Articles

Retraction Note to: Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and susceptibility to lung cancer

Authors: Wei Zhou, Shuxiang Zhang, Yingchun Hu, Jianrong Na, Na Wang, Xuan Ma, Lizhi Yuan and Fanzhen Meng

Erratum to: Breast reconstruction after neoadjuvant radio chemotherapy: review and personal technique IDEAL concept

Authors: Carolin Nestle-Krämling, Edwin Bölke, Wilfried Budach and Christoph Andree

Stem cell procedures in arthroscopic surgery

The stem cell as the building block necessary for tissue reparation and homeostasis plays a major role in regenerative medicine. Their unique property of being pluripotent, able to control immune process and e...

Authors: Felix Dyrna, Elmar Herbst, Alexander Hoberman, Andreas B. Imhoff and Andreas Schmitt

Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China

Studies have been reported that cyclin-dependent kinase5 (CDK5) was associated with the development of several cancers. However, the relationship between CDK5 level and clinicopathological factors is still poo...

Authors: Deng-Hua Pan, Mei-Lin Zhu, Xiao-Miao Lin, Xing-Gu Lin, Rong-Quan He, Yan-Xin Ling, Shi-Tao Su, Madushi Mihiranganee Wickramaarachchi, Yi-Wu Dang, Kang-Lai Wei and Gang Chen

Modified Hughes procedure for reconstruction of large full-thickness lower eyelid defects following tumor resection

Tarsoconjunctival flap advancement, or the Hughes procedure, is among the techniques of choice for reconstructing full-thickness lower eyelid defects so as to restore normal anatomy and function with the best ...

Authors: Ahmed M. Hishmi, Konrad R. Koch, Mario Matthaei, Edwin Bölke, Claus Cursiefen and Ludwig M. Heindl

HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma

Histone deacetylation, a common hallmark in malignant tumors, strongly alters the transcription of genes involved in the control of proliferation, cell survival, differentiation and genetic stability. We have ...

Authors: Reena Buurman, Maria Sandbothe, Brigitte Schlegelberger and Britta Skawran

sMICA as novel and early predictors for acute myocardial infarction

MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection, various types of stress, such as endoplasmic reticulum stress, and ischemia or/and reperfusion, by which MICA ...

Authors: Cunyu Fu, Yunxiang Shi and Zongqin Yao

Breast reconstruction after neoadjuvant radio chemotherapy: review and personal technique IDEAL concept

Neoadjuvant radio chemotherapy and immediate reconstruction for breast cancer are still under debate. But there are recent abstracts and articles which show that neoadjuvant radio chemotherapy is feasible and ...

Authors: Carolin Nestle-Krämling, Edwin Bölke, Wilfried Budach and Christoph Andree

Association of IL-10 polymorphisms with hepatitis B virus infection and outcome in Han population

This study evaluated the correlation of single nucleotide polymorphisms interleukin (IL)-10-592 and -1082 with hepatitis B virus (HBV) susceptibility and recovery.

Authors: Lei Gao, Xi Chen, Lian Zhang, Di Wu, He Zhao and Junqi Niu

Serum prolactin as a biomarker for the study of intracerebral dopamine effect in adult patients with phenylketonuria: a cross-sectional monocentric study

It has been previously postulated that high phenylalanine (Phe) might disturb intracerebral dopamine production, which is the main regulator of prolactin secretion in the pituitary gland. Previously, various a...

Authors: Eszter Juhász, Erika Kiss, Erika Simonova, Attila Patócs and Peter Reismann

Longitudinal strain bull’s eye plot patterns in patients with cardiomyopathy and concentric left ventricular hypertrophy

Despite substantial advances in the imaging techniques and pathophysiological understanding over the last decades, identification of the underlying causes of left ventricular hypertrophy by means of echocardio...

