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The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review

European Journal of Medical Research volume 29, Article number: 181 (2024) Cite this article

Abstract

Background

Metachromatic leukodystrophy (MLD; OMIM 250100 and 249900) is a rare lysosomal storage disease caused by deficient arylsulfatase A activity, leading to accumulation of sulfatides in the nervous system. This systematic literature review aimed to explore the effect of MLD on the lives of patients.

Methods

The Ovid platform was used to search Embase, MEDLINE, and the Cochrane Library for articles related to the natural history, clinical outcomes, and burden of illness of MLD; congress and hand searches were performed using ‘metachromatic leukodystrophy’ as a keyword. Of the 531 publications identified, 120 were included for data extraction following screening. A subset of findings from studies relating to MLD natural history and burden of illness (n = 108) are presented here.

Results

The mean age at symptom onset was generally 16–18 months for late-infantile MLD and 6–10 years for juvenile MLD. Age at diagnosis and time to diagnosis varied widely. Typically, patients with late-infantile MLD presented predominantly with motor symptoms and developmental delay; patients with juvenile MLD presented with motor, cognitive, and behavioral symptoms; and patients with adult MLD presented with cognitive symptoms and psychiatric and mood disorders. Patients with late-infantile MLD had more rapid decline of motor function over time and lower survival than patients with juvenile MLD. Commonly reported comorbidities/complications included ataxia, epilepsy, gallbladder abnormalities, incontinence, neuropathy, and seizures.

Conclusions

Epidemiology of MLD by geographic regions, quantitative cognitive data, data on the differences between early- and late-juvenile MLD, and humanistic or economic outcomes were limited. Further studies on clinical, humanistic (i.e., quality of life), and economic outcomes are needed to help inform healthcare decisions for patients with MLD.

Background

Metachromatic leukodystrophy (MLD; OMIM 250100 and 249900) is a rare, life-limiting lysosomal storage disease (LSD). It is caused by pathogenic variants in the arylsulfatase A (ASA) or sphingolipid activator protein B (SAPB) genes (ARSA and PSAP, respectively), which are inherited in an autosomal recessive manner [1, 2]. Approximately 261 variants of ARSA and 64 variants of PSAP have been reported previously, and the majority of cases of MLD are associated with ASA deficiency [1, 2]. ASA or SAPB deficiency leads to accumulation of sulfatides throughout the body and is particularly detrimental to nervous system function [3]. The incidence (birth prevalence) of MLD varies across populations but has been estimated to be between 1 in 40,000 and 1 in 160,000 [1].

There are three clinical subtypes of MLD, based on the age at first symptom onset: late-infantile (onset ≤ 2.5 years), juvenile (onset 2.5– < 16 years), and adult (onset ≥ 16 years) MLD [4, 5]. Juvenile MLD has been further subdivided into early-juvenile and late-juvenile forms, which have onsets before or after the age of 6 years, respectively [5]. There is some evidence that disease onset with motor symptoms is associated with a more rapid disease progression than onset with cognitive symptoms only [5]. Patients with MLD are substantially impacted by a wide range of signs and symptoms, including gait abnormalities, speech regression, and seizures [1, 4]. Across all clinical subtypes of MLD, the lives of patients are shortened, with many patients not reaching adulthood [3, 4].

Published evidence about the natural history of MLD and how the disease affects the lives of patients is limited and has not, to our knowledge, been reviewed systematically.

For this systematic literature review (SLR), our aim was to understand how MLD affects the lives of patients. Here, we report a subset of our findings, focused on the epidemiology and natural history of MLD, including disease progression and associations between physical function and disease progression. While the focus of this SLR was on patients with late-infantile or juvenile MLD, relevant information from patients with adult MLD was also considered.

Methods

Search strategy

This study was conducted in accordance with guidelines from the Cochrane Collaboration [6], the University of York Centre for Reviews and Dissemination (CRD) [7], and the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) [8], and it was registered in the PROSPERO database.

