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  1. Similar to all antiretroviral drugs, failure of raltegravirbased treatment regimens to fully supress HIV replication almost invariably results in emergence of HIV resistance to this new drug. HIV resistance to...

    Authors: François Clavel
    Citation: European Journal of Medical Research 2009 14(Suppl 3):47

    This article is part of a Supplement: Volume 14 Supplement 3

  2. End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined. However w...

    Authors: Martin Vogel and Mark Nelson
    Citation: European Journal of Medical Research 2009 14(Suppl 3):36

    This article is part of a Supplement: Volume 14 Supplement 3

  3. Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug re...

    Authors: F Cossarini, A Castagna and A Lazzarin
    Citation: European Journal of Medical Research 2009 14(Suppl 3):22

    This article is part of a Supplement: Volume 14 Supplement 3

  4. The analysis of cost effectiveness in hospitals is as difficult as treating the patients properly. We are yet not able to answer the simple question of what costs are caused by a certain diagnosis and its trea...

    Authors: IM Heer, S Kahlert, S Rummel, C Kümper, W Jonat and A Strauss
    Citation: European Journal of Medical Research 2009 14:502
  5. A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival ...

    Authors: T Hattori, K Nakano, T Kawakami, A Tamura, T Ara and PL Wang
    Citation: European Journal of Medical Research 2009 14:497
  6. Current criteria for performing relaparotomy for suspected peritonitis are non explicit and based on non-quantitative, subjective arguments or hospital practice. The aim of this study was to determine the valu...

    Authors: FG Bader, M Schröder, P Kujath, E Muhl, H-P Bruch and C Eckmann
    Citation: European Journal of Medical Research 2009 14:491
  7. Despite having an organ confined tumor stage at the time of radical cystectomy, a certain number of bladder cancer patients will develop local or distant metastases over time. Currently there are no reliable s...

    Authors: A Karl, S Tritschler, S Hofmann, CG Stief and C Schindlbeck
    Citation: European Journal of Medical Research 2009 14:487
  8. Today, the biomechanical fundamentals of skin expansion are based on viscoelastic models of the skin. Although many studies have been conducted in vitro, analyses performed in vivo are rare. Here, we present i...

    Authors: C Marquardt, E Bölke, PA Gerber, G Kukova, M Peiper, E Rusnak, K Orth and W Fleischmann
    Citation: European Journal of Medical Research 2009 14:480
  9. German-Austrian recommendations for HIV1-therapy in pregnancy - Update 2008 Bernd Buchholz (University Medical Centre Mannheim, Pediatric Clinic), Matthias Beichert (Mannheim, Gynecology and Obstetrics Practic...

    Authors: Bernd Buchholz, Matthias Beichert, Ulrich Marcus, Thomas Grubert, Andrea Gingelmaier, Annette Haberl and Brigitte Schmied
    Citation: European Journal of Medical Research 2009 14:461
  10. Training models are required to impart surgical skills, like wound closure techniques, prior to practice in patients. In an ideal case, the tissue characteristics of the model are close to those of humans, eas...

    Authors: PN Khalil, M Siebeck, W Mutschler and K-G Kanz
    Citation: European Journal of Medical Research 2009 14:459
  11. Abnormal hypermethylation of CpG islands associated with tumor suppressor genes can lead to transcriptional silencing in neoplasia. The aim of this study was to investigate the promoter methylation and express...

    Authors: W Guo, Z Dong, Y Guo, G Kuang, Z Yang and Z Chen
    Citation: European Journal of Medical Research 2009 14:453
  12. High tibial osteotomy (HTO) is one treatment option for young and active patients with unicompartmental osteoarthritis. The success of this procedure substantially depends on the degree of correction of the me...

    Authors: J Lützner, AF Groß, KP Günther and S Kirschner
    Citation: European Journal of Medical Research 2009 14:447
  13. Thoracic outlet syndrome (TOS) is a clinical phenomenon resulting from compression of the neurovascular structures at the superior aperture of the thorax which presents with varying symptoms. Regarding to the ...

    Authors: M Sadeghi-Azandaryani, D Bürklein, A Ozimek, C Geiger, N Mendl, B Steckmeier and J Heyn
    Citation: European Journal of Medical Research 2009 14:443
  14. The diagnostic tools to predict the prognosis in patients suffering from breast cancer (BC) need further improvements. New technological achievements like the gene profiling of circulating tumour cells (CTC) c...

    Authors: E Bölke, K Orth, PA Gerber, G Lammering, R Mota, M Peiper, C Matuschek, W Budach, E Rusnak, S Shaikh, B Dogan, HB Prisack and H Bojar
    Citation: European Journal of Medical Research 2009 14:426
  15. As its central basis for research, the Competence Network for HIV/AIDS (KompNet) established a nationwide cohort study on HIV-positive patients being in medical care in Germany. In this paper, we describe the ...

