the designated diagnostic value of CCT to prevent unnecessary invasive catheterization procedures, thus avoiding risk to the patient and saving costs in the healthcare system, as well as the value to indicate those with a high risk of obstructive CAD, there still remained slightly more than a half within the “gray zone” of low-to-average CAC burden or high CAC burden but nonobstructive CAD. But even in this part of the population, patients may benefit from atherosclerotic disease quantification in terms of more intense risk factor modification [8, 30]. On the other hand, ruling out relevant CAD may also be helpful in choosing potential drugs for antiarrhythmic therapy, particularly when the use of class I antiarrhythmic drugs, such as flecainide, is considered .
This study is a retrospective, single-center, observational project on a small cohort with inherent limitations and may be underpowered due to the small sample size. In this respect, the study lacks comparison to results of CCT in a control group of patients with atypical chest pain and an intermediate pretest probability but without AF admitted to CPU. Small sample size forced a descriptive approach in some subgroup analyses. Exclusion of patients with relevant kidney failure causes a systematic bias of patients at risk for CAD, additionally—even though by clinical pathways, all patients with the new-onset AF and atypical chest pain and low-to-intermediate pretest probability should be included—a certain selection bias by retrospectively analyzing CCT data only cannot be completely excluded. The fact that only subjects with high CS or obstruction in CTA underwent coronary angiography represents a major bias. This means that CAD could not be completely ruled out in the low CS and nonobstructive CTA group. However, the decision for invasive angiography was made by the cardiac interventionalist on the case based on clinical decision pathways, and not by randomization. In addition, we are aware of the fact that a zero CS alone cannot completely rule out CAD, but is only associated with a very low probability and good prognosis . Based on our inclusion criteria, our cohort merely consisted of patients with the new-onset AF with image acquisition following cardioversion. Thus, our findings cannot be transferred to other AF forms, especially permanent AF. Nonetheless, according to analyses using new generation scanner, it appears feasible to extensive use and scientific efforts to these groups, too [33, 34]. Not the least, controversies with regard to the recent PROMISE data on nonsuperiority of CCT against functional stress testing showing higher rates of coronary revascularization following CCT without benefit during long-term outcome have to be considered .
In our study population, CCT was able to virtually exclude relevant CAD in about one quarter and detect relevant CAD in about another quarter of the subjects, putting those patients on a higher risk level and accelerating standard diagnostics. As much as 31% of those patients declared as at risk equaling 7% of the total study population needed coronary intervention. For the rest, analysis of CAC burden may be useful to guide risk factor modification efforts or to aid in the choice of a drug class for antiarrhythmic therapy. Thus, our data underline the benefit of CCT within the CPU concept at least in this selected but commonly encountered non-target CPU patient population by having a strong impact on patients’ management in terms of improved risk stratification, risk factor modulation, and selection for additional interventional diagnostics. Nevertheless, as in our small cohort CAC burden exceeding the 50th percentile statistically has not been proven to be an independent predictor of coronary stenosis, our suggestion should be evaluated in larger studies on a prospective and case-controlled basis.
coronary artery calcification
coronary artery disease
cardiac computed tomography
chest pain unit
computed tomography angiography
Heinz Nixdorf Recall
high sensitive troponin
left anterior descendent
left circumflex artery
right coronary artery
Breuckmann F, Burt DR, Melching K, Erbel R, Heusch G, Senges J, Garvey JL. Chest pain centers: a comparison of accreditation programs in Germany and the United States. Crit Pathw Cardiol. 2015;14(2):67–73.
Illmann A, Riemer T, Erbel R, Giannitsis E, Hamm C, Haude M, Heusch G, Maier LS, Münzel T, Schmitt C, Schumacher B, Senges J, Voigtländer T, Mudra H. Disease distribution and outcome in troponin-positive patients with or without revascularization in a chest pain unit: results of the German CPU-Registry. Clin Res Cardiol. 2014;103(1):29–40.
Schmitt J, Duray G, Gersh BJ, Hohnloser SH. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30(9):1038–45.