The Ovid platform was used to search Embase (1974–2021), MEDLINE, and the Cochrane Library on June 23, 2021. The search strings used (Additional files 1, 2, 3) related to the natural history, clinical outcomes (not reported here), and burden of illness of MLD for patients with MLD. Congress and hand searches were also performed using ‘metachromatic leukodystrophy’ as a keyword. Congress searches covered the following congresses from 2020 to 2021: WORLDSymposium; International Congress of Inborn Errors of Metabolism; Society for the Study of Inborn Errors of Metabolism; International Society of Pharmacoeconomics and Outcomes Research European, US, and international congresses; Society for Inherited Metabolic Disorders; Child Neurology Society; American Neurological Association; European Society of Human Genetics; European Paediatric Neurology Society; European Academy of Neurology; American College of Medical Genetics and Genomics; European Society of Gene and Cell Therapy; and Congress of Neurological Surgeons. Hand searches covered the websites for ClinicalTrials.gov, the Cost-Effectiveness Analysis Registry, the International Clinical Trials Registry Platform, Research Papers in Economics, the University of Sheffield School of Health and Related Research Health Utilities Database, and the University of York CRD.

Eligibility criteria

The Participants, Interventions, Comparators, Outcomes, and Study design (PICOS) criteria are summarized in Table 1. For study titles and abstracts, double-blind screening was performed by two researchers, and any uncertainties were checked by a third reviewer. For congress abstracts and hand searches, screening was performed by one reviewer.

Table 1 PICOS eligibility criteria
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Full-text review and data extraction

Single-blind full-text review was performed by one reviewer, with a second person resolving any uncertainties to confirm eligibility. Data were extracted into a predefined data extraction table by one reviewer and independently checked for errors by a second reviewer. Discrepancies were resolved through discussion or with the intervention of a third reviewer. For papers that reported data across LSDs or on leukodystrophy cohorts, data were extracted for the patients with MLD only if outcomes were reported separately for these patients.

Quality assessment

No randomized controlled trials were identified, but quality assessment using the Risk Of Bias In Non-randomized Studies - of Interventions (ROBINS-I) tool was completed for all full publications reporting data from non-randomized interventional clinical studies. For publications reporting data from non-interventional studies, the overall quality of the evidence identified was informally assessed based on a review of study methods and population size.

Results

Search results

The search identified 531 publications, of which 63 were removed as duplicates before title/abstract screening and 267 were excluded following title/abstract screening (Fig. 1). The full texts of the remaining 201 publications were screened against the PICOS criteria, following which 111 published studies were considered eligible for inclusion. Six abstracts were also identified from the congress searches, and three studies were included on request. In total, data were extracted from 120 studies, of which 88 were full publications and 32 were abstracts. Of the 120 studies, 22 were interventional in design (all of which were single-armed) and the remaining 98 were observational. All non-randomized, interventional studies were assessed with the ROBINS-I tool and determined to be of moderate quality.

Fig. 1
figure 1

PRISMA diagram. aThe reference lists from these publications were cross-checked against lists of included references to ensure that all relevant data were identified. Data from SLRs/meta-analyses were not extracted. bFour references were data-extracted, but data were either not reported separately for patients with MLD, or no relevant data were reported in the publication. cOf the 120 publications from which data were extracted, 108 related to the natural history and burden of illness of MLD (i.e., non-treatment related). MLD: metachromatic leukodystrophy; PRISMA: Preferred Reporting Items for Systematic review and Meta-Analysis; SLR: systematic literature review

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The studies selected for data extraction used patient data from countries across six continents. The countries with the largest number of studies reporting patient data were the USA, Germany, and Italy (20, 12, and 12 studies, respectively). Six studies included data from multiple countries/continents, and the country was not reported or unclear for 13 studies. We report a subset of studies (n = 108) that describe the natural history and burden of illness of MLD. Of these, 70 were natural history studies. Note that any data from the remaining observational, retrospective, or interventional studies (n = 38) were related to patients who were not receiving treatment in the form of hematopoietic stem cell transplantation, gene therapy, or enzyme replacement therapy, except where otherwise stated.

Epidemiology

The birth incidence and birth prevalence of MLD were reported in eight [9,10,11,12,13,14,15,16] and four [13, 14, 16, 17] studies, respectively (Table 2). For birth incidence, only postnatal diagnoses were considered, whereas for birth prevalence, both prenatal and postnatal diagnoses were considered. The data from these studies spanned 10 countries over a wide time frame and used different methodologies.

The Czech Republic was reported to have the lowest birth prevalence of MLD at 0.69 per 100,000 births [16], and Poland was reported as having the highest birth prevalence of 4.1 per 100,000 births [13]. Sweden was reported to have the highest incidence of MLD at 2.5 per 100,000 births [10], and Japan was reported to have the lowest incidence at 0.16 per 100,000 births [16].

