Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. Coronavirus investigating, and research team a novel coronavirus from patients with pneumonia in China 2019. N Engl J Med. 2020;382(8):727–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Organization WH. Coronavirus disease (COVID-19) pandemic–emergency use listing procedure (EUL) open for in vitro diagnostics. 2020-02-28) [2020-05-21]. https://www.who.int/diagnostics_laboratory/EUL/en. 2020
Batiha GES, Gari A, Elshony N, Shaheen HM, Abubakar MB, Adeyemi SB, et al. Hypertension and its management in COVID-19 patients The assorted view. Int J Cardiol Cardiovasc Risk Prev. 2021;11:200121. https://doi.org/10.1016/j.ijcrp.2021.200121.
Article
PubMed
PubMed Central
Google Scholar
Gammone MA, D’Orazio N. COVID-19 and obesity: overlapping of two pandemics. Obes Facts. 2021;14(6):579–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
GhaffariDarab M, Keshavarz K, Sadeghi E, Shahmohamadi J, Kavosi Z. The economic burden of coronavirus disease 2019 (COVID-19): evidence from Iran. BMC Health Serv Res. 2021;21(1):1–7.
Google Scholar
Kuba K, Yamaguchi T, Penninger JM. Angiotensin-converting enzyme 2 (ACE2) in the pathogenesis of ARDS in COVID-19. Front Immunol. 2021;12:1–7.
Article
Google Scholar
Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem. 2000;74(1):34–41.
Article
CAS
PubMed
Google Scholar
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002;277(17):14838–43.
Article
CAS
PubMed
Google Scholar
Li L, Xu J, Chen L, Jiang Z. Apelin/APJ system a novel promising therapy target for thrombotic diseases. Clin Chim Acta. 2016;48(April):589–91.
CAS
Google Scholar
Yan J, Wang A, Cao J, Chen L. Apelin/APJ system: an emerging therapeutic target for respiratory diseases. Cell Mol Life Sci. 2020;77(12):2919.
Article
CAS
PubMed
Google Scholar
Liu W, Yan J, Pan W, Tang M. Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system. Ann Transl Med. 2020;8(5):243.
Article
CAS
PubMed
PubMed Central
Google Scholar
Habchi M, Duvillard L, Cottet V, Brindisi MC, Bouillet B, Beacco M, et al. Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control. Clin Endocrinol (Oxf). 2014;81(5):696–701.
Article
CAS
Google Scholar
Bellissimo MP, Hsu E, Hao L, Easley K, Martin GS, Ziegler TR, et al. Relationships between plasma apelin and adiponectin with normal weight obesity, body composition, and cardiorespiratory fitness in working adults. J Clin Transl Endocrinol. 2021;24:100257.
CAS
PubMed
PubMed Central
Google Scholar
Noyan T, Figen CC, Özdemir Ö. The investigation effect of weight loss on serum vaspin, apelin-13, and obestatin levels in obese individual. Turkish J Biochem. 2020;45(6):725–35.
Article
Google Scholar
Wysocka MB, Pietraszek-gremplewicz K, Nowak D. The role of apelin in cardiovascular diseases. Obesity and Cancer. 2018;9(May):1–15.
Google Scholar
Xie H, Luo G, Zheng Y, Hu D, Peng F, Xie L. Lowered circulating apelin is significantly associated with an increased risk for hypertension a meta-analysis. Clin Exp Hypertens. 2017;00(00):1–6. https://doi.org/10.1080/10641963.2016.1267199.
Article
CAS
Google Scholar
Xie L, Zhang Z, Wang Q, Chen Y, Lu D, Wu W. COVID-19 and diabetes: a comprehensive review of angiotensin converting enzyme 2 mutual effects and pharmacotherapy. Front Endocrinol. 2021;12(November):1–25.
CAS
Google Scholar
Khatib A, Lopez JJ, Vatier C, Turpin S, Muscat A, Soulet F, et al. Apelin an antithrombotic factor that inhibits platelet function. Journal Am Soc Hematol. 2016;127(7):908–20.
