Fig. 7

Latent molecular mechanisms of the critical genes in T2DM progression. A GO term for CDKN1C gene set enrichment analysis (GSEA). B KEGG term of gene set enrichment analysis (GSEA) for CDKN1C. C GO term for DLK1 gene set enrichment analysis (GSEA). D KEGG term of DLK1 gene set enrichment analysis (GSEA). The top portion of the plot shows the running enrichment score (ES) for the gene set as the analysis walks down the ranked list. The score at the peak of the plot is the ES for the gene set. The middle portion of the plot shows where the members of the gene set appear in the ranked list of genes. For a positive ES, the leading edge subset is the set of members that appear in the ranked list prior to the peak score. For a negative ES, it is the set of members that appear subsequent to the peak score. The bottom portion of the plot shows the value of the ranking metric when the list of ranked genes is moved down, measuring the correlation of gene with a phenotype and sorted using Signal2noise