Table 2 Birth incidence and birth prevalence of MLD
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The percentage of MLD cases within leukodystrophies was reported in nine studies [11, 18,19,20,21,22,23,24,25] and ranged from 8.0% (country not reported) [18] to 42.4% (Saudi Arabia) [22]. One study reported a proportion lower than this range (3.0%), but it only included individuals who did not have diagnostic testing in another healthcare system and who had no previous family members with the same diagnosis [25]. The reported proportion of MLD within LSDs was reported in seven studies [12, 14, 16, 26,27,28,29] and ranged from 3.3% (Japan) to 47.6% (Tunisia); however, the inclusion criteria varied between the studies. Those reporting a higher proportion of MLD within leukodystrophies or LSDs tended to have a smaller study population or were conducted in countries with higher rates of consanguinity. Three studies reported the proportion of MLD in inborn errors of metabolism, which ranged from 1.4% to 18.2% [29,30,31]. Three studies reported the prevalence of MLD in lipidoses, which ranged from 18.0% to 30.2% [12, 17, 32].

Natural history

Age at symptom onset was reported in 51 studies [5, 9, 10, 22, 24, 32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77]. Across all studies, the range of ages at symptom onset (for individual patients) was 0.5–3 years for late-infantile MLD [9, 10, 34, 35, 38, 44, 45, 49,50,51, 53, 55, 57,58,59, 61,62,63,64,65, 72, 75, 77], 2–16 years for juvenile MLD (one study exclusively recruited early-symptomatic, early-juvenile patients) [9, 10, 34, 35, 45, 47, 49, 51,52,53, 55, 57, 63,64,65, 71, 72, 75, 77, 78], and 17–35 years for adult MLD [49, 72]. In most studies, mean age at symptom onset ranged from 16 to 18 months for the late-infantile subtype of MLD. For juvenile MLD, mean age at symptom onset ranged from 6 to 10 years [5, 9, 10, 22, 24, 32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77].

Age at diagnosis was reported in 19 studies [9, 12, 16, 22, 35, 39, 42, 44, 53, 60, 66, 72, 73, 79,80,81,82,83,84], of which seven [9, 53, 66, 79, 81,82,83] reported data for the different clinical subtypes of MLD. The age at diagnosis ranged from 0.4 to 8.6 years for late-infantile MLD [9, 12, 14, 16, 35, 44, 53, 72, 79, 81,82,83,84], from 3.0 to 21.6 years for juvenile MLD [9, 12, 14, 16, 35, 53, 72, 81, 82, 84], and from 17.0 to 35.3 years for adult MLD [72, 84]. Five of these studies reported children who received a diagnosis after an affected sibling [39, 42, 53, 72, 80].

Time to diagnosis from onset of symptoms was reported in 11 studies [9, 22, 38, 39, 53, 57, 69, 81, 85,86,87]. Based on five studies that reported MLD-subtype-specific data, the ranges for time to diagnosis from symptom onset were 0–7.1 years for late-infantile MLD, with one study that reported a range from “almost immediately” to 13 months [81], and 0.1–23.5 years for juvenile MLD [9, 53, 57, 81, 85]. It should be noted that some of the studies reporting data on age at symptom onset and age at diagnosis did not report data for untreated patients specifically; therefore, some of the patients may have received treatment during or before the study.

Genetic variants

Although genetic variation was not a prespecified outcome of interest in this review (see Table 1), any genotype information in the identified studies was recorded and is later summarized. ARSA variants associated with MLD were reported in 27 studies [5, 13, 15, 22, 24, 45, 49, 50, 52, 60,61,62, 66, 67, 69, 72, 75, 76, 80, 84, 88,89,90,91,92,93,94]. Most of these studies reported genetic variants per patient as a case series. Lugowska et al. [90] reported the distribution of two variants by MLD subtype in a population from 16 European countries. The c.459 + 1G > A variant was found at a rate of 25% in patients with MLD (194/768 patients) and was found more commonly in patients with late-infantile MLD (137/344 [40%]) than in other clinical subtypes of MLD (juvenile: 36/222 [16%]; adult: 15/160 [9%]). The p.P426L variant was found at a rate of 18.6% in patients with MLD (143/768 patients) and was considerably more common in juvenile MLD (66/222 [30%]) and adult MLD (68/160 [42.5%]) than in late-infantile MLD (3/344 [0.9%]). Note that some of these studies did not report data for untreated patients specifically, so some patients may have received treatment during or before the study.