    Authors: K Jansen, NH Brockmeyer, M Hahn, I Kaul, S Fenske, M Rausch, B Kuhlmann, A Ulmer, E Lauenroth-Mai, T Harrer, M Hower, A Skaletz-Rorowski and C Michalik
    Citation: European Journal of Medical Research 2009 14:415
  16. Breast cancer (BC) represents one of the leading causes of cancer related deaths worldwide. New tools for diagnostic staging and therapeutic monitoring are needed to improve individualized therapies and improv...

    Authors: E Bölke, K Orth, PA Gerber, G Lammering, R Mota, M Peiper, C Matuschek, W Budach, E Rusnak, S Shaikh, B Dogan, HB Prisack and H Bojar
    Citation: European Journal of Medical Research 2009 14:359
  17. The Gasperini syndrome is a very rare brainstem disease characterized by the typical combination of ipsilateral lesions of the cranial nerves V-VII and dissociated contralateral hemihypesthesia, whereas both c...

    Authors: M Krasnianski, T Müller, S Zierz and M Winterholler
    Citation: European Journal of Medical Research 2009 14:413
  18. The aim of the present study was to determine whether regular exercise training (ET) is effective at promoting the mobilization of CPCs and improving their functional activity in patients with recently acquire...

    Authors: M Brehm, F Picard, P Ebner, G Turan, E Bölke, M Köstering, P Schüller, T Fleissner, D Ilousis, K Augusta, M Peiper, Ch Schannwell and BE Strauer
    Citation: European Journal of Medical Research 2009 14:393
  19. In IRCU it is uncertain whether variation of urinary protein, especially non-albumin protein (NAlb-P), is due to the presence of stones or reflects alteration of oxidative metabolism.

    Authors: PO Schwille, A Schmiedl and J Wipplinger
    Citation: European Journal of Medical Research 2009 14:378
  20. Quantitative tests of liver function (QTLF) which are based on the hepatic metabolism or clearance of test substances have been successfully used to predict prognosis of a variety of different liver diseases. ...

    Authors: M Miller, A Kahraman, B Ross, M Beste and G Gerken
    Citation: European Journal of Medical Research 2009 14:369
  21. There is a high comorbidity of schizophrenia and obsessive-compulsory disorder (OCD) associated with more severe symptoms. Standard pharmacotherapy achieve symptom improvement in approximately 60% only.

    Authors: F Hanisch, J Friedemann, J Piro and P Gutmann
    Citation: European Journal of Medical Research 2009 14:367
  22. The preferred immunosuppressive drug for long term treatment of myasthenia gravis (MG) is azathioprine (AZA). Mycophenolate mofetil (MMF) was suggested as an effective and safe second line alternative to AZA.

    Authors: F Hanisch, M Wendt and S Zierz
    Citation: European Journal of Medical Research 2009 14:364
  23. We conducted a single-centre, randomised, double-blinded, placebo-controlled phase II clinical study to test safety and efficacy of a 12-week therapy with low-dose (700 mg/daily) or high-dose (2800 mg/daily) o...

    Authors: N Dauletbaev, P Fischer, B Aulbach, J Gross, W Kusche, U Thyroff-Friesinger, TOF Wagner and J Bargon
    Citation: European Journal of Medical Research 2009 14:352
  24. Only 50% of gallbladder cancers (GBC) are recognized before operation and the remaining tumors are diagnosed during surgery or afterwards by the pathologist. These situations may demand substantial modificatio...

    Authors: F Löhe, G Meimarakis, C Schauer, M Angele, KW Jauch and RJ Schauer
    Citation: European Journal of Medical Research 2009 14:345
  25. In this paper, we describe the main objectives, the study design and the onset of the patient cohort of the German Competence Network for HIV/AIDS (KompNet). Furthermore, we depict sociodemographic and clinica...

    Authors: K Jansen, C Michalik, M Hahn, S Dupke, S Esser, H Jaeger, S Köppe, A Moll, A Plettenberg, RE Schmidt, A Skaletz-Rorowski and NH Brockmeyer
    Citation: European Journal of Medical Research 2009 14:323
  26. Rectal polypectomy causes thinning (or even perforation) of the rectal wall in addition to thermic injury at the polypectomy site.

    Authors: WY Khoder, AJ Becker, B Schlenker, S Tritschler, PJ Bastian and CG Stief
    Citation: European Journal of Medical Research 2009 14:320
  27. Macrolide antibiotics are reported to modulate the production of cytokines in various type of cells. We examined the effect of macrolide antibiotics on inflammatory cytokines (IL-6 and IL-8) and chemical media...