Authors: Dan Liu, Kai Hu, Peter Nordbeck, Georg Ertl, Stefan Störk and Frank Weidemann

The value of initial cavitation to predict re-treatment with pulmonary tuberculosis

Pulmonary cavitation is the classic hallmark of pulmonary tuberculosis (PTB) and is the site of very high mycobacterial burden associated with antimycobacterial drug resistance and treatment failure. The objec...

Authors: Qiusheng Huang, Yongmei Yin, Shougang Kuai, Yan Yan, Jun Liu, YingYing Zhang, Zhongbao Shan, Lan Gu, Hao Pei and Jun Wang

A novel LAMB2 gene mutation associated with a severe phenotype in a neonate with Pierson syndrome

Pierson syndrome (PS) is a rare autosomal recessive disorder, caused by mutations in the laminin β2 (LAMB2) gene. It is characterized by congenital nephrotic syndrome, microcoria, and neurodevelopmental defici...

Authors: Boutaina Zemrani, François Cachat, Olivier Bonny, Eric Giannoni, Jacques Durig, Florence Fellmann and Hassib Chehade

Clinical application of computed tomography-guided ¹²⁵I seed interstitial implantation for head and neck cancer patients with unmanageable cervical lymph node metastases

To assess clinical application of computed tomography (CT)-guided ¹²⁵I seed implantation for patients who cannot endure or unwillingly receive repeated surgery, chemotherapy, or radiotherapy for unmanageable cerv...

Authors: Hai Huang, Shaonian Xu, Fusheng Li, Zhenguang Du and Liang Wang

Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Lung cancer is one of the most preventable causes of death globally both in developed and developing countries. Although it is well established that smokers develop lung cancer, there are some smokers who are ...

Authors: Vidyullatha Peddireddy, Siva Prasad Badabagni, Sandhya Devi Gundimeda, Vasudha Mamidipudi, Pardhanandana Reddy Penagaluru and Hema Prasad Mundluru

Hepatitis B and human immunodeficiency virus co-infection among pregnant women in resource-limited high endemic setting, Addis Ababa, Ethiopia: implications for prevention and control measures

Hepatitis, a highly contagious viral infection, is one of the leading killer diseases globally caused by hepatitis virus. Among the existing viral causes for hepatic failure, hepatitis B virus (HBV) plays a si...

Authors: Zelalem Desalegn, Liya Wassie, Habtamu Bedimo Beyene, Adane Mihret and Yehenew A. Ebstie

Reduction and stabilization of radial neck fractures by intramedullary pinning: a technique not only for children

Isolated radial neck fractures occur only in rare cases. The majority of cases are non-displaced or minimally displaced and can be treated conservatively. Conservative treatment, however, might result in secon...

Authors: G. H. Sandmann, M. Crönlein, M. Neumaier, M. Beirer, A. Buchholz, U. Stöckle, P. Biberthaler and S. Siebenlist

Vitamin D and airway infections: a European perspective

Vitamin D has immuno-modulatory properties, and deficient levels of circulating 25-hydroxyvitamin D (<30 nmol/l) may contribute to increased risk of infectious illnesses. This narrative review summarises data ...

Authors: Armin Zittermann, Stefan Pilz, Harald Hoffmann and Winfried März

Association between hypertension and deep vein thrombosis after orthopedic surgery: a meta-analysis

We aimed to analyze the association between hypertension and deep vein thrombosis (DVT) after orthopedic surgery.

Authors: Lei Huang, Jie Li and Yong Jiang

Is the distal radioulnar variance useful for identification of radial head prosthesis overlengthening? A cadaver study

Overlengthening by radial head prosthetic replacement leads to insufficient functionality and increased capitellar wear. It has been shown that in monopolar prostheses, the radial overlengthening by an overstu...

Authors: Kilian Wegmann, Wei Zhang, Volker Strauss, Christian Ries, Lars P. Müller and Klaus J. Burkhart

How rapid is rapid? Exemplary results of real-life rapid rule-out troponin timing in troponin-positive acute coronary syndromes without persistent ST-segment elevation in two contrasting German chest pain unit facilities

To analyse the timing of cardiac troponin (cTn) measurements in high-risk and cTn-positive acute coronary syndromes without persistent ST-segment elevation (NSTE-ACS) in two structurally different German chest...