Initial symptoms in untreated children

Qualitative descriptions of disease severity at baseline in untreated children were identified in 20 studies, all of which were observational studies [5, 9, 24, 34, 35, 38, 43, 45, 56, 57, 62, 65, 71, 72, 74, 75, 89, 92, 95, 96]. Patients with late-infantile MLD generally presented predominantly with motor symptoms and developmental delays, whereas patients with juvenile MLD generally presented with motor, cognitive, and behavioral symptoms. The initial presentation of adult MLD was typified by cognitive symptoms and psychiatric and mood disorders.

Thirteen studies reported differences in initial symptoms between the late-infantile and juvenile forms of MLD [5, 9, 24, 34, 35, 38, 49, 53, 57, 63, 65, 81, 86]. The findings of these studies are summarized in Table 3. Patients with early-juvenile MLD were more likely to have some level of motor impairment with cognitive deficits, whereas patients with late-juvenile MLD were more likely to have predominantly cognitive or behavioral symptoms [5, 34, 49].

Table 3 Comparison of initial symptoms reported in late-infantile and juvenile MLD
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The most frequently reported initial symptoms affecting motor function were gait disturbances, walking difficulties, frequent falls, and problems with balance, and the most frequently reported symptoms affecting cognitive function included learning difficulties, language acquisition, and behavioral changes. Other frequently reported initial symptoms were neuropathy, ataxia, seizures, tremor, and incontinence.

Gross Motor Function Classification in MLD (GMFC-MLD) level at baseline

The GMFC-MLD is a clinician-rated classification system of motor decline in MLD [97]. It has seven categories representing clinically relevant stages from normal (category 0) to loss of all locomotion (category 6) including head and trunk control [97]. GMFC-MLD level at disease baseline in untreated patients was reported in five studies, which are later described in detail [50, 56, 65, 72, 85]. Unless stated otherwise, baseline was defined as the patient’s GMFC-MLD level at the time of first assessment as reported by each study. There was a trend for patients with late-infantile MLD to have a higher baseline GMFC-MLD level than patients with juvenile or adult MLD.

Kehrer et al. reported GMFC-MLD levels in patients at the age of 18 months, which is the earliest age at which the scale can be reliably used. Gross motor function before 18 months was considered ‘normal’ if there was no evidence of motor regression and if developmental milestones were achieved at the expected chronological age. There was a significant difference between late-infantile and juvenile MLD; only 5/28 patients with late-infantile MLD had ‘normal’ gross motor function before the age of 18 months, whereas all patients with juvenile MLD had ‘normal’ motor function at this age (P < 0.001). At age 18 months, most patients with late-infantile MLD were at GMFC-MLD level 1 or 2 (level 0: n = 3; level 1: n = 7; level 2: n = 9; level 3: n = 3), whereas all patients with juvenile MLD were at level 0 [56].

Raina et al. retrospectively reported median GMFC-MLD levels in patients’ first recorded clinical, electroneurography, and neuroimaging examinations. Patients with late-infantile MLD tended to be at a higher level of GMFC-MLD than patients with juvenile MLD (late-infantile MLD [n = 4]: level 6 [range: 2–6]; juvenile MLD [n = 8]: level 2 [1–6]) [65].

Tillema et al. collected data on GMFC-MLD levels via a retrospective clinical chart review as part of a study in patients who had undergone magnetic resonance imaging (MRI) scans shortly after diagnosis. The study reported a median GMFC-MLD score of 1 (range: 0–6) for childhood-onset MLD (late-infantile MLD: n = 3; juvenile MLD: n = 11) and a median score of 0 (range: 0–1) for adult MLD (n = 6) [72].

Groeschel et al. reported cerebral volumetric changes as assessed by MRI in patients with late-infantile MLD (n = 18) and compared these cross-sectionally with those from typically developing children in the same age range (n = 42). The GMFC-MLD level for each patient with MLD at the time of MRI examination was reported; most patients were at the higher levels of GMFC-MLD

(level 1: n = 1; level 2: n = 4; level 3: n = 1; level 4: n = 1; level 5: n = 4; level 6: n = 7) [50].

Ammann-Schnell et al. reported the results of semi-standardized questionnaires completed by the parents of patients with MLD. At the time of the survey, parents reported a median GMFC-MLD level of 6 (range: 5–6) for patients with late-infantile MLD (n = 8) and 4.5 (0–6) for patients with juvenile MLD (n = 18) [85].

