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EuroScore and IL-6 predict the course in ICU after cardiac surgery

Abstract

Background

Despite modern advances in intensive care medicine and surgical techniques, mortality rates in cardiac surgical patients are still about 3%. Considerable efforts were made to predict morbidity and mortality after cardiac surgery. In this study, we analysed the predictive properties of EuroScore and IL-6 for mortality in ICU, prolonged postoperative mechanical ventilation, and prolonged stay in ICU.

Methods

We enrolled 2972 patients undergoing cardiac surgery. The patients either underwent aortic valve surgery (AV), mitral valve surgery (MV), coronary artery bypass grafting (CABG), and combined operations of aortic valve and coronary artery bypass grafting (AV + CABG) or of mitral and tricuspid valve (MV + TV). Different laboratory and clinical parameters were analysed.

Results

EuroScore as well as IL-6 were associated with increased mortality after cardiac surgery. Furthermore, a higher EuroScore and elevated levels of IL-6 were predictors for prolonged mechanical ventilation and a longer stay in ICU. Especially, highly significant elevated IL-6 levels and an increased EuroScore showed a strong association. Statistics suggested superiority when both parameters were combined in a single model.

Conclusion

Our results suggest that EuroScore and IL-6 are helpful in predicting the course in ICU after cardiac surgery, and therefore, the use of intensive care resources. Especially, the combination of highly elevated levels of IL-6 and EuroScore may prove to be excellent predictors for an unfortunate postoperative course in ICU.

Introduction

Over the last decades, an astonishing progress was registered in cardiac surgery [1]. Operations of most complex cardiovascular pathologies and abnormalities have become somehow routine nowadays [2]. Despite modern advances in intensive care medicine and surgical techniques, mortality rates (within 30 days after surgery) in all cardiac surgical patients are still about 3% [3, 4].

Considerable efforts were made to predict postoperative morbidity and mortality after cardiac surgery in the past [5,6,7]. Several studies attempted to find single predictors or developed algorithms and scoring systems to identify patient characteristics with an increased risk of an adverse outcome after surgery [8, 9]. One of the most established predictive models is the European System for Cardiac Operative Risk Evaluation (EuroScore) [9]. The EuroScore is a simple-to-use, objective, and well validated scoring system to predict early mortality after cardiac surgery [9]. Patient characteristics, as well as cardiac and operation related risk variables are collected and weighted differently within this model [9]. It considers previous cardiac surgery, emergency surgery other than isolated coronary artery bypass grafting (CABG), and surgery on thoracic aorta [9]. The use of the EuroScore to predict mortality (30 days from operation or later than 30 days if the patient is still in the hospital) is well documented in the literature [10]. Its association with postoperative parameters is less well investigated. An association of the EuroScore and the length of stay in ICU after cardiac surgery was shown in a recent research conducted at a single centre in the UK [11]. The role of EuroScore to predict other postoperative parameters like length of mechanical ventilation seems to be unknown.

Recent research showed that systemic inflammation after cardiac surgery is associated with an increased mortality [12]. While the EuroScore considers several important clinical parameters, the inflammatory response after cardiac surgery is not included. The inflammatory response in the setting of cardiac surgery can most likely be explained by surgical trauma, cardiopulmonary bypass, and reperfusion injury [13, 14]. Interleukin-6 (IL-6) is induced by tumour necrosis factor (TNF)-α and reflects the localized TNF-α activity suggesting a major role of TNF-α and IL-6 in the inflammatory response after cardiac surgery [13, 14]. However, the association of IL-6 with short-term outcome after cardiac surgery has not been investigated yet.

Therefore, the aim of our study was to investigate the association and possible predictive properties of (i) the EuroScore and (ii) IL-6 serum levels for mortality in ICU, prolonged postoperative mechanical ventilation, and prolonged stay in ICU after cardiac surgery.

Material and methods

The study followed the principles of the Declaration of Helsinki and was approved by the Institutional Review Board of the Ludwig Maximilians University Munich (approval number: 748-15).