Authors: Dieter Fischer, Friederike Remberg, Dirk Böse, Michael Lichtenberg, Philipp Kümpers, Pia Lebiedz, Hermann-Joseph Pavenstädt, Johannes Waltenberger and Frank Breuckmann

An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors

Pathological examination combined with tumor markers has become a standard for the diagnosis of intracranial germ cell tumors (ICGCTs), but the current concept of ‘secreting germ cell tumors’ and three empiric...

Authors: Mingming Hu, Hongzhi Guan, Ching C. Lau, Keita Terashima, Zimeng Jin, Liying Cui, Yuzhou Wang, Guilin Li, Yong Yao, Yi Guo, Yan Michael Li, Dingrong Zhong, Juan Xiao, Xirun Wan, Xin Lian, Feng Feng…

One-lung flooding reduces the ipsilateral diaphragm motion during mechanical ventilation

Diaphragm motion during spontaneous or mechanical respiration hinders image-guided percutaneous interventions of tumours in lung and upper abdomen. Motion-tracking methods can be applied but increase procedure...

Authors: Thomas Günther Lesser, Harald Schubert, Daniel Güllmar, Jürgen R. Reichenbach and Frank Wolfram

Total hip arthroplasty-related osteogenic osteosarcoma: case report and review of the literature

Orthopedic implant-related sarcoma is an exceedingly rare, but a known complication of total hip arthroplasty (THA).

Authors: Rajko Kavalar, Samo K. Fokter and Janez Lamovec

Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model

The rabbit disc model is useful for the study of intervertebral disc (IVD) degeneration and experimental therapeutic interventions. The annulotomy-induced disc models present several drawbacks, particularly an...

Authors: Long Xin, Chun Zhang, Fuhua Zhong, Shunwu Fan, Wei Wang and Zhenbin Wang

Thanks to all those who reviewed for European Journal of Medical Research in 2015

Authors: Dieter Häussinger and Johannes Waltenberger

Hyaluronidase: from clinical applications to molecular and cellular mechanisms

Over the past 60 years, hyaluronidase has been successfully utilized in ophthalmic surgery and is now being implemented in dermatosurgery as well as in other surgical disciplines. The enzyme is considered a “s...

Authors: Bettina Alexandra Buhren, Holger Schrumpf, Norman-Philipp Hoff, Edwin Bölke, Said Hilton and Peter Arne Gerber

Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model

Laparoscopic Surgery has become a worldwide standard procedure for a variety of indications. This has been attributed to a milder postoperative inflammatory response by the innate immune system potentially med...

Authors: Philipp Lingohr, Jonas Dohmen, Hanno Matthaei, Nils Konieczny, Juliane Hoffmann, Edwin Bölke, Sven Wehner and Jörg C. Kalff

Erratum to: Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis

Authors: Yeon-Ho Kang, Sujeong Park, Chihyun Ahn, Jinsoo Song, Dongkyun Kim and Eun-Jung Jin

Focal colorectal uptake in ¹⁸FDG-PET/CT: maximum standard uptake value as a trigger in a semi-automated screening setting

Focal colorectal uptake in ¹⁸FDG-PET/CT may be associated with a malignancy and can be quantified. This provides the basis for an automatic trigger threshold above which cases are flagged for colonoscopic evaluat...

Authors: Wolfgang Luboldt, Baerbel Wiedemann, Sebastian Fischer, Boris Bodelle, Hans Joachim Luboldt, Frank Grünwald and Thomas J. Vogl

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).

Authors: Robert Rozenberg, Robert T. Mankowski, Luc J. C. van Loon, Janneke G. Langendonk, Eric J. G. Sijbrands, Anton H. van den Meiracker, Henk J. Stam and Stephan F. E. Praet

Melkersson–Rosenthal syndrome as an early manifestation of mixed connective tissue disease

We aim to illustrate the potential viability of MCTD as an underlying aetiology of Melkersson–Rosenthal syndrome. The case is probably the first description available in the literature of the Melkersson–Rosen...