Comorbidities and complications

Comorbidities and complications related to MLD were reported in a cross-sectional manner in 35 studies [11, 15, 16, 20, 21, 24, 33, 36, 38, 39, 42, 43, 46, 47, 49, 55, 59,60,61, 64,65,66, 69, 74, 75, 78, 80, 81, 83, 86, 98,99,100,101,102]. Neuropathy, seizures, gallbladder abnormalities, incontinence, ataxia, epilepsy, and optic atrophy were reported in four or more studies (Fig. 2). Difficulties with swallowing were also reported in four studies, of which three also reported difficulties with breathing, and hypertonia or hypotonia were reported in three studies [15, 16, 21, 61, 81, 101]. Other comorbidities and complications reported (in single studies only) included scoliosis, unilateral left hip subluxation, spastic quadriparesis, dysarthria, visual loss, spasticity, dystonia, abnormal nerve conduction, metabolic acidosis, and decline in language [21, 61, 64, 99]. Additionally, one phenome-wide association study compared four specifical leukodystrophies (X-linked adrenoleukodystrophy, Hurler disease, Krabbe disease, and MLD) in a nationwide pediatric database and found that while developmental delay, epilepsy, fluid and electrolyte disturbances, and respiratory issues were shared morbidities in leukodystrophies, infantile cerebral palsy was uniquely associated with MLD [20].

Fig. 2
figure 2

MLD comorbidities and complications reported in three or more studies. Comorbidities and complications related to MLD were reported in 35 studies. MLD: metachromatic leukodystrophy

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Disease progression

Progression-related outcomes in untreated patients with MLD were described in 20 studies containing longitudinal data [5, 9, 39, 42, 45, 49,50,51,52,53, 55,56,57,58, 63, 71, 76, 87, 103, 104]. The findings from these studies are summarized in Table 4. Overall, patients with late-infantile MLD were reported to have a faster decline of motor function over time than patients with juvenile MLD (based on data from 10 studies) [9, 39, 53, 55, 56, 58, 61, 63, 76, 103]. Changes in cognitive function in patients with MLD from natural history cohorts were reported in nine studies [5, 45, 51,52,53, 57, 61, 76, 104], of which one study reported changes over time using the Bayley Scales of Infant Development, second edition [76]. Disease progression in MLD affecting eating and drinking was reported in six studies that included natural history cohorts [5, 39, 42, 49, 53, 55]. Impairment or decline in language was reported in five studies; none of these reported explicitly using the Expressive Language Function Classification in MLD [5, 45, 53, 57, 65].

Table 4 Studies reporting progression-related outcomes in untreated (natural history) cohorts
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Changes in GMFC-MLD scores over time were reported in nine studies that included untreated patients [5, 45, 49,50,51,52, 56, 71, 87]. Generally, children with late-infantile MLD had more rapid deterioration of gross motor function than children with juvenile-onset MLD. The age at entry into a certain GMFC-MLD category was reported to be more uniform in late-infantile than juvenile MLD [45, 56]. There was also some evidence of a positive correlation between demyelination load and GMFC-MLD scores [50, 51, 71].

Gross motor function (not assessed in relation to baseline GMFC-MLD) was reported in 10 studies that included untreated patients [9, 39, 53, 55, 56, 58, 61, 63, 76, 103]. Time of acquisition and loss of neuropsychomotor milestones were reported in one study [9]. Overall, these studies showed that patients with late-infantile MLD had faster declines of gross motor function over time than patients with juvenile MLD.

Mortality and survival

Data on mortality for untreated patients were reported in seven studies [10, 22, 49, 52, 61, 63, 101]. Mortality over time was reported in five studies [49, 52, 61, 63, 101], and the findings from these studies are summarized in Table 5. Survival measured from birth was reported in three studies [49, 61, 63], and survival measured from the onset of first symptoms was reported in three studies, of which two reported on mortality by clinical subtype [49, 52, 63]. Fumagalli et al. reported the 10-year survival rates from symptom onset for late-infantile MLD (40%) and early-juvenile MLD (80%), and found that survival rates were lower in patients with late-infantile MLD than in patients with juvenile MLD [49]. Van Rappard et al. reported that 8/22 untreated patients (36%) died 22–72 months after diagnosis [101]. Mahmood et al. found that, since 1921, the 10-year survival rates from symptom onset were 0%, 44.3%, and 69.6% for late-infantile, juvenile, and adult MLD, respectively. Further analysis by decades indicated increased survival over time for all types of MLD. Specifically, 5-year survival reported after 1990 was significantly higher than that reported prior to 1970 for all subtypes of MLD (late-infantile: 52% vs. 14%; juvenile: 100% vs. 46%; adult: 95% vs. 67%). The systematic review described by Mahmood et al. excluded studies that only included patients receiving transplants [63]. Mortality according to genetic variants was reported for a Saudi Arabian cohort through a 5-year time frame. In this study, 7/11 children with variants in ARSA had died, whereas 10/10 patients with PSAP variants were alive [22].

