Table 1 Mendelian randomization (MR) estimates for the relationship between genetically instrumented broad obesity, BMI, BF%, WC and facial aging
From: Association between adiposity and facial aging: results from a Mendelian randomization study
Exposure | Method | Outcome: facial aging (P < 5 × 10–4) | ||
|---|---|---|---|---|
OR | 95%CI | p-value | ||
Broad obesity | Inverse variance weighted | 1.020 | 1.010, 1.029 | 7.303e-05 |
MR-Egger regression | 1.037 | 1.009, 1.065 | 1.872e-02 | |
Weighted median | 1.024 | 1.016, 1.032 | 4.661e-09 | |
Simple mode | 1.023 | 1.010, 1.037 | 3.131e-03 | |
Weighted mode | 1.023 | 1.014, 1.032 | 1.722e-04 | |
BMI | Inverse variance weighted | 1.047 | 1.036, 1.058 | 1.154e-16 |
MR-Egger regression | 1.057 | 1.026, 1.088 | 2.626e-04 | |
Weighted median | 1.055 | 1.043, 1.068 | 6.407e-20 | |
Simple mode | 1.034 | 0.990, 1.080 | 1.407e-01 | |
Weighted mode | 1.063 | 1.037, 1.089 | 1.437e-06 | |
BF % | Inverse variance weighted | 1.056 | 1.040, 1.072 | 7.617e-12 |
MR-Egger regression | 1.071 | 1.019, 1.126 | 7.679e-03 | |
Weighted median | 1.066 | 1.048, 1.083 | 9.156e-15 | |
Simple mode | 1.065 | 1.006, 1.127 | 3.017e-02 | |
Weighted mode | 1.078 | 1.030, 1.128 | 1.385e-03 | |
WC | Inverse variance weighted | 1.072 | 1.057, 1.087 | 1.229e-23 |
MR-Egger regression | 1.072 | 1.031, 1.115 | 4.842e-04 | |
Weighted median | 1.065 | 1.049, 1.081 | 5.379e-16 | |
Simple mode | 1.059 | 1.007, 1.113 | 2.529e-02 | |
Weighted mode | 1.065 | 1.036, 1.096 | 1.059e-05 | |