Patients

We retrospectively analysed the records of 2972 patients who underwent either CABG, aortic valve surgery (AV), combined operation of aortic valve and coronary artery bypass grafting (AV + CABG), mitral valve surgery (MV), and combined operation of mitral and tricuspid valve (MV + TV) at the University of Munich (LMU; Herzklinik der Universität München am Augustinum) over a period of 5 years. None of the patients had signs of infection in either clinical examination or laboratory testing.

Recorded parameters

The documented parameters analysed in this study were: age, sex, ejection fraction (EF) and serum creatinine level before operation, duration of cardiopulmonary bypass (CPB), length of stay in the ICU, length of mechanical ventilation, serum levels of interleukin 6 (IL-6) 6 h after operation, additive EuroScore (calculated during the pre-operative assessment), and death after cardiac surgery.

ICU procedures

All operations were performed under extracorporeal circulation. Clinical management (mechanical ventilation, extubation, fluid management, catecholamine support, and discharge from the ICU) was performed according to a standardized protocol. All patients were mechanically ventilated at admission to the ICU. Tracheal extubation was performed after a period of spontaneous breathing according to the following criteria: absence of residual muscle paralysis, adequate ventilatory parameters, patient awake, and cooperative. Fluid therapy was guided by transoesophageal echocardiography and haemodynamic monitoring. Normovolemia was achieved by infusions of crystalloids and colloids.

Discharge from the ICU required the following criteria: hemodynamic stability without pharmacological support, adequate gas exchange, no signs of bleeding or systemic infections, and adequate urine output.

Statistical analyses

In a first step, we analysed different possible predictors for mortality in ICU after surgery. Investigated variables were the EuroScore and IL-6 serum levels. Furthermore, we included age (linear in years), sex, pre-operative serum creatinine levels, duration of cardiopulmonary bypass, EF, and kind of cardiac surgery. For this, we fitted univariable logistic regression models with death as outcome variable. In a second step, we investigated different possible predictors for (a) duration of ventilation after surgery and (b) duration of stay in ICU after surgery. We included the same exposure variables as listed above. We fitted univariable and multivariable logistic regression models. In multivariable models we further tested for interactions between EuroScore and IL-6 serum levels and the other included variables using likelihood ratio tests. As the EuroScore could not be obtained in a small number of patients, we performed sensitivity analyses, repeating analyses for the other variables in patients (a) where the Euroscore was obtained and (b) without EuroScore. Variables with a p value ≤ 0.05 (likelihood ratio test) were considered as statistically significant. Multivariable models were compared with the likelihood ratio test. All statistical analyses were performed using Stata™ (Stata Statistical Software: Release 13. College Station, TX: StataCorp LP).

Results

Study population

We analysed data from 2972 patients (2105 male, approximately 71%) undergoing cardiac surgery. Of those, 1568 patients underwent CABG, 729 AV, 359 AV + CABG, 262 MV, and 54 MV + TV, respectively. After surgery, patients were transferred to ICU. The median interquartile range (IQR) stay in ICU for all patients was 2 (1–4) days and the median (IQR) of mechanical ventilation was 12 (8–18) hours after surgery. Amongst 2972 patients, 40 (1.3%) died in ICU after surgery. The 30-day mortality was 1.6% (49 patients), the 90-day mortality was 1.9% (56 patients). Spearmen correlation did not show a significant correlation between age and IL-6 levels 6 h after surgery (r = 0.005; p = 0.776). For details, see Table 1.

Table 1 Characteristics of the study population

Possible predictors for mortality in ICU after cardiac surgery

We investigated the association of the EuroScore and IL-6 serum levels with other possible predictors for mortality in ICU after cardiac surgery. In the univariable models, a higher EuroScore and higher IL-6 levels were associated with mortality in ICU after surgery. For IL-6, only the highest quintile (> 421 pg/ml) reached the significance level. In addition, older age, elevated pre-operative serum creatinine, longer CPB time and lower EF, as well as kind of surgery (with a lower risk for CABG and AV and the highest risk after MV and TV replacement) were associated with mortality in ICU after surgery. The results are summarized in more detail in Table 2.