Table 5 Mortality over time and overall survival in untreated children with MLD
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Humanistic evidence

Four studies reported the impact of MLD on patients and caregivers, which are later described in detail [77, 81, 85, 105]. Pang et al. reported data on quality of life (QoL) for 21 patients with MLD and their caregivers. Caregivers in Germany, the UK, and the USA were asked to complete a Pediatric Quality of Life Inventory and an EuroQoL 5-dimension (EQ-5D) questionnaire. Most caregivers (71%) self-reported problems with anxiety/depression, and the mean EQ-5D index values were lower than those for the population norms for each of the three respective countries [77].

Ammann-Schnell et al. asked the parents and families of children with MLD (8 late-infantile and 21 juvenile-onset) about the impact of MLD on their QoL and general family functioning. All reported significantly lower health-related QoL (HRQoL) than the parents and families of unaffected children (P < 0.001), with mothers being more significantly affected than fathers (P < 0.05). Parents of children with late-infantile MLD reported worse HRQoL and family functioning than parents of children with the juvenile form of MLD, and scores worsened with increasing time from diagnosis and as children reached an advanced, terminal disease stage [85].

Eichler et al. conducted caregiver interviews to identify the specific clinical and QoL outcomes relevant for both patients with MLD and their caregivers. Caregivers reported that the most troublesome symptoms for them were immobility (9/30 caregivers) and respiratory difficulties (6/30), across all MLD subtypes (late-infantile, juvenile, and adult); however, patients reported that the most troublesome symptom for them was difficulty with communication (6/30), according to their caregivers. Caregivers reported considerable emotional burden, most commonly caused by the need to be confined to the home to provide care (16/30), relationship difficulties with spouses (6/30), feelings of fear (11/30), and depression or worry (8/30 each). Patients most commonly reported loss of autonomy (13/30) and their limited relationships with peers (9/30) as the most emotionally troublesome effects of their condition [81].

Pang et al. (2021) reported health state utility values for patients with infantile and juvenile MLD in the UK, developed through literature review and interviews with clinicians (n = 6) and caregivers (n = 21). Health states were defined by GMFC-MLD levels 0–6 and by Development Quotient scores for three cognitive functioning levels (normal/mild, moderate, and severe) for patients with juvenile MLD; late-infantile health states were defined by GMFC-MLD only. Clinicians reported that, from GMFC-MLD level ≥ 2, patients experienced significant symptoms, with significant overlap between levels, from level 2 to level 6. Reported symptoms included problems with swallowing, muscle spasms, digestive issues, seizures, and sleep. Health states were valued by 101 members of the UK general public via visual analog scale and time trade-off (TTO) assessment, including the lead-time method. Lead-time TTO is a method whereby individuals express their preferences for different health states by hypothetically trading between QoL and quantity of life, without having to consider whether these states are better or worse than being dead [106]. For late-infantile MLD health states, mean TTO values ranged from 0.71 for GMFC-MLD level 1 to − 0.47 for GMFC-MLD

level 6. Utility values were lower for juvenile health states than for late-infantile health states and worsened with cognitive status: in the normal/mild cognitive group, mean utility values ranged from 0.90 for GMFC-MLD level 1 to − 0.07 for GMFC-MLD level 4; in the moderate cognitive group, mean scores ranged from 0.85 for GMFC-MLD level 0 to − 0.62 for GMFC-MLD level 6; and in the severe group, mean scores ranged from 0.37 for GMFC-MLD level 0 to − 0.70 for GMFC-MLD level 5 [105].

Economic evidence

Two studies reported resource use for untreated patients with MLD [81, 82]. One study reported healthcare resource use post-MLD diagnosis for 24 patients with MLD (12 late-infantile and 12 juvenile) in the UK.

Overall, these patients had a mean of 3.7 (standard deviation [SD] 7.2) outpatient hospital attendances per patient-year (4.0 [SD 9.9] for patients with late-infantile MLD; 3.4 [SD 3.1] for patients with juvenile MLD). Mean elective inpatient admissions per patient-year were 2.6 (SD 8.8) for patients with late-infantile MLD and 0.1 (SD 0.2) for patients with juvenile MLD (1.4 [SD 6.2] per patient-year overall). Overall, patients with MLD had a mean of 0.05 (SD 0.10) day case admissions per patient-year [82]. In another study of patients from Colombia, France, Germany, and the USA, 12/22 caregivers interviewed reported that their respective patients required an average of 1–3 visits to primary care practitioners per month, and nine reported an average of 1–3 specialist visits per month. Eight patients had required at least 11 hospitalizations since diagnosis; however, given that the two studies used different measures of economic impacts, these results cannot be directly compared [81].