Authors: Dorota Jasinska and Jerzy Boczon

Visualization of stress fractures of the foot using PET-MRI: a feasibility study

Diagnosis and treatment of stress fractures still remains to be a clinical and radiological challenge. Therapeutic options vary from conservative treatment to surgical treatment without a clear treatment conce...

Authors: Moritz Crönlein, Isabel Rauscher, Ambros J. Beer, Markus Schwaiger, Christoph Schäffeler, Marc Beirer, Stephan Huber, Gunther H. Sandmann, Peter Biberthaler, Matthias Eiber and Chlodwig Kirchhoff

IL-17 promoted the inhibition of medulloblastoma in mice by splenocyte injection

Interleukin 17 (IL-17) is a proinflammatory cytokine produced by a new subset of activated CD4+ T cells, Th17 cells. We previously showed that increased Th17 cell populations were presented in human medullobla...

Authors: Ping Zhou, Qilin Zhang, Yao Zhao, Hongying Sha, Xiaoyun Cao and Yongfei Wang

Endoscopic approach to the resection of adenoid cystic carcinoma of paranasal sinuses and nasal cavity: case report and own experience

Adenoid cystic carcinoma (ACC) is a rare malignant tumor that might occur in nasal cavity and paranasal sinuses. It is characteristic for poor prognosis, especially the solid histopathological subtype of the t...

Authors: Piotr Wardas, Michał Tymowski, Agnieszka Piotrowska-Seweryn, Wojciech Kaspera, Aleksandra Ślaska-Kaspera and Jarosław Markowski

Cerebral reactivity in migraine patients measured with functional near-infrared spectroscopy

There are two major theories describing the pathophysiology of migraines. Vascular theory explains that migraines resulted from vasodilation of meningeal vessels irritating the trigeminal nerves and causing pa...

Authors: Ahmadreza Pourshoghi, Arash Danesh, David Stuart Tabby, John Grothusen and Kambiz Pourrezaei

Specific microRNAs as novel biomarkers for combination chemotherapy resistance detection of colon adenocarcinoma

Colon cancer is a frequently occurring primary malignant tumor. Chemotherapy can reduce the risk of local and distant relapse. Therefore, it is very important to find new biomarkers that can predict chemoresis...

Authors: Jinsong Hu, Ye Xu and Sanjun Cai

Male breast carcinoma: radiotherapy contributed to favorable local control in two cases and related literature review

Male breast carcinoma (MBC) is rarely encountered in clinical practice. Due to its paucity, our knowledge of MBC only rely on small or single-institutional studies and sporadic cases. The current guidelines fo...

Authors: Min Liu, Qiang Wang, Bin Liu, Ling Gao, Di Wu, Shuo Yang, Bailong Liu and Lihua Dong

Pronator quadratus repair after volar plating of distal radius fractures or not? Results of a prospective randomized trial

The purpose of the present study was to investigate the influence of the pronator quadratus (PQ) muscle repair following volar plate fixation of distal radius fractures with special regards to the forearm pron...

Authors: Sandra Häberle, Gunther Hubertus Sandmann, Stephan Deiler, Tobias Maximilian Kraus, Florian Fensky, Tobias Torsiglieri, Ina-Christine Rondak, Peter Biberthaler, Ulrich Stöckle and Sebastian Siebenlist

Comparison of preoperative evaluation of malignant low-level biliary obstruction using plain magnetic resonance and coronal liver acquisition with volume acceleration technique alone and in combination

To evaluate the clinical value of plain magnetic resonance (MR) imaging (including magnetic resonance cholangiopancreatography, MRCP) and coronal liver acquisition with volume acceleration (LAVA) technique in ...