Google Scholar
Kalea AZ, Batlle D. Apelin and ACE2 in cardiovascular disease. Curr Opin Investig Drugs. 2014;11(3):273.
Google Scholar
Najafipour H, Mirzazadeh A, Haghdoost AA, Shadkam M, Afshari M, Moazenzadeh M, et al. Coronary artery disease risk factors in an urban and peri-urban setting, Kerman, Southeastern Iran (KERCADR study): methodology and preliminary report. Iran J Public Health. 2012;41(9):86.
CAS
PubMed
PubMed Central
Google Scholar
Bonow RO, Mann DL, Zipes DP, Libby P. Braunwald’s heart disease-book: a textbook of cardiovascular medicine. Amsterdam: Elsevier Health Sciences; 2011.
Google Scholar
Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison’s principles of internal medicine. New York: Mcgraw-hill; 2012.
Google Scholar
Organization WH. Global database on Body Mass Index: BMI Classification. 2006. World Heal Organ Geneva, Switz. 2015
He X, Liu C, Peng J, Li Z, Li F, Wang J, et al. COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors. Signal Transduct Target Ther. 2021;6(1):427.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liakos CI, Sanidas EA, Perrea DN, Grassos CA, Chantziara V, Viniou N-A, et al. Apelin and visfatin plasma levels in healthy individuals with high normal blood pressure. Am J Hypertens. 2016;29(5):549–52.
Article
CAS
PubMed
Google Scholar
Yucel AA, Gulen S, Dincer S, Yucel AE, Yetkin GI. Comparison of two different applications of the griess method for nitric oxide measurement. J Exp Integr Med. 2012;2:1.
Article
Google Scholar
Li X-T, Zhang M-W, Zhang Z-Z, Cao Y-D, Liu X-Y, Miao R, et al. Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19. Int J Cardiol. 2021;336:123–9.
Article
PubMed
PubMed Central
Google Scholar
Sabry MM, Mahmoud MM, Shoukry HS, Rashed L, Kamar SS, Ahmed MM. Interactive effects of apelin, renin–angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats. Arch Physiol Biochem. 2019;125(3):244–54.
Article
CAS
PubMed
Google Scholar
Physiology C. Apelin-13 administration protects against LPS-induced acute lung injury by inhibiting NF-κB pathway and NLRP3 inflammasome activation. Cell Physiol Biochem. 2018;49:1918–32.
Article
Google Scholar
Reindl-Schwaighofer R, Hödlmoser S, Eskandary F, Poglitsch M, Bonderman D, Strassl R, et al. ACE2 elevation in severe COVID-19. Am J Respir Crit Care Med. 2021;203(9):1191–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, et al. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 2017;113(7):760–9.
Article
CAS
PubMed
Google Scholar
Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J-C, Turner AJ, et al. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ Res. 2020;126(10):1456–74.
Article
CAS
PubMed
Google Scholar
Mehta N, Kalra A, Nowacki AS, Anjewierden S, Han Z, Bhat P, et al. Association of use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with testing positive for coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(9):1020–6.
Article
PubMed
Google Scholar
Heinonen I, Vuolteenaho O, Koskenvuo J, Arjamaa O, Nikinmaa M. Systemic hypoxia increases circulating concentration of apelin in humans. High Alt Med Biol. 2017;18(3):292–5.
Article
CAS
PubMed
Google Scholar
Alipour FG, Ashoori MR, Pilehvar-Soltanahmadi Y, Zarghami N. An overview on biological functions and emerging therapeutic roles of apelin in diabetes mellitus. Diabetes Metab Syndr Clin Res Rev. 2017;11:S919–23.
Article
Google Scholar
Demeulemeester F, de Punder K, van Heijningen M, van Doesburg F. Obesity as a risk factor for severe covid-19 and complications a review. Cells. 2021;10(4):933.
Article
CAS
PubMed
PubMed Central
Google Scholar