Discussion

This SLR offers a comprehensive and robust analysis of topics related to the natural history and burden of illness of MLD, having been designed and conducted using methodology in accordance with the 2020 PRISMA guidelines. To our knowledge, it is the first SLR to provide a broad overview of these areas, complementing a previous SLR that summarized mortality data in studies of MLD from 1920 to June 30, 2006 [63]. The data reported show that the disease course varies widely between patients with MLD and that patients exhibit a wide range of signs, symptoms, comorbidities, and complications. These data also provide an important comparator dataset for outcomes when evaluating the effects of new disease-modifying therapies for MLD.

The wide variation in age at diagnosis and time to diagnosis reported in this SLR is likely to be due to differences in diagnostic methods over time and between countries; it also highlights the unmet need for early diagnosis of patients with MLD. Increased disease awareness and more frequent and widespread diagnosis of presymptomatic patients through newborn screening would help to reduce the wide variation in age at diagnosis and time to diagnosis for this disease. Crucially, newborn screening for MLD has been shown to be possible in a real-world scenario and to have a high degree of support among caregivers of patients with MLD, although a number of challenges to its implementation remain [107,108,109,110,111]. Various prospective screening pilots are ongoing, and between October 2021 and August 2022, a program in Germany screened ~ 50,000 babies and identified four ARSA heterozygotes, one of whom was MLD positive [112]. Improved availability of newborn screening would also help to increase the proportion of patients who are eligible for gene therapy [113,114,115].

Patients with MLD experience a high disease burden that increases as the disease progresses, with commonly reported comorbidities and complications including seizures, ataxia, and optic atrophy. Although patients with MLD typically die prematurely, data from a previous SLR suggest that survival has improved over time for all clinical subtypes of MLD [63]. Currently, little evidence is available on time to loss of motor function, although this may be a more useful measure than mortality for understanding disease progression and its subsequent impact on QoL.

Typically, patients with late-infantile MLD have earlier onset, a more rapid decline of motor function over time, higher GMFC-MLD levels, and lower survival than patients with juvenile MLD. Patients with late-infantile MLD typically present predominantly with motor function symptoms and delays in reaching developmental milestones, whereas patients with juvenile MLD usually present with motor, cognitive, and behavioral symptoms. In the initial presentation of the late-juvenile and adult subtypes, cognitive symptoms predominate. These findings are generally consistent with the clinical presentation of patients with different MLD subtypes in a recent study [116]. However, in this study only a small proportion of patients with late-juvenile MLD (1/12, 8%) had a cognitive-only phenotype, suggesting that the clinical phenotype of patients with late-juvenile MLD varies widely [116]. In a study of descriptions given by caregivers of children with MLD (20 late-infantile, 11 juvenile, 1 borderline late-infantile/juvenile), coordination difficulties, clonus/tremors, and comprehension challenges were identified as the most common initial signs and symptoms of MLD, supporting their frequent documentation in this SLR [117]. The wide variation in signs, symptoms, and disease progression among patients with MLD, combined with the need for early diagnosis to facilitate prompt treatment initiation, mean that there is a need to be able to predict clinical subtype and disease progression, which some studies have begun to investigate [118, 119]. For example, data from a recent study suggest that early developmental delay can precede neurologic regression in patients with late-infantile MLD [120].

Available evidence shows that MLD has a clear impact on the QoL of patients and families, with patients being particularly affected by loss of autonomy and limited relationships with peers, and that caregivers were found to report high levels of anxiety and depression [77, 81]. Supporting this, in a recent study of caregivers of patients with late-infantile MLD, most felt that delaying the decline in gross motor function would have a meaningful impact on patients [121]. Overall, these findings highlight the need for psychological support for patients with MLD and their families.

Key knowledge gaps include data on mortality by clinical subtype, humanistic and economic outcomes, and differences between the early- and late-juvenile MLD subtypes. Since this SLR was conducted, an additional study on the impact of MLD on caregivers has been published [122]. In this study, the EQ-5D questionnaire was administered to caregivers of patients with MLD in Belgium, France, Germany, Norway, and the USA. In line with the findings from Pang et al. [77], caregivers had EQ-5D values below national population norms and reported high levels of anxiety/depression. Differences between caregivers of patients with late-infantile MLD compared with those of patients with juvenile MLD were also observed; the former group was more likely to report a negative impact on familial relationships, and the latter group reported more lifestyle changes and dissatisfaction with their personal lives [122].