Table 2 Investigation of possible predictors for mortality after cardiac surgery

Possible predictors for prolonged mechanical ventilation and length of stay in ICU after cardiac surgery

In an additional analysis, we investigated the known risk factors from the primary analysis (above) and chose as outcome parameters (a) duration of ventilation (in hours, dividing the patients into two sub-groups, less or more than 12 h) and (b) duration of treatment in ICU (in days, again dividing the patients into 2 sub-groups, less or more than 2 days). In univariable analyses, we could confirm that both outcome parameters, the EuroScore and IL-6 serum levels as well as the other predictors for mortality in ICU after surgery (Table 2) were associated with the duration of ventilation and the length of stay in ICU (Tables 3, 4, respectively). IL-6 measures did not reach significance level in the univariable model for duration of stay in ICU, however, confidence intervals showed a difference for the sub-group with highest IL-6 levels. To identify possible confounding factors, we then included all selected parameters in a multivariable model. Results of all selected parameters except sex were consistent with the univariable analyses, thus suggesting that all these parameters are associated with duration of ventilation and length of stay in ICU. The type of surgery was not associated with the time of ventilation in this setting. Taking a closer look at IL-6 measures, association strengthened further in the multivariable analyses, with strong association observed not only in the highest quintile of IL-6 levels, but already in the lower quantiles (Tables 3, 4, respectively). We observed that the duration of mechanical ventilation and length of stay increased in patients with a combination of higher EuroScore and higher IL-6 measures, than elevated EuroScore and IL-6 measures alone (regression model including interaction terms, likelihood ratio test: p = 0.01 and p = 0.003, respectively, details are provided in Additional file 1: Table S1 and Additional file 2: Table S2). As the EuroScore could not be obtained in 125 patients, we performed sensitivity analyses for the other variables in patients (a) with EuroScore and (b) without EuroScore. After adjustment for confounders, results remained robust in all analyses, indicating that the EuroScore and IL-6 measures alone and combined, were excellent predictors for all investigated outcomes.

Table 3 Investigation of possible predictors for duration of ventilation after cardiac surgery
Table 4 Investigation of possible predictors for duration of stay in ICU after surgery

Discussion

Prediction of morbidity and mortality after cardiac surgery during the stay in ICU is a very important issue for the patients, for the management of an ICU, and for the relatives of the patients. Furthermore, predictors should also be able to guide clinicians in making recommendations about an operation by helping them to weigh the risks against the benefits. These predictors may also serve as an instrument of quality control. In our study, the EuroScore as well as IL-6 measures were associated with an increased mortality after cardiac surgery. Furthermore, a higher EuroScore (calculated before operation) and significant elevated IL-6 levels (measured 6 h after operation) were predictors for prolonged mechanical ventilation and a longer stay in ICU.

In his work, Meadows et al. [11] showed the predictive value of the EuroScore in terms of length of stay in ICU. Since this evaluation has been performed in a single centre in the UK, these findings cannot be generally applied to patients outside the UK without further investigation. However, observations made by Meadows et al. [11] are consistent with the findings in our trial conducted with a large sample size of 2972 patients residing in Germany. While Meadows et al. [11] analysed the value of the EuroScore in predicting the length of stay in ICU after cardiac surgery, our analyses could also show the potential of the EuroScore in predicting the length of mechanical ventilation. This is a very important finding especially when there are limited resources for mechanical ventilation. During the COVID-19 pandemic, when many hospitals faced a severe shortage of resources for the mechanical ventilation [15], an instrument that helps to manage the usage of respirators is extremely valuable.

Another interesting and surprising finding of our analyses was that the variable, gender (female) is associated with an increased mortality without being associated with prolonged mechanical ventilation. The findings in our study support a well-known phenomenon in cardiac surgery, namely that women have higher morbidity and mortality after cardiac surgery than men. Different explanations for this phenomenon have been suggested. This includes anatomically smaller coronary arteries in the female heart, the older age of women undergoing cardiac surgery, a higher likelihood of unstable angina and higher rates of comorbidities in women [16, 17]. In general, scientific data supporting these explanations are still rare. One possible approach is seen in a higher risk for new neurological events after cardiac surgery as a cause for increased 30-day mortality in women undergoing cardiac surgery [18]. The scientific discussion related to the influence of female gender on prolonged mechanical ventilation after surgery is controversial [19]. Some work favours female gender as a risk factor in these circumstances, other suggest no influence of the female gender on prolonged mechanical ventilation [19]. In our study, female gender was not a predictor for the length of mechanical ventilation. To address this question in more detail, further research has to be performed with this specific scientific question.