Brown AM, Sease KL, Robey JL, Shofer FS, Hollander JE. The risk for acute coronary syndrome associated with atrial fibrillation among ED patients with chest pain syndromes. Am J Emerg Med. 2007;25(5):523–8.
Taylor AJ, Cerqueira M, Hodgson JM, Mark D, Min J, O’Gara P, Rubin GD. ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance. American College of Cardiology Foundation Appropriate Use Criteria Task Force; Society of Cardiovascular Computed Tomography; American College of Radiology; American Heart Association; American Society of Echocardiography; American Society of Nuclear Cardiology; North American Society for Cardiovascular Imaging; Society for Cardiovascular Angiography and Interventions; Society for Cardiovascular Magnetic Resonance. Circulation. 2010;122(21):e525–55.
Hecht HS. Coronary artery calcium scanning: past, present, and future. JACC Cardiovasc Imaging. 2015;8(5):579–96.
Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano RJ. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15(4):827–32.
Oudkerk M, Stillman AE, Halliburton SS, Kalender WA, Möhlenkamp S, McCollough CH, Vliegenthart R, Shaw LJ, Stanford W, Taylor AJ, van Ooijen PM, Wexler L, Raggi P. Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging. European Society of Cardiac Radiology; North American Society for Cardiovascular Imaging. Eur Radiol. 2008;18(12):2785–807.
Breuckmann F, Hochadel M, Voigtländer T, Haude M, Schmitt C, Münzel T, Giannitsis E, Mudra H, Heusch G, Schumacher B, Barth S, Schuler G, Hailer B, Walther D, Senges J. Cardiac computed tomography in certified German chest pain units. Crit Pathw Cardiol. 2016;15(1):11–5.
Post F, Gori T, Giannitsis E, Darius H, Baldus S, Hamm C, Hambrecht R, Hofmeister HM, Katus H, Perings S, Senges J, Münzel T. Criteria of the German Society of Cardiology for the establishment of chest pain units: update 2014. Clin Res Cardiol. 2015;104(11):918–28.
Genders TS, Steyerberg EW, Alkadhi H, Leschka S, Desbiolles L, Nieman K, Galema TW, Meijboom WB, Mollet NR, de Feyter PJ, Cademartiri F, Maffei E, Dewey M, Zimmermann E, Laule M, Pugliese F, Barbagallo R, Sinitsyn V, Bogaert J, Goetschalckx K, Schoepf UJ, Rowe GW, Schuijf JD, Bax JJ, de Graaf FR, Knuuti J, Kajander S, van Mieghem CA, Meijs MF, Cramer MJ, Gopalan D, Feuchtner G, Friedrich G, Krestin GP, Hunink MG, CAD Consortium. A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension. Eur Heart J. 2011;32(11):1316–30.
Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, Heidbuchel H, Alfieri O, Angelini A, Atar D, Colonna P, De Caterina R, De Sutter J, Goette A, Gorenek B, Heldal M, Hohloser SH, Kolh P, Le Heuzey JY, Ponikowski P, Rutten FH. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery. Eur Heart J. 2010;31(19):2369–429.
Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, Hindricks G, Kirchhof P. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. ESC Committee for Practice Guidelines-CPG; Document Reviewers. Europace. 2012;14(10):1385–413.
Erbel R, Lehmann N, Churzidse S, Rauwolf M, Mahabadi AA, Möhlenkamp S, Moebus S, Bauer M, Kälsch H, Budde T, Montag M, Schmermund A, Stang A, Führer-Sakel D, Weimar C, Roggenbuck U, Dragano N, Jöckel KH, Heinz Nixdorf Recall Study Investigators. Progression of coronary artery calcification seems to be inevitable, but predictable—results of the Heinz Nixdorf Recall (HNR) study. Eur Heart J. 2014;35(42):2960–71.
Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, McGoon DC, Murphy ML, Roe BB. A reporting system on patients evaluated for coronary artery disease: report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation. 1975;51(4 Suppl):5–40.
Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, Ohman M, Petrie MC, Sonntag F, Uva MS, Storey RF, Wijns W, Zahger D, ESC Committee for Practice Guidelines. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011;32(23):2999–3054.