In addition to the knowledge gaps described earlier, there were also insufficient epidemiological data to compare incidence and prevalence by country or region, in part owing to varying methodology and study periods between publications. Data on disease course, such as reports of signs and symptoms, were mainly qualitative, limiting the collation of data across studies. Improved reporting of quantitative data on signs and symptoms, such as measurements of ASA activity or biomarker levels, could help to facilitate predictions of the disease course and inform treatment decisions [118, 119].

The studies included in this SLR covered a broad geographical evidence base, and a substantial number of studies reported detailed baseline characteristics and outcomes separately for the different clinical subtypes of MLD. Quality assessment was performed using the ROBINS-I tool for non-randomized interventional clinical studies and informally for non-interventional studies. Limitations include those common among SLRs, such as the possibility that some relevant studies may not have been detected by the searches if they did not mention any terms of interest in their titles or abstracts; this limitation results from balancing the need to compromise between identifying all relevant evidence and limiting searches so that the scope of the review remains focused and manageable. Another limitation was that data in figures without detailed labeling could not be extracted in full, meaning that, for these, only trends could be determined.

MLD is a devastating disease that shortens life and reduces QoL, especially as the disease progresses. Further studies on clinical, humanistic, and economic outcomes, particularly by clinical subtype, will help to inform healthcare decisions for patients with MLD.

Availability of data and materials

Data sharing not applicable because no new data were generated.

Abbreviations

AE:

Adverse event

ANA:

American ARSA, arylsulfatase A gene

ASA:

Arylsulfatase A

CI:

Confidence interval

CRD:

Centre for Reviews and Dissemination

CSF:

Cerebrospinal fluid

ELFC-MLD:

Expressive Language Function Classification in MLD

EQ-5D:

EuroQol 5-dimension questionnaire

GMFC-MLD:

Gross Motor Function Classification in MLD

GMFM-88:

88-Item Gross Motor Function Measure

HRQoL:

Health-related QoL

HSCT:

Hematopoietic stem cell transplant

LQLA:

Leukodystrophy Quality of Life Assessment

LSD:

Lysosomal storage disease

MLD:

Metachromatic leukodystrophy

MRI:

Magnetic resonance imaging

MRS:

Magnetic resonance spectroscopy

PedsQL:

Pediatric Quality of Life Inventory

PICOS:

Participants, Interventions, Comparators, Outcomes, and Study design

PRISMA:

Preferred Reporting Items for Systematic review and Meta-Analysis

PSAP:

Prosaposin

QoL:

Quality of life

RCT:

Randomized controlled trial

ROBINS-I :

Risk Of Bias In Non-randomized Studies - of Interventions

SAPB:

Sphingolipid activator protein B

SD:

Standard deviation

SLR:

Systematic literature review

TEAE:

Treatment-emergent adverse event

TTO:

Time trade-off

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Acknowledgements

The authors would like to thank Robert Walsh, Marta Radwan, and Caroline Freeman of Oxford PharmaGenesis, Oxford, UK for supporting the SLR process. Under the direction of the authors, medical writing support was provided by Rebecca Burge PhD of Oxford PharmaGenesis, Oxford, UK, and was funded by Takeda Development Center Americas, Inc.

Funding

This study was funded by Takeda Development Center Americas, Inc.

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Authors and Affiliations

  1. Takeda Development Center Americas, Inc., 125 Binney Street, Cambridge, MA, USA

    Shun-Chiao Chang

  2. Oxford PharmaGenesis, Oxford, UK

    Christian Stefan Eichinger & Polly Field

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  2. Christian Stefan Eichinger
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Contributions

S-CC, CE, and PF designed, conducted, and analyzed the SLR and reviewed the manuscript.

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Correspondence to Shun-Chiao Chang.

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Competing interests

S-CC is an employee of Takeda Pharmaceutical Company Limited with ownership interest less than 5%. CE is an employee of Oxford PharmaGenesis Limited. PF is an employee of Oxford PharmaGenesis Limited with ownership interest less than 5%.

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Chang, SC., Eichinger, C.S. & Field, P. The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review. Eur J Med Res 29, 181 (2024). https://doi.org/10.1186/s40001-024-01771-1

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Keywords

European Journal of Medical Research

ISSN: 2047-783X

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