Several risk models have been developed to predict mortality after cardiac surgery [20]. One of the best-known risk models for patients undergoing cardiac surgery is the EuroScore [9]. The EuroScore was initially developed to predict the peri-operative mortality in patients undergoing CABG [9]. It is known that different versions of the EuroScore exist, an additive and a logistic version. The additive version is easier and more practical to use than the logistic form [21]. There is still an ongoing controversy concerning the possible advantages of one model over the other [21]. Depending on the analysed patient group and the scientific issue, researchers found no advantage of using the logistic over the additive model [22], others found advantages of the logistic model in high-risk patients [23]. However, the additive EuroScore has been validated as predictor for the postoperative course after cardiac surgery [11, 24,25,26]. Since it is more convenient to use, the additive EuroScore, we used this version in our study. We could show that the additive EuroScore is also a good predictor for the length of stay in ICU and for the duration of mechanical ventilation.

Off-pump cardiac procedures are associated with decrease in inflammatory response and postoperative morbidity, however, CPB is still inevitable in a large number of surgical procedures [27, 28]. Notwithstanding the tireless development and improvement of CPB, CPB still leads to activation of the coagulation, fibrinolytic, and inflammatory system [29,30,31]. These pathophysiological changes are most reasonably caused by the exposition of the blood to the artificial surface of the bypass circuit [32]. The consequence is frequently a degranulation of leukocytes and a release of cytotoxic and inflammatory mediators such as interleukins [29,30,31]. Lymphocytes, fibroblasts, macrophages, and endothelial cells are the main source for secretion of IL-6 in humans [33]. IL-6 itself is an important proinflammatory mediator well characterized in the orchestration of the inflammatory processes [34]. It has been suggested that the myocardium produces IL-6 during phases of compromised myocardial function as a result of ischemia and reperfusion injuries [35]. Furthermore, the surgical trauma might also be reasonable for an increase of IL-6 within the first 4 to 6 h after surgery [35, 36]. These close interlockings of IL-6, surgical trauma and myocardial function makes IL-6 an interesting parameter for predicting the outcome of cardiac surgery in ICU. Indeed, our analyses showed that especially IL-6 serum levels 6 h after operation could be a useful predictor for mortality, prolonged mechanical ventilation, and prolonged stay in ICU after cardiac surgery. IL-6 measures therefore might be a helpful parameter to optimize the management of postoperative processes and planning in ICU. Interestingly, the combination of IL-6 and EuroScore might even improve the prediction of death, prolonged mechanical ventilation, and prolonged stay in ICU after cardiac surgery. Therefore, one should consider including the inflammatory response after operations (e.g., IL-6 6 h after operations) when revising the EuroScore.

Strength and limitations

Strength of our study is the large dataset of patients and the large number of various patient-related variables that could be included. Furthermore, we could show for the first time the important role of IL-6 in predicting the outcome during intensive care treatment.

The retrospective study design might be a limitation. Even if our patients are treated by standard operating procedures, we cannot rule out that some results have been influenced by modified treatment due to peri-operative complications. Furthermore, the study refers to a single centre regional database, thus our results need to be further evaluated in other institutions and countries. It has been shown that both additive and logistic EuroScore were predictive for the outcome after cardiac surgery [37]. For our study, we used the additive EuroScore since it is very easy to use in clinical practice. Thus, we cannot rule out that the use of the logistic EuroScore may lead to different results. A significant correlation of NT-BNP and the EuroScore has been shown in the past [38]. To minimize any interferences in our statistical model, we decided not to include this parameter in our analyses. It might be possible that analysing cardiac-related biomarkers as NT-BNP or troponin might be also useful to predict the course in ICU. Finally, we focused on the evaluation of IL-6 as an inflammatory marker, therefore we cannot rule out that analysing other inflammatory markers (e.g., C-reactive protein, procalcitonin or white blood cell count) may lead to different results.