Leber AW, Johnson T, Becker A, von Ziegler F, Tittus J, Nikolaou K, Reiser M, Steinbeck G, Becker CR, Knez A. Diagnostic accuracy of dual-source multi-slice CT-coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease. Eur Heart J. 2007;28(19):2354–60.
Möhlenkamp S, Schmermund A, Lehmann N, Roggenbuck U, Dragano N, Stang A, Moebus S, Beck EM, Schlüter C, Sack S, Meinertz T, Taylor A, Jöckel KH, Erbel R, Heinz Nixdorf Recall Study Investigators. Subclinical coronary atherosclerosis and resting ECG abnormalities in an unselected general population. Atherosclerosis. 2008;196(2):786–94.
Alasady M, Abhayaratna WP, Leong DP, Lim HS, Abed HS, Brooks AG, Mattchoss S, Roberts-Thomson KC, Worthley MI, Chew DP, Sanders P. Coronary artery disease affecting the atrial branches is an independent determinant of atrial fibrillation after myocardial infarction. Heart Rhythm. 2011;8(7):955–60.
Kyriakidis M, Barbetseas J, Antonopoulos A, Skouros C, Tentolouris C, Toutouzas P. Early atrial arrhythmias in acute myocardial infarction: role of the sinus node artery. Chest. 1992;101(4):944–7.
Tjandrawidjaja MC, Fu Y, Kim DH, Burton JR, Lindholm L, Armstrong PW, CAPTORS II Investigators. Compromised atrial coronary anatomy is associated with atrial arrhythmias and atrioventricular block complicating acute myocardial infarction. J Electrocardiol. 2005;38(3):271–8.
Filion KB, Agarwal SK, Ballantyne CM, Eberg M, Hoogeveen RC, Huxley RR, Loehr LR, Nambi V, Soliman EZ, Alonso A. High-sensitivity cardiac troponin T and the risk of incident atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J. 2015;169(1):31.e3–38.e3.
Schmermund A, Möhlenkamp S, Berenbein S, Pump H, Moebus S, Roggenbuck U, Stang A, Seibel R, Grönemeyer D, Jöckel KH, Erbel R. Population-based assessment of subclinical coronary atherosclerosis using electron-beam computed tomography. Atherosclerosis. 2006;185(1):177–82.
Yang L, Zhou T, Zhang R, Xu L, Peng Z, Ding J, Wang S, Li M, Sun G. Meta-analysis: diagnostic accuracy of coronary CT angiography with prospective ECG gating based on step-and-shoot, Flash and volume modes for detection of coronary artery disease. Eur Radiol. 2014;24(10):2345–52.
Task Force Members, Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Sabaté M, Senior R, Taggart DP, van der Wall EE, Vrints CJ, ESC Committee for Practice Guidelines, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Document Reviewers, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Knuuti J, Valgimigli M, Bueno H, Claeys MJ, Donner-Banzhoff N, Erol C, Frank H, Funck-Brentano C, Gaemperli O, Gonzalez-Juanatey JR, Hamilos M, Hasdai D, Husted S, James SK, Kervinen K, Kolh P, Kristensen SD, Lancellotti P, Maggioni AP, Piepoli MF, Pries AR, Romeo F, Rydén L, Simoons ML, Sirnes PA, Steg PG, Timmis A, Wijns W, Windecker S, Yildirir A, Zamorano JL. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34(38):2949–3003.
Maier LS, Darius H, Giannitsis E, Erbel R, Haude M, Hamm C, Hasenfuss G, Heusch G, Mudra H, Münzel T, Schmitt C, Schumacher B, Senges J, Voigtländer T, Schüttert JB. The German CPU Registry: comparison of troponin positive to troponin negative patients. Int J Cardiol. 2013;168(2):1651–3.
Andrews TC. Electron-beam computed tomography in the evaluation of patients with chest pain. Am J Cardiol. 2000;85(3):386–7.