Authors: Nana Sun, Qing Xu, Xisheng Liu, Wei Liu and Jianwei Wang

Acute trophoblastic pulmonary embolism during conservative treatment of placenta accreta: case report and review of literature

Placenta accreta is a rare obstetric condition but can lead to life-threatening complications that was mainly diagnosed in the third trimester. We present a case of acute trophoblastic pulmonary embolism (PE) ...

Authors: Qiu-ming Wang, Hui-li Liu and Qun Dang

The association between physical activity and sexual dysfunction in patients with diabetes mellitus of European and South Asian origin: The Oxford Sexual Dysfunction Study

The present study aims to evaluate the relationship between physical activity and sexual dysfunction amongst an ethnic South Asian population living in the United Kingdom and compare the association with that ...

Authors: Lasantha S. Malavige, Pabasi Wijesekara, Priyanga Ranasinghe and Jonathan C. Levy

Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis

Glucosamine is widely used to improve the symptoms and to delay the structural progression of osteoarthritis. However, its efficacy in osteoarthritis has been controversial and its underlying mechanism of acti...

Authors: Yeon-Ho Kang, Sujeong Park, Chihyun Ahn, Jinsoo Song, Dongkyun Kim and Eun-Jung Jin

Anterior arthroscopic-assisted fixation of posterior cruciate ligament avulsion fractures

Avulsion fractures of the tibial insertion of the posterior cruciate ligament (PCL) have always been regarded as rare injuries. The tibial attachment of the PCL is located in an area, which is difficult to acc...

Authors: Wei Huang, Xuan Gong, Mishra Rahul, Shukla Priyanka, Changdong Wang, Xi Liang, Guoliang Ding and Ning Hu

Malpositioned olecranon fracture tension-band wiring results in proximal radioulnar synostosis

Tension-band wiring (TBW) is a well-established fixation technique for two-part, transverse fracture types of the olecranon. However, complication rates up to 80 % are reported. By reporting on the enormous im...

Authors: Lukas Willinger, Martin Lucke, Moritz Crönlein, Gunther H. Sandmann, Peter Biberthaler and Sebastian Siebenlist

The value of liver resection for focal nodular hyperplasia: resection yes or no?

Focal nodular hyperplasia (FNH) are benign lesions in the liver. Although liver resection is generally not indicated in these patients, rare indications for surgical approaches indeed exist. We here report on ...

Authors: Hans Michael Hau, Georgi Atanasov, Hans-Michael Tautenhahn, Rudolf Ascherl, Georg Wiltberger, Markus Bo Schoenberg, Mehmet Haluk Morgül, Dirk Uhlmann, Michael Moche, Jochen Fuchs, Moritz Schmelzle and Michael Bartels

PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China

Germline mutations in PALB2 gene make a small contribution to heritable breast cancer susceptibility. A recent report has revealed that women with mutations in the PALB2 gene were more than nine times as like...

Authors: Yong Tao Li, Wei Hua Jiang, Xiao Wen Wang, Ming Shuai Zhang, Cheng Guang Zhang, Li Na Yi, Fulati WuwaliKhan, Aisikaer Ayoufu and Jiang Hua Ou

HLA-DR expression on monocytes is decreased in polytraumatized patients

Sepsis, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) remain the most frequent causes of complications and death in severely injured patients. A main reason for ...

Authors: Helen Vester, P. Dargatz, S. Huber-Wagner, P. Biberthaler and M. van Griensven

Extracorporeal cardiopulmonary resuscitation for adult patients who underwent post-cardiac surgery

Refractory cardiac arrest (CA) occasionally develops in patients after cardiac surgery.

Authors: Yanyan Zhao, Jialin Xing, Zhongtao Du, Feng Liu, Ming Jia and Xiaotong Hou

Syphilis and neurosyphilis: HIV-coinfection and value of diagnostic parameters in cerebrospinal fluid

Neurosyphilis might be difficult to diagnose particularly in asymptomatic patients and patients with HIV-coinfection. The objective of this study was to evaluate current diagnostic standards for neurosyphilis ...

Authors: V. Merins and K. Hahn