Conclusion and outlook

Especially in the context of the COVID-19-pandemia but already before, allocation of ICU capacities and efficient resource allocation are important topics not just limited to cardiac surgery. Therefore, both pre-operative risk evaluation and postoperative outcome estimation are important aspects not only in the background of catastrophic situations, but also in regular major surgery settings. The results of our study support the eligibility of an existing Score (EuroScore) and the utilization of an easy to measure parameter (IL-6) for prediction of the course of cardiac surgery thus supporting the clinical aspects and resource discussions. In the context of newly developed scoring systems for this specific purpose, our data should be considered in the future advancements of these scoring systems to support clinical decision-making, allocation of resources and improvement of care for high-risk patients before and during intensive care treatment.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request (in compliance with data privacy).

References

  1. 1.

    Weisse AB. Cardiac surgery: a century of progress. Tex Heart Inst J. 2011;38:486–90.

    PubMed  PubMed Central  Google Scholar 

  2. 2.

    Ranucci M, Baryshnikova E, Crapelli GB, Rahe-Meyer N, Menicanti L, Frigiola A, et al. Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery. J Am Heart Assoc. 2015;4:e002066.

    Article  Google Scholar 

  3. 3.

    Mazzeffi M, Zivot J, Buchman T, Halkos M. In-hospital mortality after cardiac surgery: patient characteristics, timing, and association with postoperative length of intensive care unit and hospital stay. Ann Thorac Surg. 2014;97:1220–5.

    Article  Google Scholar 

  4. 4.

    Siregar S, Groenwold RH, de Mol BA, Takkenberg JJ, Bots ML, van der Graaf Y, et al. Evaluation of cardiac surgery mortality rates: 30-day mortality or longer follow-up? Eur J Cardiothorac Surg. 2013;44:875–83.

    Article  Google Scholar 

  5. 5.

    Pitkanen O, Niskanen M, Rehnberg S, Hippelainen M, Hynynen M. Intra-institutional prediction of outcome after cardiac surgery: comparison between a locally derived model and the EuroSCORE. Eur J Cardiothorac Surg. 2000;18:703–10.

    CAS  Article  Google Scholar 

  6. 6.

    O’Connor GT, Plume SK, Olmstead EM, Coffin LH, Morton JR, Maloney CT, et al. Multivariate prediction of in-hospital mortality associated with coronary artery bypass graft surgery Northern New England Cardiovascular Disease Study Group. Circulation. 1992;85(6):2110–8.

    Article  Google Scholar 

  7. 7.

    Bridgewater B, Neve H, Moat N, Hooper T, Jones M. Predicting operative risk for coronary artery surgery in the United Kingdom: a comparison of various risk prediction algorithms. Heart. 1998;79:350–5.

    CAS  Article  Google Scholar 

  8. 8.

    Tu JV, Jaglal SB, Naylor CD. Multicenter validation of a risk index for mortality, intensive care unit stay, and overall hospital length of stay after cardiac surgery Steering Committee of the Provincial Adult Cardiac Care Network of Ontario. Circulation. 1995;91:677–84.

    CAS  Article  Google Scholar 

  9. 9.

    Nashef SA, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999;16:9–13.

    CAS  Article  Google Scholar 

  10. 10.

    Roques F, Nashef SA, Michel P, Gauducheau E, de Vincentiis C, Baudet E, et al. Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients. Eur J Cardiothorac Surg. 1999;15:816–22 (discussion 22-3).

    CAS  Article  Google Scholar 

  11. 11.

    Meadows K, Gibbens R, Gerrard C, Vuylsteke A. Prediction of patient length of stay on the intensive care unit following cardiac surgery: a logistic regression analysis based on the cardiac operative mortality risk calculator EuroSCORE. J Cardiothorac Vasc Anesth. 2018;32:2676–82.

    Article  Google Scholar 

  12. 12.

    Lindman BR, Goldstein JS, Nassif ME, Zajarias A, Novak E, Tibrewala A, et al. Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement. Heart. 2015;101:537–45.

    CAS  Article  Google Scholar 

  13. 13.

    Zakkar M, Ascione R, James AF, Angelini GD, Suleiman MS. Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery. Pharmacol Ther. 2015;154:13–20.

    CAS  Article  Google Scholar 

  14. 14.

    Franke A, Lante W, Fackeldey V, Becker HP, Kurig E, Zöller LG, et al. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know? Eur J Cardiothorac Surg. 2005;28:569–75.