    Authors: A Kamemoto, T Ara, T Hattori, Y Fujinami, Y Imamura and P-L Wang
    Citation: European Journal of Medical Research 2009 14:309
  28. High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The primary objective was to evaluate the efficacy of metoprolol X...

    Authors: A Pareek, SD Zawar, SB Salagre, NB Chandurkar and ND Karnik
    Citation: European Journal of Medical Research 2009 14:297
  29. Blood loss during radical prostatectomy has been a long term issue. The aim of this study was to investigate the influence of the training level of the first assistant regarding blood loss in open retropubic r...

    Authors: A Karl, A Buchner, H Beckerv, M Staehler, M Seitz and C Stief
    Citation: European Journal of Medical Research 2009 14:292
  30. Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure...

    Authors: V Bogner, L Keil, K-G Kanz, C Kirchhoff, BA Leidel, W Mutschler and P Biberthaler
    Citation: European Journal of Medical Research 2009 14:284
  31. Dysplasia epiphysealis hemimelica (DEH) or Trevor's Disease is a very rare disease with an estimated incidence of one in 1.000.000. The majority of cases reported affect the lower limb and only 25 case reports...

    Authors: T Vogel, T Skuban, C Kirchhoff, A Baur-Melnyk, S Siegert and B Heimkes
    Citation: European Journal of Medical Research 2009 14:272
  32. Currently, total hip replacement (THR) is most commonly performed via a posterior or a direct lateral approach, but the impact of the latter on the invention's outcome has yet not been quantified.

    Authors: W-C Witzleb, L Stephan, F Krummenauer, A Neuke and K-P Günther
    Citation: European Journal of Medical Research 2009 14:256
  33. The search for influencing factors and new pathways in aseptic loosening of arthroplasties is a major focus of recent studies. Analyses of polymorphisms of genes revealed a correlation between a specific allel...

    Authors: C Wedemeyer, MD Kauther, S Hanenkamp, H Nückel, M Bau, W Siffert and HS Bachmann
    Citation: European Journal of Medical Research 2009 14:250
  34. There is only little data on immune reconstitution in antiretroviral naïve AIDS-patients with toxoplasmosis. The observation of several cases with reduced increase of CD4-cells upon start of antiretroviral tre...

    Authors: U Kastenbauer, E Wolf, C Kollan, O Hamouda and JR Bogner
    Citation: European Journal of Medical Research 2009 14:244
  35. Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses. Despite their benign histologic appearance and lack of me...

    Authors: E Bölke, H Krasniqi, G Lammering, R Engers, C Matuschek, S Gripp, PA Gerber, G Fischer, M Peiper, S Shaikh, W Budach and K Orth
    Citation: European Journal of Medical Research 2009 14:240
  36. Pneumatosis intestinalis has been increasingly detected in recent years with the more frequent use of computed tomography for abdominal imaging of the intestine. The underlying causes of the gas found during r...

    Authors: PN Khalil, S Huber-Wagner, R Ladurner, A Kleespies, M Siebeck, W Mutschler, K Hallfeldt and K-G Kanz
    Citation: European Journal of Medical Research 2009 14:231
  37. Poor adherence to complex multimodal therapies is a widely recognized problem in the daily care of dialysis patients, contributing to excess morbidity and mortality of this population. While a few studies have...

    Authors: H Schmid, B Hartmann and H Schiffl
    Citation: European Journal of Medical Research 2009 14:185
  38. Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association wit...

    Authors: H-J Gdynia, P Weydt, A Ernst, S Klein, A-D Sperfeld and A Riecker
    Citation: European Journal of Medical Research 2009 14:228
  39. Several epidemiological studies address psychosomatic 'self regulation' as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and rec...

    Authors: A Büssing, M Girke, C Heckmann, F Schad, T Ostermann and M Kröz
    Citation: European Journal of Medical Research 2009 14:223
  40. To assess the efficacy and safety of a treatment switch from a twice-daily (BID) regimen containing zidovudine (ZDV) and lamivudine (3TC) plus a third agent to a once daily (QD) regimen containing the fixed-do...

    Authors: K Arasteh, L Weitner, S Fenske, B Kuhlmann, M Freiwald, R Ebrahimi, L Gallo, B Ranneberg and T Mertenskoetter
    Citation: European Journal of Medical Research 2009 14:195
  41. In HIV-infected patients, manifestations of the disease are common in the gastrointestinal tract. The objective of our study was to evaluate the diagnostic yield of the Given® Video Capsule System (Given Imaging,...

    Authors: M Oette, A Stelzer, K Göbels, M Wettstein, A Sagir, T Feldt and D Häussinger
    Citation: European Journal of Medical Research 2009 14:191

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