Table 6 Mean reduction effects on hemostasis parameters after sonication (n = 5) using additional CO2-shielding in relation to ultrasound frequency and duration (percentage reduction in comparison to untreated blood samples)
From: Novel method for reduction of virus load in blood plasma by sonication
Sonication treatments using CO2-shielding (+CO2; +US) for hemostasis investigations | ||||||||||
Frequency (kHz) | 27 | 42 | 33 | 70 | 250 | |||||
Power density (W/cm2) | 1.60 | 1.60 | 0.48 | 0.53 | 0.48 | |||||
Duration (min) | 180 | 300 | 180 | 300 | 180 | 300 | 180 | 300 | 180 | 300 |
Mean reduction of various hemostasis markers (%) | ||||||||||
Quick | 10 (± 1) | 24 (± 2) | 9 (± 1) | 24 (± 2) | 5 (± 1) | 7 (± 1) | 2 (± 1) | 3 (± 1) | 9 (± 1) | 17 (± 2) |
aPTT | 11 (± 1) | 26 (± 3) | 14 (± 2) | 29 (± 3) | 2 (± 1) | 6 (± 1) | 1 (± 1) | 1 (± 1) | 15 (± 1) | 26 (± 2) |
Fibrinogen | 30 (± 2) | 35 (± 4) | 32 (± 3) | 38 (± 2) | 27 (± 1) | 32 (± 2) | 21 (± 2) | 28 (± 2) | 29 (± 3) | 36 (± 2) |
FIX | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 5 (± 3) | 6 (± 3) |
FVIII | 51 (± 5) | 61 (± 6) | 48 (± 5) | 53 (± 5) | 52 (± 4) | 55 (± 5) | 28 (± 4) | 33 (± 4) | 68 (± 6) | 75 (± 5) |