Stillman AE, Oudkerk M, Ackerman M, Becker CR, Buszman PE, de Feyter PJ, Hoffmann U, Keadey MT, Marano R, Lipton MJ, Raff GL, Reddy GP, Rees MR, Rubin GD, Schoepf UJ, Tarulli G, van Beek EJ, Wexler L, White CS. Use of multidetector computed tomography for the assessment of acute chest pain: a consensus statement of the North American Society of Cardiac Imaging and the European Society of Cardiac Radiology. Eur Radiol. 2007;17(8):2196–207.
Vogler N, Meyer M, Fink C, Schoepf UJ, Schönberg SO, Henzler T. Predictive value of zero calcium score and low-end percentiles for the presence of significant coronary artery stenosis in stable patients with suspected coronary artery disease. Rofo. 2013;185(8):726–32.
Erbel R, Möhlenkamp S, Lehmann N, Schmermund A, Moebus S, Stang A, Grönemeyer D, Seibel R, Mann K, Volbracht L, Dragano N, Siegrist J, Jöckel KH, Heinz Nixdorf Recall Study Investigative Group. Sex related cardiovascular risk stratification based on quantification of atherosclerosis and inflammation. Atherosclerosis. 2008;197(2):662–72.
Aliot E, Capucci A, Crijns HJ, Goette A, Tamargo J. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011;13(2):161–73.
Dedic A, Ten Kate GJ, Neefjes LA, Rossi A, Dharampal A, Rood PP, Galema TW, Schultz C, Ouhlous M, Moelker A, de Feyter PJ, Nieman K. Coronary CT angiography outperforms calcium imaging in the triage of acute coronary syndrome. Int J Cardiol. 2013;167(4):1597–602.
Vorre MM, Abdulla J. Diagnostic accuracy and radiation dose of CT coronary angiography in atrial fibrillation: systematic review and meta-analysis. Radiology. 2013;267(2):376–86.
Di Cesare E, Gennarelli A, Di Sibio A, Felli V, Splendiani A, Gravina GL, Masciocchi C. Image quality and radiation dose of single heartbeat 640-slice coronary CT angiography: a comparison between patients with chronic atrial fibrillation and subjects in normal sinus rhythm by propensity analysis. Eur J Radiol. 2015;84(4):631–6.
Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B, Cole J, Dolor RJ, Fordyce CB, Huang M, Khan MA, Kosinski AS, Krucoff MW, Malhotra V, Picard MH, Udelson JE, Velazquez EJ, Yow E, Cooper LS, Lee KL, PROMISE Investigators. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;372(14):1291–300.
MK, LH, and FB planned and developed the project, evaluated the results, and wrote the manuscript. LH and JO collected and analyzed the data. ML, DB, LE, and JW edited the manuscript. All authors read and approved the final manuscript.
Matthias Koopmann is supported by the German Heart Foundation (Deutsche Herzstiftung e.V.). This work is part of the doctoral thesis of Liane Hinrichs.
The authors declare that they have no competing interests.
Availability of data and materials
The reported data are stored and secured on the PACS of the Department of Cardiology, Arnsberg Medical Center, Arnsberg, Germany.
Consent for publication
Ethics approval and consent to participate
The aforementioned protocol was reviewed by the local Ethics Committee (Ärztekammer Westfalen-Lippe and the University of Münster, Germany; AZ2014-651). Given that we only used anonymized clinical routine data from the patients’ hospital records without additional examinations, informed consent by the patients is not required according to § 6 (2) “Gesundheitsdatenschutzgesetz” (health data protection act) North Rhine-Westphalia, Germany. Therefore, the Ethics Committee considers the application and issue of an ethical approval as not necessary.
This study was not supported by external funding.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Koopmann, M., Hinrichs, L., Olligs, J. et al. Cardiac computed tomography in patients with symptomatic new-onset atrial fibrillation, rule-out acute coronary syndrome, but with intermediate pretest probability for coronary artery disease admitted to a chest pain unit. Eur J Med Res 23, 6 (2018). https://doi.org/10.1186/s40001-018-0303-3
- Cardiac computed tomography
- Atrial fibrillation
- Coronary artery disease
- Chest pain unit
- Intermediate pretest probability