    Article  Google Scholar 

  15. 15.

    Plummer AR, du Bois JL, Flynn JM, Roesner J, Lee SM, Magee P, et al. A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model. PLoS ONE. 2020;15:e0242123.

    CAS  Article  Google Scholar 

  16. 16.

    Khan SS, Nessim S, Gray R, Czer SL, Chaux A, Matloff J. Increased mortality of women in coronary artery bypass surgery: evidence for referral bias. Ann Intern Med. 1990;112:561–7.

    CAS  Article  Google Scholar 

  17. 17.

    Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RW. Impact of gender on coronary by pass operative mortality. Ann Thorac Surg. 1998;66:125–31.

    CAS  Article  Google Scholar 

  18. 18.

    Hogue CW Jr, Barzilai B, Pieper KS, Coombs LP, DeLong ER, Kouchoukos NT, et al. Sex differences in neurological outcomes and mortality after cardiac surgery: a society of thoracic surgery national database report. Circulation. 2001;103(2133):7.

    Google Scholar 

  19. 19.

    Totonchi Z, Baazm F, Chitsazan M, Seifi S, Chitsazan M. Predictors of prolonged mechanical ventilation after open heart surgery. J Cardiovasc Thorac Res. 2014;6:211–6.

    Article  Google Scholar 

  20. 20.

    Messaoudi N, De Cocker J, Stockman BA, Bossaert LL, Rodrigus IE. Is EuroSCORE useful in the prediction of extended intensive care unit stay after cardiac surgery? Eur J Cardiothorac Surg. 2009;36:35–9.

    Article  Google Scholar 

  21. 21.

    Michel P, Roques F, Nashef SA, Euro SPG. Logistic or additive EuroSCORE for high-risk patients? Eur J Cardiothorac Surg. 2003;23:684–7 (discussion 7).

    Article  Google Scholar 

  22. 22.

    Mestres CA, Castro MA, Bernabeu E, Josa M, Cartaná R, Pomar JL, et al. Preoperative risk stratification in infective endocarditis. Does the EuroSCORE model work? Preliminary results. Eur J CardiothoracSurg. 2007;32:281–5.

    Article  Google Scholar 

  23. 23.

    Zingone B, Pappalardo A, Dreas L. Logistic versus additive EuroSCORE. A comparative assessment of the two models in an independent population sample. Eur J Cardiothorac Surg. 2004;26:1134–40.

    Article  Google Scholar 

  24. 24.

    Pinna Pintor P, Bobbio M, Colangelo S, Veglia F, Marras R, Diena M. Can EuroSCORE predict direct costs of cardiac surgery? Eur J Cardiothorac Surg. 2003;23:595–8.

    Article  Google Scholar 

  25. 25.

    Gurler S, Gebhard A, Godehardt E, Boeken U, Feindt P, Gams E. EuroSCORE as a predictor for complications and outcome. Thorac Cardiovasc Surg. 2003;51:73–7.

    CAS  Article  Google Scholar 

  26. 26.

    Kurki TS, Jarvinen O, Kataja MJ, Laurikka J, Tarkka M. Performance of three preoperative risk indices; CABDEAL, EuroSCORE and Cleveland models in a prospective coronary bypass database. Eur J Cardiothorac Surg. 2002;21:406–10.

    Article  Google Scholar 

  27. 27.

    Ercan A, Karal IH, Gurbuz O, Kumtepe G, Onder T, Saba D. A comparison of off-pump and on-pump coronary bypass surgery in patients with low EuroSCORE. J Cardiothorac Surg. 2014;9:105.

    Article  Google Scholar 

  28. 28.

    Hazama S, Eishi K, Yamachika S, Noguchi M, Ariyoshi T, Takai H, et al. Inflammatory response after coronary revascularization: off-pump versus on-pump (heparin-coated circuits and poly2methoxyethylacrylate-coated circuits). Ann Thorac Cardiovasc Surg. 2004;10:90–6.

    PubMed  Google Scholar 

  29. 29.

    Holcomb HB, Stammers AH, Gao C, Nutter B, Ellis T, Ahlgren RL, et al. Perfusion treatment algorithm: methods of improving the quality of perfusion. J Extra Corpor Technol. 2003;35:290–6.

