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Table 6 Mean reduction effects on hemostasis parameters after sonication (n = 5) using additional CO2-shielding in relation to ultrasound frequency and duration (percentage reduction in comparison to untreated blood samples)

From: Novel method for reduction of virus load in blood plasma by sonication

Sonication treatments using CO2-shielding (+CO2; +US) for hemostasis investigations
 Frequency (kHz)27423370250
 Power density (W/cm2)1.601.600.480.530.48
 Duration (min)180300180300180300180300180300
Mean reduction of various hemostasis markers (%)
 Quick10 (± 1)24 (± 2)9 (± 1)24 (± 2)5 (± 1)7 (± 1)2 (± 1)3 (± 1)9 (± 1)17 (± 2)
 aPTT11 (± 1)26 (± 3)14 (± 2)29 (± 3)2 (± 1)6 (± 1)1 (± 1)1 (± 1)15 (± 1)26 (± 2)
 Fibrinogen30 (± 2)35 (± 4)32 (± 3)38 (± 2)27 (± 1)32 (± 2)21 (± 2)28 (± 2)29 (± 3)36 (± 2)
 FIX0 (± 0)0 (± 0)0 (± 0)0 (± 0)0 (± 0)0 (± 0)0 (± 0)0 (± 0)5 (± 3)6 (± 3)
 FVIII51 (± 5)61 (± 6)48 (± 5)53 (± 5)52 (± 4)55 (± 5)28 (± 4)33 (± 4)68 (± 6)75 (± 5)