    PubMed  Google Scholar 

  30. 30.

    Allan CK, Newburger JW, McGrath E, Elder J, Psoinos C, Laussen PC, et al. The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass. Anesth Analg. 2010;111:1244–51.

    Article  Google Scholar 

  31. 31.

    Heyn J, Beiras-Fernandez A, Luchting B, Briegel J, Weis F. Inflammatory reactions and hydrocortisone in the setting of cardiac surgery: an overview. Cardiovasc Hematol Agents Med Chem. 2011;9:56–61.

    CAS  Article  Google Scholar 

  32. 32.

    Day JR, Taylor KM. The systemic inflammatory response syndrome and cardiopulmonary bypass. Int J Surg. 2005;3:129–40.

    CAS  Article  Google Scholar 

  33. 33.

    Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;19:1106–15.

    CAS  Article  Google Scholar 

  34. 34.

    Jones SA, Fraser DJ, Fielding CA, Jones GW. Interleukin-6 in renal disease and therapy. Nephrol Dial Transplant. 2015;30:564–74.

    CAS  Article  Google Scholar 

  35. 35.

    Kanda T, Takahashi T. Interleukin-6 and cardiovascular diseases. Jpn Heart J. 2004;45:183–93.

    CAS  Article  Google Scholar 

  36. 36.

    Kavsak PA, Ko DT, Newman AM, Palomaki GE, Lustig V, MacRae AR, et al. Risk stratification for heart failure and death in an acute coronary syndrome population using inflammatory cytokines and N-terminal pro-brain natriuretic peptide. Clin Chem. 2007;53:2112–8.

    CAS  Article  Google Scholar 

  37. 37.

    Biancari F, Kangasniemi OP, Luukkonen J, Vuorisalo S, Satta J, Pokela R, et al. EuroSCORE predicts immediate and late outcome after coronary artery bypass surgery. Ann Thorac Surg. 2006;82:57–61.

    Article  Google Scholar 

  38. 38.

    Elíasdóttir SB, Klemenzson G, Torfason B, Valsson F. Brain natriuretic peptide is a good predictor for outcome in cardiac surgery. Acta Anaesthesiol Scand. 2008;52(2):182–7.

    Article  Google Scholar 

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Acknowledgements

The authors are grateful to the medical staff of the ICU (HCI) for the excellent support and assistance during the data collection.

Funding

Open Access funding enabled and organized by Projekt DEAL. The study was supported by the institutional funds of the Department of Anaesthesiology, LMU Munich, Germany.

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Authors

Contributions

AB, GJ, EK, and JH designed the study. AB, GJ, IK, and EK collected the data. IK performed the statistical analyses. All authors were involved in the interpretation of the data. AB, IK, EK, and JH wrote the manuscript. GJ and IK were involved in drafting the manuscript and revising it critically for important intellectual content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jens Heyn.

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Ethics approval and consent to participate

The retrospective study protocol followed the principles of the Declaration of Helsinki and was approved by the Institutional Review Board of the Ludwig Maximilians University Munich (approval number: 748-15).

Consent for publication

Not applicable.

Competing interests

JH is also an employee of Sandoz/Hexal, which neither affected the conception and conduction of the study nor the content of this manuscript.

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Supplementary Information

Additional file 1: Table S1.

Multilevel logistic regression models investigating possible predictors for duration of ventilation after cardiac surgery, including testing for interactions for EuroScore and IL-6 levels.

Additional file 2: Table S2.

Multilevel logistic regression models investigating possible predictors for duration of stay in ICU after cardiac surgery, including testing for interactions for Euroscore and IL-6 levels. Baseline are patients being dismissed from ICU ≤ 2 days (compared to patients with being hospitalized on ICU > 2 days).

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Bauer, A., Korten, I., Juchem, G. et al. EuroScore and IL-6 predict the course in ICU after cardiac surgery. Eur J Med Res 26, 29 (2021). https://doi.org/10.1186/s40001-021-00501-1

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Keywords

  • Cardiac surgery
  • Intensive care medicine
  • IL-6
  • EuroScore
  • Outcome
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